DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lamp1 and Lamp1

DIOPT Version :9

Sequence 1:	NP_036989.1	Gene:	Lamp1 / 25328	RGDID:	2989	Length:	407	Species:	Rattus norvegicus
Sequence 2:	NP_610111.3	Gene:	Lamp1 / 35411	FlyBaseID:	FBgn0032949	Length:	318	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	91/328 - (27%)
Similarity:	138/328 - (42%)	Gaps:	84/328 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat   116 NLSD---TQFFPNASSKGPDTVDSTTDIKADINKTYRCVSDIRVYMKNVTIVLWDATIQAYLPSS 177
            |:||   .|..|..||....:..|||..|.   .|.|..|.|                   .|.|
  Fly    37 NVSDLFLEQANPLTSSSSTISTSSTTTEKP---ITTRSTSTI-------------------TPRS 79

  Rat   178 NFSKEETRCPQDQPSPTTGPPSPSPPLVPT--------NPSVSKYNVTGDNGTCLLASMALQLNI 234
            .             :|:|..||.:.|::.|        .||:..:|.     :|::..||.|||.
  Fly    80 T-------------TPSTESPSTTAPVISTTIAPQPYPQPSIGAWNT-----SCIMLQMAAQLNF 126

  Rat   235 TYMKKDNTTVTRAFNINPS-----DKYSGTCGAQLVTLKVGNKSRVLELQFGMNATSSLFFLQGV 294
            ||..::....|..:|| ||     |....:...|.:.|..|.::....|....|.::....|..:
  Fly   127 TYEAREGNFTTGLYNI-PSNASVEDAECKSQTTQFIHLIWGPETSKQSLIMYFNKSNDTTVLSFM 190

  Rat   295 QLNMTL-----PDAIEPTFSTSNYSLKALQASVG-------NSYKCNSEEHIFVSKALA------ 341
            |:::.|     |||.|      |.:::.:..|.|       .||.|...:.|.:::.|.
  Fly   191 QIHLALLPEDFPDAKE------NQTVQLITRSDGAFKTPENMSYHCTRVQKINMTETLDAEQLIG 249

  Rat   342 -LNVFSVQVQAFRVESDRFGSV-EECVQDGNNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHA-G 403
             ::|..|||:|||..:|...|| .:|.....:.::|||||.|||.|:|:|||:||..|:||.: |
  Fly   250 WISVSHVQVEAFRRANDTGFSVGHDCDSSETSDVVPIAVGIALAALILVVLISYLCARRRSTSRG 314

  Rat   404 YQT 406
            |.:
  Fly   315 YMS 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamp1	NP_036989.1	First lumenal domain	22..189		17/75 (23%)
		Lamp	107..407	CDD:279622	91/328 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..211		7/38 (18%)
		Hinge	190..219		9/36 (25%)
		Second lumenal domain	220..371		45/175 (26%)
		TM_EGFR-like	372..401	CDD:213052	17/28 (61%)
Lamp1	NP_610111.3	Lamp	<77..318	CDD:279622	71/273 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12104
eggNOG	1	0.900	-	-		E1_KOG4818
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I5088
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002671
OrthoInspector	1	1.000	-	-		otm46378
orthoMCL	1	0.900	-	-		OOG6_104018
Panther	1	1.100	-	-	O	PTHR11506
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820