Protein Alignment FYN and Tak1

DIOPT Version :10

• Sequence 1: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 267
• Identity: 76/267 - (28%)
• Similarity: 141/267 - (52%)
• Gaps: 25/267 - (9%)

Human   271 LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS- 334
            :.|.:::|:|.:|.|....|. :..||:|... .:...:...:|.:.:.::||..::.|:.:.|
  Fly    19 ITLREKVGHGSYGVVCKAVWR-DKLVAVKEFF-ASAEQKDIEKEVKQLSRVKHPNIIALHGISSY 81

Human   335 EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN---YIHRDLRSANI 396
            ::..|::.|:...|||.:||......|..|.:.:..|.|.|.|:||:..|.   .||||::..|:
  Fly    82 QQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNL 146

Human   397 LVGN-GLICKIADFGL----ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 456
            |:.| |...||.|||.    :.::.:|..:|        .|.|||.....::|.|.|::|:.|:|
  Fly   147 LLTNKGRNLKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFSWAIVL 203

Human   457 TELVTKGRVPYPGMNNREVLE-QVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEY----L 516
            .|:::: :.|:.|::|...:: ::.:|.|.|....||..:.:||..|||..||:||:.:|    :
  Fly   204 WEVLSR-KQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM 267

Human   517 QSFLEDY 523
            ...::||
  Fly   268 HEIVKDY 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	76/267 (28%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	75/261 (29%)