DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CADM2 and side-II

DIOPT Version :9

Sequence 1:	XP_016861551.1	Gene:	CADM2 / 253559	HGNCID:	29849	Length:	449	Species:	Homo sapiens
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	66/280 - (23%)
Similarity:	120/280 - (42%)	Gaps:	25/280 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    50 EGGTAILTCR-VDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDE 113
            ||...::||| |.......::|   ....|..|::.......:...|..|.  |:..:|::
  Fly   187 EGDDIVITCRVVGGRPQPQVRW---LVNGLLVDNQNEHNSGDVIENRLLWP--SVQRNDLN---- 242

Human   114 GQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSP---VMEGDLMQLTCKTSGSKPAADIRWFK 175
            ..:||......:...|....:|.:..||.:.....|   ::.....:::|::|||:|.|.|.|:|
  Fly   243 SVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAIITWYK 307

Human   176 NDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYT 240
            ..::::..|    :|.::.  :..|.|.|.....|||.::.||.::.::|......|..|.:.|.
  Fly   308 GKRQLRRTK----DDISKN--STRSELSFVPTTDDDGKSITCRAENPNVNGLYLETMWKLNVVYP 366

Human   241 PSVKI-IPSTPFP---QEGQPLILTCESKGKPLPEPVLWTKDGGELP--DPDRMVVSGRELNILF 299
            |.|.: :.||..|   :||..:...|..:..|....:||..:|..|.  ...|::.|.:.|.:..
  Fly   367 PLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHNTSARVIRSNQSLVLQK 431

Human   300 LNKTDNGTYRCEATNTIGQS 319
            :.|...|.|.|.|.|..|::
  Fly   432 ITKHYAGNYACSAINDEGET 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CADM2	XP_016861551.1	None
side-II	NP_001014485.3	IG_like	55..160	CDD:214653
		Ig	57..160	CDD:299845
		Ig	188..251	CDD:299845	14/71 (20%)
		Ig	289..363	CDD:299845	22/79 (28%)
		IG_like	289..351	CDD:214653	19/67 (28%)
		Ig_2	376..460	CDD:290606	20/76 (26%)
		IG_like	383..454	CDD:214653	18/69 (26%)
		Ig	470..548	CDD:299845
		IG_like	481..557	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11207
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910