DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HEPACAM2 and igcm-2

DIOPT Version :9

Sequence 1:	NP_001275733.1	Gene:	HEPACAM2 / 253012	HGNCID:	27364	Length:	485	Species:	Homo sapiens
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	86/378 - (22%)
Similarity:	151/378 - (39%)	Gaps:	90/378 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGQDAFMEPFGDTL--------GVFQCKIYLLLFDIVANCLLLRFKLSVSSYEIWKKGACSGLKV 57
            :.:|.|:   |.|:        ||:|             |::.:|....:..|   ||..:.|.|
Worm    75 LARDGFL---GITIHSVTDGDAGVYQ-------------CIVTKFSKQPTRPE---KGLSAKLVV 120

Human    58 TVPSHTVHGVRGQALYLPVHYGFHTPASDIQIIWLFE-RPHTMPKYLLGSVNKSVVPDLEYQHKF 121
            .||...:...:...::..|       .:|:    :|| :....|.           |::.:....
Worm   121 NVPPVIISPSKNAIIHKKV-------GADL----IFECKAEGAPS-----------PEITWSRNE 163

Human   122 TMMPPNASLLINPLQFPDEGNY-IVKVNIQGNGTLSASQKI-QVTVDD--PVTKPVVQIHPPSGA 182
            .::..:..|.::.|:..|:|.| .:.|||:||.|.|...:. :.|:.|  |:.|.|::     |:
Worm   164 QIISTSPVLTLSNLEEGDKGLYTCLAVNIEGNSTSSIDVRFTKATILDLIPLNKTVIE-----GS 223

Human   183 VEYVGNMTLTCHVEG-GTRLAYQWLKNGRPVHTSST-YSFSPQNNTLHIAPVTKEDIGNYSCLVR 245
                 |:...||... .|.::|.||...:|:.|:|. ...:.::..|.:..|.|.|.|.|:|..:
Worm   224 -----NVFWHCHANAQATAISYSWLFEKKPIKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEAK 283

Human   246 NPVSEMESDIIMPIIYYGPYGLQVNSDKGLKVGEVFTVDLGEAILFDCSADSHP-PNTYSWIRR- 308
            |...|..|......::|.|..|..:.       .|.||..|......|...::| |.:|:|.:.
Worm   284 NSAGETTSSTAYLHVFYPPEPLSSHQ-------PVQTVASGRNTTVSCDVIANPTPTSYTWSKNG 341

Human   309 ----TDNTTYIIKHGPRLEVASEKVAQKTMDYVCCAYNNITGRQD--ETHFTV 355
                |..:::||       ::..|.....: |.|.| :||.|:..  |||..|
Worm   342 HYLPTQASSHII-------ISYAKPGDGGI-YGCQA-DNIAGKGSIVETHLIV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEPACAM2	NP_001275733.1	Ig	128..>197	CDD:299845	21/72 (29%)
		I-set	172..255	CDD:254352	22/84 (26%)
		IGc2	190..249	CDD:197706	17/60 (28%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	8/41 (20%)
		Ig	124..200	CDD:386229	17/97 (18%)
		IG_like	214..298	CDD:214653	24/93 (26%)
		Ig_3	309..371	CDD:372822	16/77 (21%)
		Ig	389..467	CDD:386229
		FN3	476..548	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910