Protein Alignment FYN and Csk

DIOPT Version :10

• Sequence 1: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 180/532 - (33%)
• Similarity: 260/532 - (48%)
• Gaps: 98/532 - (18%)

Human    26 SGYRYG------TDPTP----QHYPSFGVT---SIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLR 77
            ||.::|      |.|.|    |.....||:   |.....:.|:....|:|...|||:||.
  Fly   588 SGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSA----- 647

Human    78 TRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
                                                      |.:.|.|......:....:||..
  Fly   648 ------------------------------------------WSSGSTTAMNHASLSPTALAPQQ 670

Human   143 -------SIQAEEWYFGKLGRKDAERQLLSFGNPR--GTFLIRESETTKGAYSLSIRDWDDMKGD 198
                   .:.|..|:.|.:.|.:||..|    .||  |.||:|||....|.|:|.:     ....
  Fly   671 GRSRCEVKLNAMPWFHGSITRDEAEHLL----QPREDGLFLVRESTNFPGDYTLCV-----CFQS 726

Human   199 HVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRL--TDLSVKTK 261
            .|:||:::.|:| ...|.....||.|.|||.||...|.|||.:|:    |.:|:|  .:..:.:|
  Fly   727 KVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLI----KCLPKLGKQEFCINSK 786

Human   262 DV----WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK-PGTMSPESFLEEAQIMKKL 321
            |.    |.||...|||.:.:|.|:||:|.:|... |.|||:|.|| .|.:  :.||.||.:|..|
  Fly   787 DFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTL 848

Human   322 KHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 385
            :||.||:...:| :.:.:|:|||||:||||:|:|:....:.:...:.:..|...|:||.|:|...
  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKK 913

Human   386 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 450
            .:||||.:.|:|:....:.|::||||||   :..|....| |.|||||||||...|||:.|||:|
  Fly   914 VVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMW 974

Human   451 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEY 515
            ||||||.|:.:.||||||.:...:|::.||.||:|..|:.||..::|:|...|..:|.:||||..
  Fly   975 SFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039

Human   516 LQSFLEDYFTAT 527
            |:..|:....||
  Fly  1040 LKVKLQLLNNAT 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35		4/14 (29%)
		SH3_Fyn_Yrk	85..140	CDD:212939	3/54 (6%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	37/101 (37%)
		PTKc_Fyn	261..534	CDD:270655	117/273 (43%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	39/110 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	113/260 (43%)