DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ros1 and Sdr

DIOPT Version :9

Sequence 1:	XP_038954373.1	Gene:	Ros1 / 25346	RGDID:	3591	Length:	2339	Species:	Rattus norvegicus
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	76/389 - (19%)
Similarity:	121/389 - (31%)	Gaps:	139/389 - (35%)

- Green bases have known domain annotations that are detailed below.

  Rat  1451 LNATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSS--DRKHN------MLESQENV 1507
            ||:|...:||..      :.|.|:.|... |..:|.||...|.:  |.:|.      :::...|.
  Fly   497 LNSTAVRIILDY------MDWEGMETLIG-YSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQ 554

  Rat  1508 AR---IEGLQPFSTYVIQIAVKNYYSDPLEHLSLGKEIQGKTKSGV-------PGAVCHINATVL 1562
            :|   |.||:|::.|.       |:...|.......:|...:|.|.       |..|..|..:..
  Fly   555 SRRHVISGLKPYTQYA-------YFVKTLTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSE 612

  Rat  1563 SDTSLLVFWTESHKPNG-------------------PKELVRYQL------------VMSYLA-P 1595
            ..:.:|:.|....:|||                   .|..|..:|            |:.|.: |
  Fly   613 ISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVLPYYSGP 677

  Rat  1596 IP--------ETPLRQDEFPSARLSLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDTP 1652
            .|        |....:|..|:      :..:|....|..|     ..|......|.:|:...:.|
  Fly   678 QPDDEDYYNKEQITYEDALPN------LIYVSRNHDYRRK-----EFEKVINYEHLLSIKKDEEP 731

  Rat  1653 EKPSALVPENTSLLLDWKAPSNANLT--------------------RFWFELQKWKY-------- 1689
            .:|....|          ||:||.|.                    |...:|.:.||
  Fly   732 TRPPTTTP----------APTNATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYTIRHALPK 786

  Rat  1690 ------SEFYHVKASC-SQGPV----------YVCNIANLQPYTPYNIRVVVVYTTGENSSSIP 1736
                  |....|:..| ::.|:          :.| ::.|:|.|.|.|.:........|..|.|
  Fly   787 CQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYC-LSQLEPETHYRITIRACVEGVVNGCSTP 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ros1	XP_038954373.1	FN3	111..178	CDD:214495
		FN3	211..290	CDD:238020
		FN3	567..663	CDD:238020
		FN3	1036..1142	CDD:238020
		FN3	1449..1527	CDD:214495	22/86 (26%)
		FN3	1551..1630	CDD:238020	21/118 (18%)
		FN3	1650..1741	CDD:238020	25/132 (19%)
		FN3	1746..1839	CDD:238020
		PTKc_c-ros	1948..2209	CDD:270640
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382
		Furin-like	209..332	CDD:279142
		Recep_L_domain	347..461	CDD:279382
		FN3	491..578	CDD:214495	24/94 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910