Protein Alignment EBF3 and SPT23

DIOPT Version :10

• Sequence 1: NP_001362309.1
• Gene: EBF3 / 253738
• HGNCID: 19087
• Length: 629
• Species: Homo sapiens
• Sequence 2: NP_012905.1
• Gene: SPT23 / 853848
• SGDID: S000001503
• Length: 1082
• Species: Saccharomyces cerevisiae
• Alignment Length: 629
• Identity: 129/629 - (20%)
• Similarity: 210/629 - (33%)
• Gaps: 224/629 - (35%)

Human    50 ARAHFEKQPPSN-LRKSNFFHFVLALYDRQGQPVEI--------ERTAFVD-------------- 91
            ||.:|....||: :.|..||       .....|..:        |||.|:|
Yeast   147 ARKNFFIHLPSDCIAKDKFF-------TSSDDPTNLTIPNRDINERTLFLDAFLLCASNNNSNNF 204

Human    92 --------FVEKEKE---------------PNNEKTNNGIHYKLQL--LYSNGVRTEQ-----DL 126
                    .:.:||.               .|||.....|....||  :.:||:....     ||
Yeast   205 KQTYVCNRCINREKRRASRRKSGLNDNSIWQNNENKRAIIFNSKQLFIISNNGLSGNSNCINFDL 269

Human   127 YVRLI------DSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPS------- 178
            ..|::      .:.....:::..:|.|.::....:|..||   ..|||:..| ..||:
Yeast   270 PTRIVCYCRHHKATNGFVVLFLLRDHNGDILAKTITDPIM---IMDKKNASN-TTTPTSTSNAQV 330

Human   179 DPVIID-----------RFFLKFFLKCNQ-------NCL-----KNAGNPRDMRRFQVVVSTTVN 220
            .|:..|           .|..:|.|..|.       ||:     .|..|..|.:......:..:|
Yeast   331 SPMTNDTRSFSSPQSDLNFPSEFPLPSNSKNFVISTNCMLDSNCNNNNNDNDNKNNIKTNTAMMN 395

Human   221 VDGHV-----------LAVSDNMFVHNN-----------------------------------SK 239
            .:.|.           .:.||..|.:||                                   ::
Yeast   396 NNRHFPSPNSSSEDSNHSFSDIHFSNNNDNNLHRSLDSWSSTGFNSSSNPALTTLTSDFSAASAR 460

Human   240 H-GRRARR-------------------LDPSE-----GTAPSYLENATPCIKAISPSEGWTTGGA 279
            | |:|.|.                   :|.|:     .:.|..|.| .|.|:.:.|::|...||.
Yeast   461 HTGKRQRSVNEPFMSTPNTFSRLPQKFIDSSKDISNHNSVPVALNN-KPSIQRVIPAQGSINGGI 524

Human   280 TVIIIGDNFFDGLQVVFGTMLV-----WSE--LITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCK 337
            .|.::|..|..||.:.||..:.     |:|  ::|      ..||...||.|.||:...|:...:
Yeast   525 EVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVT------YLPPSSKPGPVLVTIVDPSETSMR 583

Human   338 GAPGRFVYTA--------LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMP 394
            ......|.|:        ||:.|   |    :|.|..:..|.:|...|:.|:        :.|:.
Yeast   584 NNSNSSVSTSNSTNDILHLNKYT---G----EKAIFTYVDDTDRQLIELALQ--------IVGLK 633

Human   395 HNNQEIILKRAADIAEALY---SVPRN-----HNQIPTLGNNPAHTGMMGVNSFSSQLAVNVSET 451
            .|.:   |:.|.:||:.:.   |.|.|     |:|..:|.   ::|.||. |....||...|.::
Yeast   634 MNGK---LEDARNIAKRIVGSDSSPSNNNAGLHSQNSSLN---SYTNMMR-NINDEQLITEVIKS 691

Human   452 SQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGS 495
            .:.|:.:. :.|.|....||.........:|:.::.:.:..|||
Yeast   692 FKRNNNLS-TVNLSMCDVRGRTLLHLAAFNNWYSLVSLLIKYGS 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EBF3	NP_001362309.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		COE1_DBD	21..247	CDD:435333	60/351 (17%)
		Interaction with DNA. /evidence=ECO:0000250	63..66		1/2 (50%)
		Interaction with DNA. /evidence=ECO:0000250	197..204		3/11 (27%)
		Interaction with DNA. /evidence=ECO:0000250	236..239		2/37 (5%)
		IPT_COE	263..347	CDD:238580	25/90 (28%)
		COE1_HLH	348..391	CDD:406751	10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..483		5/31 (16%)
SPT23	NP_012905.1	IPT	508..578	CDD:238050	23/75 (31%)
		ANKYR	598..>779	CDD:440430	38/160 (24%)
		ANK repeat	709..740	CDD:293786	6/26 (23%)
		ANK repeat	742..767	CDD:293786