| Sequence 1: | NP_001457.1 | Gene: | FZD2 / 2535 | HGNCID: | 4040 | Length: | 565 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001300437.1 | Gene: | mom-5 / 172856 | WormBaseID: | WBGene00003397 | Length: | 570 | Species: | Caenorhabditis elegans |
| Alignment Length: | 560 | Identity: | 214/560 - (38%) |
|---|---|---|---|
| Similarity: | 303/560 - (54%) | Gaps: | 71/560 - (12%) |
- Green bases have known domain annotations that are detailed below.
|
Human 36 HGF-----CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSM 95
Human 96 YAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSE--- 157
Human 158 --------DGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVP--SYLS 212
Human 213 YKFLGER--DCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRY 275
Human 276 PERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMA 340
Human 341 SSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVG 405
Human 406 LNSLDP--LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTE----KLERLMVRIGV 464
Human 465 FSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSL--------AIP---CPAHYTPRM-SPD 517
Human 518 FTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTN 557 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD2 | NP_001457.1 | CRD_FZ2 | 35..161 | CDD:143573 | 71/140 (51%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 160..189 | 4/28 (14%) | |||
| 7tmF_FZD2 | 234..563 | CDD:320373 | 129/342 (38%) | ||
| TM helix 1 | 244..268 | CDD:320373 | 9/23 (39%) | ||
| TM helix 2 | 277..298 | CDD:320373 | 8/20 (40%) | ||
| TM helix 3 | 328..350 | CDD:320373 | 9/21 (43%) | ||
| TM helix 4 | 371..387 | CDD:320373 | 8/15 (53%) | ||
| TM helix 5 | 409..432 | CDD:320373 | 8/24 (33%) | ||
| TM helix 6 | 463..485 | CDD:320373 | 6/21 (29%) | ||
| TM helix 7 | 514..539 | CDD:320373 | 9/25 (36%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 543..548 | 3/4 (75%) | |||
| PDZ-binding | 563..565 | ||||
| mom-5 | NP_001300437.1 | CRD_FZ1_like | 35..147 | CDD:143567 | 63/114 (55%) |
| 7tmF_Frizzled_SMO | 219..550 | CDD:320089 | 127/335 (38%) | ||
| TM helix 1 | 228..253 | CDD:320089 | 9/24 (38%) | ||
| TM helix 2 | 262..282 | CDD:320089 | 8/19 (42%) | ||
| TM helix 3 | 312..338 | CDD:320089 | 11/25 (44%) | ||
| TM helix 4 | 355..371 | CDD:320089 | 8/15 (53%) | ||
| TM helix 5 | 393..422 | CDD:320089 | 9/28 (32%) | ||
| TM helix 6 | 446..473 | CDD:320089 | 10/26 (38%) | ||
| TM helix 7 | 512..537 | CDD:320089 | 9/24 (38%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 251 | 1.000 | Domainoid score | I1282 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 401 | 1.000 | Inparanoid score | I1230 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S3599 |
| OMA | 1 | 1.010 | - | - | QHG48699 | |
| OrthoDB | 1 | 1.010 | - | - | D167933at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001848 | |
| OrthoInspector | 1 | 1.000 | - | - | otm15852 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104642 | |
| Panther | 1 | 1.100 | - | - | O | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 14 | 13.790 | |||||