Protein Alignment FYN and drk

DIOPT Version :10

• Sequence 1: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Alignment Length: 215
• Identity: 65/215 - (30%)
• Similarity: 112/215 - (52%)
• Gaps: 36/215 - (16%)

Human    88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYF 151
            :|.:|:.|..:|:|||.|.:..:||| ..:.:|:.|.  ..|:.|.|||||:    .::..:||:
  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62

Human   152 GKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYIT 216
            |::.|.|||: ||| ....|.||||.||::.|.:|||::     ..|.|:|:|:.:.....:::.
  Fly    63 GRITRADAEK-LLS-NKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120

Human   217 TRAQFETLQQLVQHYS----ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRL 277
            . .:|.:|.:||:::.    .|:..:..|.::|....:..|.|.         :|:||.:|..|.
  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDF---------VPQESGELDFRR 175

Human   278 GN-----GQFGEVWMGTWNG 292
            |:     .:..|.|   |||
  Fly   176 GDVITVTDRSDENW---WNG 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939	20/52 (38%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	31/103 (30%)
		PTKc_Fyn	261..534	CDD:270655	11/37 (30%)
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	19/50 (38%)
		SH2_Grb2_like	56..149	CDD:199828	30/100 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	13/49 (27%)