Protein Alignment FYN and Takl2

DIOPT Version :10

• Sequence 1: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_651090.2
• Gene: Takl2 / 42692
• FlyBaseID: FBgn0039015
• Length: 281
• Species: Drosophila melanogaster
• Alignment Length: 264
• Identity: 72/264 - (27%)
• Similarity: 121/264 - (45%)
• Gaps: 24/264 - (9%)

Human   266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 330
            :|.|.:|..:.:|.|.:|.|:...|. |.::|:|.::.| ...:....|...:.|..|..:|:||
  Fly     8 VPYEEIQTKELIGTGFYGSVYRAVWR-NREIALKRIREG-CEDKKIEREIYQLTKASHVNIVELY 70

Human   331 AVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN---YIHRDL 391
            .....|. ..::.|:::.|||..||......:....:..:.|.|:|.|:||:..|.   .||||:
  Fly    71 GTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDI 135

Human   392 RSAN-ILVGNGLICKIADFG----LARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 451
            :..| :|...||..||.|||    |::.|..|..|.|        :.|||.....:...|.||:|
  Fly   136 KPLNTLLCEKGLKLKICDFGTVVDLSQSISCNAGTCR--------YKAPEVLQGNKPDEKCDVYS 192

Human   452 FGILLTELVTKGRVPYPGMNNR-EVLEQVERGYR--MPC-PQDCPISLHELMIHCWKKDPEERPT 512
            :.|...|:::: :.|:...|.. |:...:..|.|  :.| ...||..:..|:...|..|..:|.:
  Fly   193 WAITFWEILSR-KEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADIVALLYASWDPDISKRFS 256

Human   513 FEYL 516
            .|.:
  Fly   257 MELI 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	72/264 (27%)
Takl2	NP_651090.2	Protein Kinases, catalytic domain	19..268	CDD:473864	69/253 (27%)