Protein Alignment FYN and fyna

DIOPT Version :9

• Sequence 1: NP_001357458.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_001315092.1
• Gene: fyna / 373872
• ZFINID: ZDB-GENE-030903-5
• Length: 537
• Species: Danio rerio
• Alignment Length: 537
• Identity: 496/537 - (92%)
• Similarity: 521/537 - (97%)
• Gaps: 0/537 - (0%)

Human     1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFG 65
            |||||||||||||||:||:.|::|.:|||||:|||||||||||||:|||||||||...||:||||
Zfish     1 MGCVQCKDKEATKLTDERETSVSQHAGYRYGSDPTPQHYPSFGVTAIPNYNNFHAPVSQGVTVFG 65

Human    66 GVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET 130
            |||||||:||||:||||||||||||||||||:||||||.||||||||||:|||||||||||||.|
Zfish    66 GVNSSSHSGTLRSRGGTGVTLFVALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGT 130

Human   131 GYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDM 195
            |||||||||||||||||:|||||||||||||||||.|||||||||||||||||||||||:|||:.
Zfish   131 GYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDET 195

Human   196 KGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKT 260
            |||||||||||||||||||||||||||||||||.|||.|||||||||:||||||||||.||||||
Zfish   196 KGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVHHYSARAAGLCCRLIVPCHKGMPRLADLSVKT 260

Human   261 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||:|||
Zfish   261 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDK 325

Human   326 LVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD 390
            ||||||||||||||||||||:||||||||||||||.|||||||||||||||||||||||||||||
Zfish   326 LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRD 390

Human   391 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 455
            |||||||||:.|:||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   391 LRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 455

Human   456 LTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL 520
            |||||||||||||||||||||||||||||||||||||.||||||:.|||:||||||||||||:||
Zfish   456 LTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPSSLHELMLQCWKRDPEERPTFEYLQAFL 520

Human   521 EDYFTATEPQYQPGENL 537
            ||||||||||||||:||
Zfish   521 EDYFTATEPQYQPGDNL 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35		12/20 (60%)
		SH3_Fyn_Yrk	85..140	CDD:212939	50/54 (93%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	91/99 (92%)
		PTKc_Fyn	261..534	CDD:270655	260/272 (96%)
fyna	NP_001315092.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..34		12/20 (60%)
		SH3_Fyn_Yrk	85..140	CDD:212939	50/54 (93%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	91/99 (92%)
		PTKc_Fyn	261..534	CDD:270655	260/272 (96%)
		Pkinase_Tyr	271..520	CDD:285015	236/248 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341040
Domainoid	1	1.000	493	1.000	Domainoid score	I2860
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1039	1.000	Inparanoid score	I2140
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D165812at7742
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto51945
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3222
SonicParanoid	1	1.000	-	-		X1168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.300