Protein Alignment Chrna7 and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_036964.3
• Gene: Chrna7 / 25302
• RGDID: 2348
• Length: 502
• Species: Rattus norvegicus
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 197/536 - (36%)
• Similarity: 304/536 - (56%)
• Gaps: 75/536 - (13%)

  Rat     9 WLALAAALLHVSLQ----GEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKN 69
            || |.:.|:.|:..    .|.:.||.::|.:.||.|.|||.|.:|.:.|.|.|:.:|:::|:|||
  Fly     8 WL-LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71

  Rat    70 QVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNA 134
            |::.:|:||::.|.|:.|||:.::|.|:..:|.|..::|||||:|:|:||..::..:.:|||:..
  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136

  Rat   135 SGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE----ADISSYIPNGE 195
            :|...::||.|::|||.|||.:||||.|.|.:|||||::.|..:.|.:..    .|:|.|..:|.
  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201

  Rat   196 WDLMGIPGKRNEKFYECCKEPYP---DVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD 257
            ||::.:|...|  .|| ....:|   |:|:.:.:||:||:|.:||::|.||||.|.:|||.|||:
  Fly   202 WDIIEVPAYLN--VYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263

  Rat   258 SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDP 322
            :|||::|||::||||.||:|||::|:|.||..:||||:|...|.|:..:|::||||::.::...|
  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328

  Rat   323 DGGKMPKWTRIILLNWCAWFLRMKRPGEDKVR----------PACQHK--------PRRCS---- 365
            ...:||.:.|.|.|::...||.||||.:.::|          ||..|.        |:..|
  Fly   329 RTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGG 393

  Rat   366 ----LASVELSAGAGP-------PTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEH 419
                :..:|||....|       ..|.|.|      ||           |..|.|.  |.:.|..
  Fly   394 KQSKMEVMELSDLHHPNCKINRKVNSGGEL------GL-----------GDGCRRE--SESSDSI 439

  Rat   420 LMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTI 484
            |:        .|:.:|..|.|.:||...|.:|.......:||:.|.|:|||.|..|.:.|...|:
  Fly   440 LL--------SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496

  Rat   485 GILMSAPNFVEAVSKD 500
            ||||.||:..|.|.:|
  Fly   497 GILMDAPHIFEYVDQD 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrna7	NP_036964.3	LIC	4..490	CDD:273305	192/524 (37%)
		Neur_chan_LBD	26..230	CDD:280998	82/210 (39%)
		Neur_chan_memb	237..486	CDD:280999	96/281 (34%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000250|UniProtKB:P49582	260..267		4/6 (67%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	190/522 (36%)
		Neur_chan_LBD	28..236	CDD:280998	82/210 (39%)
		Neur_chan_memb	243..498	CDD:280999	96/281 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910