DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcc and fra

DIOPT Version :9

Sequence 1:	XP_008770309.2	Gene:	Dcc / 25311	RGDID:	2492	Length:	1447	Species:	Rattus norvegicus
Sequence 2:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster

Alignment Length:	1686	Identity:	486/1686 - (28%)
Similarity:	732/1686 - (43%)	Gaps:	433/1686 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat    13 LAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCS--------AESDRGV 69
            |.|.|.|:||.|             .:|.|..||.|||...|.:|||.|:        .:|...:
  Fly    21 LIFQLIGSSLAS-------------QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNL 72

  Rat    70 P---VIKWK-KDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISR 130
            |   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||..:....|||:||
  Fly    73 PSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSILSR 134

  Rat   131 TAKVMVAGPLRFLSQTESITAFM------GDTVLLKCEVIGDPMPTIHWQKN--------QQDLN 181
            .|.|.:      :.|.:....|:      |.|...:| ::|:    .:||:.        :.||
  Fly   135 PALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEGVKHSVQWLKDDL- 187

  Rat   182 PIPGDS-RVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRIL--SDPGLHRQL--Y 241
            |:|.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|:|..::..:.|.  ||||....:  .
  Fly   188 PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPS 252

  Rat   242 FLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLGGSNLLISNVTDDD 304
            ||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|..:|.||:..|.|
  Fly   253 FLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDID 317

  Rat   305 SGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGD 369
            ||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|||.|.:.|:||||
  Fly   318 SGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGD 382

  Rat   370 VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQL-IVPK-------------- 419
            ::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:..::|:| :||:
  Fly   383 LITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHST 447

  Rat   420 ----------------------------------------------------------------- 419

  Fly   448 KSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLND 512

  Rat   420 ----------------------------------------------------------------- 419

  Fly   513 RRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQ 577

  Rat   420 ----PAIPSS--------------------SILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQ 460
                ||.|.|                    :.|||.|||:|..:|.||||.|||..|.:..|::.
  Fly   578 QKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVV 642

  Rat   461 TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525
            .:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.||.|::|:||||:
  Fly   643 YYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEV 707

  Rat   526 QVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590
            .:.||..|....:.|...|.:.||.|...||.:..||::.:|..:|.:...:...|...|..|:.
  Fly   708 NIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRP 772

  Rat   591 FTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFI 655
            .|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.||:|||.:|.||.|.|.||....:||.|
  Fly   773 HTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQI 837

  Rat   656 TGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
            ||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.:.|..|.|.||||
  Fly   838 TGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDL 902

  Rat   721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIER 785
            ||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:.:...:||:.::.
  Fly   903 DETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKN 967

  Rat   786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGV 850
            |||:..||:||:|.|..|:|.|:|::..||               |:.|...|   ||:..|||:
  Fly   968 LESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDAP---TPLEVPVGL 1014

  Rat   851 QAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTM 915
            :|:.::..::.|.|.|..:.|||..:|.|.|||.:  ..:.|.:|:..:||.|:.....|:|||.
  Fly  1015 RAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQ 1077

  Rat   916 YEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAY 980
            |||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|.||....|:||.|
  Fly  1078 YEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGY 1142

  Rat   981 ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGV--GPLSDPILFRT-- 1041
            .::||.|......||.:|..:|:.....:.:|...|.|||::|||..||.  .|.|..:.:.|
  Fly  1143 NIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSA 1207

  Rat  1042 -LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVT 1105
             :.::.||.:|..                ||                       |..||.|.:..
  Fly  1208 AVTMQEPDTIAKG----------------ID-----------------------NEKLLYIIIAA 1233

  Rat  1106 VGVLTVLVVVIVAVICTRR--SSAQQRKKRATHSASKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1168
            ..|:.::|::.|.::|.|:  ||.:..||      |.:|.:....:||||||||::||:|||:|.
  Fly  1234 TAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292

  Rat  1169 AGTDPAGRGSPIQSCQDLTPVSHSQSESQMGS----KSASHSGQDTEE--AGSSMSTLERSLAAR 1227
            ..|              :|||. |...|..|:    :|..||..:.|.  .|...::|::
  Fly  1293 LHT--------------VTPVC-SDGASSSGALTLPRSVVHSEYEVETPVPGHVTNSLDK----- 1337

  Rat  1228 RATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRG 1292
                         :|..|..::.....|:|..||      |...|.|
  Fly  1338 -------------RSYVPGYMTTSMNGTMERPQY------PRTQYSH------------------ 1365

  Rat  1293 FGAGRSQSVSEGPTAQQQPMLPPAQ-----PEHPSSE------EAPSRTIPTACV------RPTH 1340
              ..||....|...:||....|.:.     ||||...      .|.:......||      :..|
  Fly  1366 --QNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGH 1428

  Rat  1341 PLRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKARSPLLPVSVPT--- 1401
            ||:||:.| .|||.....|...:||.:: :|....|              .:.|....:.|.
  Fly  1429 PLKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YKKPSFSAATPNRLQ 1478

  Rat  1402 ---------------APEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF 1447
                           ||..|.|               :|:::||:||||||.|:|||.:.|
  Fly  1479 GGGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKDLSAITANEF 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcc	XP_008770309.2	None
fra	NP_523716.2	Ig	36..140	CDD:299845	38/106 (36%)
		Ig	<180..222	CDD:299845	19/42 (45%)
		IG_like	257..340	CDD:214653	25/82 (30%)
		IGc2	264..327	CDD:197706	21/62 (34%)
		I-set	344..430	CDD:254352	38/85 (45%)
		Ig	363..428	CDD:299845	31/64 (48%)
		FN3	611..703	CDD:238020	35/91 (38%)
		FN3	711..799	CDD:238020	26/87 (30%)
		FN3	806..897	CDD:238020	38/90 (42%)
		FN3	908..989	CDD:238020	30/80 (38%)
		FN3	1011..1097	CDD:238020	36/87 (41%)
		FN3	1109..1205	CDD:238020	34/95 (36%)
		Neogenin_C	1273..1521	CDD:284094	81/336 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7420
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	786	1.000	Inparanoid score	I493
OMA	1	1.010	-	-		QHG46607
OrthoDB	1	1.010	-	-		D118438at33208
OrthoFinder	1	1.000	-	-		FOG0002773
OrthoInspector	1	1.000	-	-		otm45219
orthoMCL	1	0.900	-	-		OOG6_105369
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1863
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880