DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dmp1 and Su(var)2-HP2

DIOPT Version :9

Sequence 1:	XP_006250684.1	Gene:	Dmp1 / 25312	RGDID:	2508	Length:	504	Species:	Rattus norvegicus
Sequence 2:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	125/684 - (18%)
Similarity:	225/684 - (32%)	Gaps:	231/684 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 PVARYQNTE-----------SESSEERTGNLAQSPPPPMNSESSEESKVSPEGQANSDHTDSSES 71
            |.|..|:||           .:...|::||..::...|::...:..|....:.::|.....:.:.
  Fly  1176 PSAISQSTERKQLLNENPSKKDKKTEQSGNKKEAVVGPLDKTETSSSTNIIDKKSNESFDSAMQP 1240

  Rat    72 GEELGSDRSQYRPAGGLS--KSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSR-LDSD 133
            .:.|....|.:.....:|  |....|.||:.|....|.|:        .|..|..|..|| .|..
  Fly  1241 SDRLNQKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDS--------NPTIRDTGEDSRQTDKK 1297

  Rat   134 EDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDS-------------ESEE 185
            ....||....|||:..:.:..:|.|      |.|.|:.|.:.||:|||             ..:.
  Fly  1298 HQENDTKHEEEDSSKLKANIDETKS------SSEKDAEPISKDSSQDSAKPRLSKPKSRNKRKKN 1356

  Rat   186 YRVGGGSEGESSHGDGSEFDDEGMQ--------------------SDDPGSTRSDRGHTR----- 225
            .:....|..||....|.:.:.|.:|                    :::|..:.::.|..|
  Fly  1357 EKKPNDSIAESDIEGGFQVNTETVQATCSTPSESNKKDMVKSDETNEEPNLSETEIGRIRKRGQA 1421

  Rat   226 ------------------MSSAGIRSEE------------------------------------- 235
                              .|.||:..|:
  Fly  1422 FHIENPKDDLHITPQNENQSIAGVNFEKQVPLPESVESDTPIMKIPTKTYLMCTKNKTSLLSASE 1486

  Rat   236 --------------SKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEE--DDRGELADSNSRET 284
                          ||||..|    |.|::.::|.||.:..:....|::  .|..::..|.::::
  Fly  1487 DPDIVLEPQKLITTSKGDSNP----DLDNANNLETSSTQDPKEHEFSDQTFTDNSDIIPSCTKKS 1547

  Rat   285 Q----------SDSTEDF-----RSKEESRSETQEDTAETQSQEDSPEGQDPSSESS-----EEA 329
            |          ||.|::.     ||.:..|:.::|......|.|:|   |:.:||||     :|.
  Fly  1548 QIVFPTTPTKSSDQTKNSFITPNRSPKSKRNVSKEAKRLDNSFEES---QNAASESSASKVQKEL 1609

  Rat   330 GEPSQ----------------------------------------ESSSESQEGVASESRGD-NP 353
            ..|:.                                        ||..::.....|.|.|: ||
  Fly  1610 RTPTASCRKLRVLIKRTPTSSLPTNSRKSIFKKTPAKSKRLTKILESMEKTPSREPSVSLGEVNP 1674

  Rat   354 DNTSQTGD--------QRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQE-SAQDE 409
            |:.....:        .||.||:|......|     :.|||....:::..|...|:..| ...|.
  Fly  1675 DSDPVAAESVAVLHESDRDLESNEIPNEEVF-----EDTEEASAEDTDNKLKKKEDDHELEVNDI 1734

  Rat   410 DSSSQEGLQSQSASRESRSQESQSE--QDSRSE---------ENRDSDSQDSSRSKEESNSTGST 463
            .::|:..:...|....|.::.:.|:  |:::.|         :..|:..::.:..:..:|.|...
  Fly  1735 CAASKNPITDDSTKDASSNKSTDSDVLQETKDELSNSLINATQGEDTPIKELTEEEVPNNKTVED 1799

  Rat   464 SSSEEDNHPKNIEADNRKLIVDAYHNKPIGDQDD 497
            .|.::: ..|::|.||..|..|........::.|
  Fly  1800 ESKKQE-ILKDLEPDNAALEEDTASTAKAAEEMD 1832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dmp1	XP_006250684.1	DMP1	1..504	CDD:284637	125/684 (18%)
Dmp1	XP_006250684.1	PHA02664	<112..195	CDD:177447	23/96 (24%)
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596
		PTZ00449	<739..1091	CDD:185628
		PTZ00108	<1132..1374	CDD:240271	47/211 (22%)
		PTZ00121	<1720..>2291	CDD:173412	21/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900