DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FYN and src-1

DIOPT Version :9

Sequence 1:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens
Sequence 2:	NP_001364829.1	Gene:	src-1 / 171722	WormBaseID:	WBGene00005077	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	276/548 - (50%)
Similarity:	363/548 - (66%)	Gaps:	29/548 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG-LTVF 64
            |||:..|        |.|.|..:.....|......|:.:.:....::.:.||   .|.:| ::..
Worm     1 MGCLFSK--------ERRSGGSDMGVSERIDVSRYPRRFQTPQQQTVFHVNN---GGNEGTISQL 54

Human    65 GGVNSSSHTGTLRTRGGTG-----VTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARS 124
            .| .|....|..|..||.|     .|| ||||.|::|.:.||||.||:...:|:.|..|||..|.
Worm    55 NG-TSDGMMGNGRGGGGGGGAQERETL-VALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRH 117

Human   125 LTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI 189
            ..||:|||:|.|:||...:|::||||.||:.|..|||.:||...|:|||||||.|.....::|:|
Worm   118 QRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTI 182

Human   190 RDWDDMK-GDHVKHYKIRKLDNG-GYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPR 252
            ||.||.: |..||||||::||:. ||:||||..|.:||:||::||:...||||:|..|..:..|.
Worm   183 RDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPT 247

Human   253 LTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQI 317
            ..|||..|:..|||||..|.|.::||:|.|||||.|.|.|..:|||||:||||||||:||:||||
Worm   248 RPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQI 312

Human   318 MKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
            ||:..|..||:||||.: |||.||:||||..||||.:|:. :|..|.:..|||||||:|.||.|:
Worm   313 MKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYL 376

Human   382 ERMNYIHRDLRSANILVGNGL----ICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYG 441
            |....:||||.:.|:|||:.:    :.|:||||||| |:|::.|.||.||||||||||||||..|
Worm   377 EERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCG 441

Human   442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLH-ELMIHCWKK 505
            .||:||||||:||||.|::|||:||||||:||||:||||.|||||.|:.||..:: |:::.||.|
Worm   442 NFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDK 506

Human   506 DPEERPTFEYLQSFLEDYFTATEPQYQP 533
            .|:.||||:.|..|.:|||.:|:|.|.|
Worm   507 TPDRRPTFDTLYHFFDDYFVSTQPNYAP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35		4/20 (20%)
		SH3_Fyn_Yrk	85..140	CDD:212939	28/54 (52%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	54/101 (53%)
		PTKc_Fyn	261..534	CDD:270655	166/280 (59%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	26/51 (51%)
		SH2_Src_family	138..240	CDD:199827	54/101 (53%)
		PTKc_Src_like	270..522	CDD:270630	152/252 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I713
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48068
Inparanoid	1	1.050	513	1.000	Inparanoid score	I772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm15767
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3222
SonicParanoid	1	1.000	-	-		X1168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860