Sequence 1: | NP_001457.1 | Gene: | FZD2 / 2535 | HGNCID: | 4040 | Length: | 565 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
Alignment Length: | 529 | Identity: | 124/529 - (23%) |
---|---|---|---|
Similarity: | 216/529 - (40%) | Gaps: | 120/529 - (22%) |
- Green bases have known domain annotations that are detailed below.
Human 63 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---EQAIPPCRSICERARQGCEA 123
Human 124 LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGA 188
Human 189 PPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMF--------------FSQE 239
Human 240 ETRFARLWILTWS-VLCCASTFFTVTTYLVDMQRF-RYPERPIIFLSGCYTMVSVAYIAGFV--L 300
Human 301 QERVVCNERFSEDGYRTVVQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGH- 362
Human 363 -EAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFI 426
Human 427 GTSFLLAGFVSLFRIRTIMKH------DGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQA 485
Human 486 FREHWERSWVSQH--CKSLAIPCPAHYTPRMS------PDFTVYMIKYLMTLIVGITSGFWIWSG 542
Human 543 KTLHSWRKF 551 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
FZD2 | NP_001457.1 | CRD_FZ2 | 35..161 | CDD:143573 | 22/101 (22%) |
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 160..189 | 5/28 (18%) | |||
7tmF_FZD2 | 234..563 | CDD:320373 | 90/354 (25%) | ||
TM helix 1 | 244..268 | CDD:320373 | 6/24 (25%) | ||
TM helix 2 | 277..298 | CDD:320373 | 2/20 (10%) | ||
TM helix 3 | 328..350 | CDD:320373 | 7/21 (33%) | ||
TM helix 4 | 371..387 | CDD:320373 | 10/15 (67%) | ||
TM helix 5 | 409..432 | CDD:320373 | 7/22 (32%) | ||
TM helix 6 | 463..485 | CDD:320373 | 8/21 (38%) | ||
TM helix 7 | 514..539 | CDD:320373 | 6/30 (20%) | ||
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 543..548 | 0/4 (0%) | |||
PDZ-binding | 563..565 | ||||
smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 31/164 (19%) |
Frizzled | 246..568 | CDD:279827 | 90/339 (27%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |