Protein Alignment EBF3 and unc-3

DIOPT Version :10

• Sequence 1: NP_001362309.1
• Gene: EBF3 / 253738
• HGNCID: 19087
• Length: 629
• Species: Homo sapiens
• Sequence 2: NP_510453.1
• Gene: unc-3 / 181573
• WormBaseID: WBGene00006743
• Length: 491
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 287/553 - (51%)
• Similarity: 351/553 - (63%)
• Gaps: 105/553 - (18%)

Human    11 GGTTMKEEPLGSGMNPVRSWMH------------TAGVVD-ANTAAQSGVGLARAHFEKQPPSNL 62
            |.....:||    .|||.: :|            |..::| :||:.|    :|||||||.||:||
 Worm    10 GQMNFYDEP----YNPVLN-LHIQPSVKDENQRSTWPIIDTSNTSTQ----IARAHFEKHPPNNL 65

Human    63 RKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLY 127
            |||||||||:|||||..||:|:|||.|..|||||||.:.:.|.|||||:|.|::.||:|:|.||:
 Worm    66 RKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEKEVDGQDTRNGIHYRLSLMFQNGIRSEHDLF 130

Human   128 VRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFL 192
            ||||||.|||||.||||||||||||||||||:||||||:||||||||||||||||||||||||||
 Worm   131 VRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFL 195

Human   193 KCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSY 257
            ||||||||||||||||||||||:.::..:||.:||||||||||||||||||.:|.|.|:.:  .|
 Worm   196 KCNQNCLKNAGNPRDMRRFQVVLCSSARIDGPLLAVSDNMFVHNNSKHGRRTKRTDASDDS--EY 258

Human   258 LENA-----TPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLV-WSE---LITPHAIRV 313
            .|:|     .|.|||:.|||||..||..|::||:|||:||||.|||... |.|   ||:||||||
 Worm   259 SESAELPSSVPVIKALFPSEGWIQGGTQVVLIGENFFEGLQVAFGTASPNWGESVQLISPHAIRV 323

Human   314 QTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEV 378
            .|||:|..|.|:|||.||||.:.:|.|.||.|..|.||.|:||||||||::|::|||||||||:.
 Worm   324 TTPPKHSAGPVDVTLQYKSKTYSRGTPLRFSYITLAEPGIEYGFQRLQKLLPKYPGDPERLPKDQ 388

Human   379 LLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNNPAHTGMMGVNSFSSQ 443
            :|||||:|.||||                            |:..|             .|.||.
 Worm   389 ILKRAAELAEALY----------------------------NRTST-------------ESLSSY 412

Human   444 LAVNVSETSQANDQVGYSRNTSSVSPRGYVP--------SSTPQQSNYNTVSTSMNGYGSGAMAS 500
            .......||.      |:..|.: |||..:|        ||...|::|.||:.:
 Worm   413 YHTQFDATSD------YAARTHT-SPRSTLPYGAGPPALSSAVYQTSYPTVNAT----------- 459

Human   501 LGVPGSPGFLNGSSANSPYGIV-PSSPTMAASS 532
               |.: .|||..:..:.:|.| |.:.|:.:||
 Worm   460 ---PAA-NFLNTQTGFATFGAVNPFAATLQSSS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EBF3	NP_001362309.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		3/10 (30%)
		COE1_DBD	21..247	CDD:435333	165/238 (69%)
		Interaction with DNA. /evidence=ECO:0000250	63..66		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000250	197..204		6/6 (100%)
		Interaction with DNA. /evidence=ECO:0000250	236..239		2/2 (100%)
		IPT_COE	263..347	CDD:238580	52/87 (60%)
		COE1_HLH	348..391	CDD:406751	30/42 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..483		11/39 (28%)
unc-3	NP_510453.1	COE_DBD	45..249	CDD:212156	159/207 (77%)
		IPT_COE	269..357	CDD:238580	52/87 (60%)
		COE1_HLH	358..401	CDD:406751	30/42 (71%)