DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HEPACAM2 and DIP-kappa

DIOPT Version :9

Sequence 1:	NP_001275733.1	Gene:	HEPACAM2 / 253012	HGNCID:	27364	Length:	485	Species:	Homo sapiens
Sequence 2:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	88/431 - (20%)
Similarity:	144/431 - (33%)	Gaps:	105/431 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    95 RPHTMPKYLLG---SVNKSVVPDLEYQHKFTMMPPNASLLINPLQFPDEGNYIVKVNIQGNGTLS 156
            ||||..::.|.   :|.:..:..:.......:|....:|    .:.|.:|.:.         .|.
  Fly    11 RPHTRRRFRLQAEFNVRQLAITIIATAAVTMLMTATPTL----AEIPSKGKHT---------RLD 62

Human   157 ASQKIQVTVDDP-VTKPVVQIHPPSGAVEYVGNMTLTCHVEG--GTRLAYQWLKNGRPVHTSSTY 218
            ..|..|...|.| ..:|:..:     .|....:..:.|.||.  |.::|  |::.......|..:
  Fly    63 TQQTAQEDSDFPRFAEPIANV-----TVSVGRDALMACVVENLKGYKVA--WVRVDTQTILSIHH 120

Human   219 SFSPQNNT------------LHIAPVTKEDIGNYSCLVR-NPVSEME---SDIIMPIIYYGPYGL 267
            :...||:.            |||..|.:.|.|.|.|.|. :|:...:   ..::.|||.   .||
  Fly   121 NVISQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIV---EGL 182

Human   268 QVNSDKGLKVGEVFTVDLGEAILFDCSADSHPPNTYSWIRRTDNTTYII--KH-----GPRLEVA 325
            ..|.         ..|..|:.|...|.|..:|.....| ||.|....:|  :|     |..|.:.
  Fly   183 TSND---------MVVREGQNISLVCKARGYPEPYVMW-RREDGEEMLIGGEHVNVVDGELLHIT 237

Human   326 SEKVAQKTM-DYVCCAYNNITGRQDETHFTVIITSVGLEKLAQKGKSLSPLASITG--ISLFL-- 385
              ||::..| .|:|.|.|.:              ...:.|.........|:.||..  ...:|
  Fly   238 --KVSRLHMAAYLCVASNGV--------------PPSISKRVHLRVQFPPMLSIPNQLEGAYLGQ 286

Human   386 -IISMC-------LLFLWKKYQPYKVIKQKLEGRPETEYRKAQTFSGHEDAL---------DDFG 433
             :|..|       .:..|...:...:|..  ..|...:|....|.||:...:         :|||
  Fly   287 DVILECHTEAYPASINYWTTERGDMIISD--TSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFG 349

Human   434 IYEFVA---FPDVSGVSRIPSRSVPASDCVSGQDLHSTVYE 471
            .|..||   ..:..|..::.....|.:..:|...|.:..|:
  Fly   350 TYRCVAKNSLGETDGNIKLDEMPTPTTAIISEMSLLNRSYD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEPACAM2	NP_001275733.1	Ig	128..>197	CDD:299845	12/69 (17%)
		I-set	172..255	CDD:254352	21/100 (21%)
		IGc2	190..249	CDD:197706	19/73 (26%)
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	20/98 (20%)
		IG_like	82..174	CDD:214653	20/98 (20%)
		IG_like	184..267	CDD:214653	23/108 (21%)
		IGc2	191..255	CDD:197706	20/66 (30%)
		IG_like	282..368	CDD:214653	17/87 (20%)
		Ig	288..367	CDD:143165	16/80 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910