DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asic2 and ppk26

DIOPT Version :9

Sequence 1:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus
Sequence 2:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	137/581 - (23%)
Similarity:	217/581 - (37%)	Gaps:	186/581 - (32%)

- Green bases have known domain annotations that are detailed below.

  Rat    64 TKLHGLRHMCAGRTAAGGSFQR----RALW----VLAFCTSLGLLLS----WSSNRLLYWLSF-P 115
            |.:||:|::        |..:|    |..|    ||:..|.:.|.|:    |::|.::  :|| .
  Fly    78 TTIHGIRYL--------GEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVI--VSFAE 132

  Rat   116 SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLY-----YAGHWLGLL-----------LPN 164
            ..|.|   |  |:||||||||.....|....:..|.|     :..:..|::           ..:
  Fly   133 KSTPV---W--QIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVS 192

  Rat   165 RTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELC 229
            :...|.:.::..|::.||.  .::.|....:.| ||               :|..|:||:|.
  Fly   193 QVCEPHLHDVTLGNKTRRG--MEIIDALTEVSP-HF---------------DDTYLNCKWRN--- 236

  Rat   230 GPHNFSSVFTKY----GKCYMFNS-----------------------------GEDG-------K 254
            .|...|.:|.|:    |.|:.|||                             .|||       .
  Fly   237 SPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTS 301

  Rat   255 PLLTTVKG-GTGNGLEIML---DIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP-------- 305
            |....|.| |...||.:.:   :|..|:..  |:          .|.|:.:|:..:.
  Fly   302 PYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILLHTPGDVAQVSKQYF 356

  Rat   306 --PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYI 367
              ||.||:...:.|.    :.|....|.:..|...:|. ..|..|.:|.:||.:.|.::|...:.
  Fly   357 RIPFDQEVLISIRPK----IITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFT 417

  Rat   368 VENCNC------RMVHMP--GDAPFCTPEQHKECAEPALGLLAE------------KDSNYCLCR 412
            :..|.|      |.|:||  |||......|    ||..| ||.|            :....|.|.
  Fly   418 LTKCGCVKFSMPRNVNMPVCGDASLKCYNQ----AEDEL-LLREFTQGLVNAGENTRGETECNCL 477

  Rat   413 TPCNLTRYNKELSMVKIPSKT-----SAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKK 472
            ..|....|..|:|......||     |.:..|::..:....:|.    :.|||:...:.|..:.:
  Fly   478 PSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR----VSIFFKEAQFLTSRRSE 538

  Rat   473 AYEVAALLGDIGGQMGLFIGASLLTILELFDYIY----ELI---------KEKLLDLLGKE 520
            .|.....|.:.||.:|||:|.|:|:|:||   ||    .||         :::||..:.|:
  Fly   539 LYGTTDFLANCGGLLGLFMGVSMLSIVEL---IYFCTVRLISNLRMRRKTRKELLKAVNKD 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	137/581 (24%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	131/553 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5010
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.070