DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tshr and rk

DIOPT Version :9

Sequence 1:	NP_037020.2	Gene:	Tshr / 25360	RGDID:	3911	Length:	764	Species:	Rattus norvegicus
Sequence 2:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	251/780 - (32%)
Similarity:	370/780 - (47%)	Gaps:	138/780 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat     4 GSLLQLT----------LLLALPRSLWGRGCTSPPCECHQEDDFRVTCKELHRI--PSLPPSTQT 56
            |:|..||          |:.:||..|         .:..|..:..:|...|..|  ..||.|.|.
  Fly   341 GALKNLTALKVLELDDNLISSLPEGL---------SKLSQLQELSITSNRLRWINDTELPRSMQM 396

  Rat    57 LKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEI--RNTRSLTYIDP 119
            |.:....|.||...||..:..:.::.||...||:     ||..|.....:||  .:...:..:..
  Fly   397 LDMRANPLSTISPGAFRGMSKLRKLILSDVRTLR-----SFPELEACHALEILKLDRAGIQEVPA 456

  Rat   120 DALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKL 184
            :...:.|.||.|.:....|:..|:|:.                             |.:...|.|
  Fly   457 NLCRQTPRLKSLELKTNSLKRIPNLSS-----------------------------CRDLRLLDL 492

  Rat   185 YNNGFTSIQGHAFNGTK-LDAVYLNKNKYLTAIDKDAFGGV--------------------YSGP 228
            .:|....|||..|||.| |:.:.|:.|: :.|:.:|||.|:                    :||.
  Fly   493 SSNQIEKIQGKPFNGLKQLNDLLLSYNR-IKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGF 556

  Rat   229 TLLD---VSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAF---- 286
            |.|:   :.:.....||..||..|..|...|...|::.|...:|..:....|||..|||||
  Fly   557 TALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLV 621

  Rat   287 --KNQKKIRGILESL-----------MCNESSIRNLRQRKSVNVMRG-PVYQEYEEGLGDNHVGY 337
              .:|||...:.|::           :.|.|.:....|..:::...| .::..:|..:..|
  Fly   622 AMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFN---- 682

  Rat   338 KQNSKFQEGP--SNSHYYVFFEEQE----DEIIGFGQEL-KNPQEETLQAFDSHYDYTVCGDNED 395
            ::..:.|.|.  :.|:...:|||.:    ....|||..| .....|..|.             ..
  Fly   683 EEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQP-------------GS 734

  Rat   396 MVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFAD 460
            :.|.|....|.||.|:..:..||..||.|.|::||||..|:||||.|..|:.|||||:||||.||
  Fly   735 VQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAAD 799

  Rat   461 FCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITF 525
            |.||:||.::|.||..|..|:...||.||....|..:||..|.:||||||||.||||||.||||.
  Fly   800 FFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITH 864

  Rat   526 AMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDT-PLALAYIALVLLL 589
            |:.|::::.|:.|..||:.|||...::||:|:||:|.|.|.::|||.:|.| |.:|.|:..::.:
  Fly   865 AIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFI 929

  Rat   590 NVVAFVIVCSCYVKIYITVRNPQ-YNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPL 653
            |..||:.:..||:|:|..:|..| :|  ..|::||||||:|:||||:|.:||:|::::|:....|
  Fly   930 NGCAFLTLMGCYLKMYWAIRGSQAWN--TNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQL 992

  Rat   654 ITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTG 718
            |::..:||..|...|||||.|||||||.||.|::|...      ||||    ::..||......|
  Fly   993 ISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVT------LCKH----FEESRVVGGGGPG 1047

Rat 719 718
Fly 1048 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tshr	NP_037020.2	leucine-rich repeat	54..77	CDD:275380	7/22 (32%)
		LRR_5	65..221	CDD:404228	36/158 (23%)
		leucine-rich repeat	78..102	CDD:275380	7/23 (30%)
		LRR 1	100..124		3/25 (12%)
		leucine-rich repeat	103..127	CDD:275380	2/25 (8%)
		LRR 2	125..150		7/24 (29%)
		leucine-rich repeat	128..177	CDD:275380	6/48 (13%)
		LRR 3	151..174		0/22 (0%)
		LRR 4	176..199		8/22 (36%)
		leucine-rich repeat	180..201	CDD:275380	9/20 (45%)
		LRR 5	201..223		8/22 (36%)
		leucine-rich repeat	202..229	CDD:275380	10/46 (22%)
		LRR 6	225..248		8/25 (32%)
		leucine-rich repeat	230..251	CDD:275380	6/23 (26%)
		LRR 7	264..288		10/29 (34%)
		7tmA_TSH-R	415..689	CDD:320630	136/275 (49%)
		TM helix 1	417..441	CDD:320630	14/23 (61%)
		TM helix 2	450..471	CDD:320630	14/20 (70%)
		TM helix 3	495..517	CDD:320630	13/21 (62%)
		TM helix 4	540..556	CDD:320630	7/15 (47%)
		TM helix 5	580..603	CDD:320630	7/22 (32%)
		TM helix 6	623..645	CDD:320630	14/21 (67%)
		TM helix 7	657..682	CDD:320630	15/24 (63%)
		PDZ-binding	762..764
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	10/50 (20%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	4/17 (24%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	3/6 (50%)
		LRR_RI	327..567	CDD:238064	61/269 (23%)
		leucine-rich repeat	349..371	CDD:275380	4/30 (13%)
		LRR_8	370..425	CDD:290566	15/54 (28%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	17/101 (17%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	18/58 (31%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	8/23 (35%)
		LRR_8	533..589	CDD:290566	11/55 (20%)
		leucine-rich repeat	535..558	CDD:275380	2/22 (9%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	68/127 (54%)
		7tm_1	770..1017	CDD:278431	121/248 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810