DRSC/TRiP Functional Genomics Resources

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Protein Alignment CADM2 and syg-2

DIOPT Version :10

Sequence 1:XP_016861551.1 Gene:CADM2 / 253559 HGNCID:29849 Length:449 Species:Homo sapiens
Sequence 2:NP_001309674.1 Gene:syg-2 / 181561 WormBaseID:WBGene00007750 Length:1230 Species:Caenorhabditis elegans


Alignment Length:482 Identity:99/482 - (20%)
Similarity:180/482 - (37%) Gaps:102/482 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    32 LHQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSL--QWSNPAQQTLYFDDKKAL--RDNRIE 92
            :|..||.......|::.:.|.:....|..:::....:  ||.:.....|.:..:..|  ...|..
 Worm    14 IHISSQFFLESPSNLSTIAGESITFRCSAEKSPEPIVYSQWKSNTGSLLGYHQEGILPGHQGRFS 78

Human    93 LVRASWHELSISVSDVSLSDEGQYTCSLF---TMPVKTSKAYLTVLGVPEKPQISGFSS------ 148
            .::.:..||.:.::.|:|.|:|:|.|.:.   ..|:: :|::|.:: ||  ||:..||:      
 Worm    79 YIKQNAEELHLKITHVNLDDDGEYECQMLHPEEGPIR-AKSFLNII-VP--PQLVYFSNYQPNSI 139

Human   149 -PVMEGDLMQLTCKTSGSKPAADIRWFKNDKEI-KDVKYLKEEDANRKTFTVSSTLDFRVDRSDD 211
             .|.|...:.:||.....||..::.|:.:.|.: :|||.......| |||||.::|..:.||:|.
 Worm   140 IAVKENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVKQASTPHLN-KTFTVYTSLVVQSDRNDH 203

Human   212 GVAVICRV--DHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVL 274
            |..:.|..  ....:..|....:.||.....|:|:|:.:....:.|..:.:.|...|...|..|.
 Worm   204 GKVITCEAFQKETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIACSVTGGNPPPDVF 268

Human   275 WTKDGGELPDPDRMVVSGRELNILF---LNKTDN-GTYRCEATNT-------------------- 315
            |..:...|.....:....:|:..::   .::.|| ..|.|.|.|:                    
 Worm   269 WYHENKRLQSHSTLDTRSKEIKNIYSFIASQNDNMAEYECRANNSRTGNPKRKAMKLEVNYPPAS 333

Human   316 ---IGQSSAEYVLIVHDVPNTLLP-------TTIIPSLTTATVTTTVAITTSPTTSATTSSIRDP 370
               .|:|:..|.... ::....||       |.||...:..|.|....:..:...|::..|:.. 
 Worm   334 VELFGESNIRYGSSA-NIQCKSLPSNPASQITWIINGRSVPTPTQREFVVENGIVSSSNVSVHS- 396

Human   371 NALA----------------GQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAK 419
            |.|:                |.:...|.:                    :.:|..|...:|    
 Worm   397 NELSVEAHQINVECMATNPEGSSAKQHVI--------------------KIIAPPKAPIIT---- 437

Human   420 GAEDAPDADTAIIN----AEGSQVNAE 442
            |.||....:..|:|    |:|....||
 Worm   438 GLEDRKFFEGDIVNVTCEAQGGNPLAE 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CADM2XP_016861551.1 IgV_1_Necl-3 40..135 CDD:409498 19/101 (19%)
Ig strand A 40..43 CDD:409498 0/2 (0%)
FR1 41..59 CDD:409498 2/17 (12%)
Ig strand A' 44..50 CDD:409498 1/5 (20%)
Ig strand B 52..60 CDD:409498 1/7 (14%)
CDR1 60..65 CDD:409498 0/4 (0%)
FR2 66..73 CDD:409498 2/8 (25%)
Ig strand C 66..72 CDD:409498 2/7 (29%)
CDR2 74..85 CDD:409498 1/10 (10%)
Ig strand C' 76..80 CDD:409498 1/3 (33%)
Ig strand C' 82..85 CDD:409498 0/2 (0%)
FR3 86..121 CDD:409498 10/36 (28%)
Ig strand D 90..97 CDD:409498 1/6 (17%)
Ig strand E 100..106 CDD:409498 2/5 (40%)
Ig strand F 113..121 CDD:409498 3/7 (43%)
CDR3 122..125 CDD:409498 0/2 (0%)
Ig strand G 125..135 CDD:409498 2/9 (22%)
FR4 127..134 CDD:409498 2/6 (33%)
IgI_2_Necl-3 134..237 CDD:409467 32/112 (29%)
Ig strand A 135..138 CDD:409467 0/2 (0%)
Ig strand A' 141..145 CDD:409467 2/3 (67%)
Ig strand B 154..164 CDD:409467 2/9 (22%)
Ig strand C 167..176 CDD:409467 2/8 (25%)
Ig strand C' 177..180 CDD:409467 1/2 (50%)
Ig strand D 182..189 CDD:409467 3/6 (50%)
Ig strand E 195..205 CDD:409467 5/9 (56%)
Ig strand F 213..221 CDD:409467 1/9 (11%)
Ig strand G 229..236 CDD:409467 1/6 (17%)
Ig_3 241..314 CDD:464046 16/76 (21%)
4.1m 402..420 CDD:128590 3/17 (18%)
syg-2NP_001309674.1 IG_like 25..105 CDD:214653 15/79 (19%)
Ig strand B 36..40 CDD:409353 0/3 (0%)
Ig strand C 49..55 CDD:409353 1/5 (20%)
Ig strand E 83..91 CDD:409353 2/7 (29%)
Ig strand F 101..105 CDD:409353 1/3 (33%)
Ig 139..228 CDD:472250 24/89 (27%)
Ig strand B 148..152 CDD:409353 0/3 (0%)
Ig strand C 162..166 CDD:409353 0/3 (0%)
Ig strand E 192..196 CDD:409353 1/3 (33%)
Ig strand F 206..211 CDD:409353 1/4 (25%)
Ig strand G 221..224 CDD:409353 1/2 (50%)
Ig_3 235..312 CDD:464046 16/76 (21%)
Ig 430..537 CDD:472250 11/39 (28%)
Ig strand B 450..454 CDD:409353 1/3 (33%)
Ig strand C 464..468 CDD:409353 1/1 (100%)
Ig strand E 501..505 CDD:409353
Ig strand F 515..520 CDD:409353
Ig strand G 530..533 CDD:409353
Ig 540..635 CDD:472250
Ig strand B 562..566 CDD:409353
Ig strand C 576..585 CDD:409353
Ig strand E 610..614 CDD:409353
Ig strand F 624..629 CDD:409353
Ig 657..738 CDD:472250
Ig strand B 668..672 CDD:409353
Ig strand C 682..686 CDD:409353
Ig strand F 718..723 CDD:409353
Ig strand G 731..734 CDD:409353
Ig_3 743..814 CDD:464046
Ig 848..922 CDD:472250
Ig strand B 851..855 CDD:409353
Ig strand C 865..868 CDD:409353
Ig strand E 895..899 CDD:409353
Ig strand F 910..915 CDD:409353
FN3 934..1023 CDD:238020
Blue background indicates that the domain is not in the aligned region.

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