DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STXBP4 and stxbp4

DIOPT Version :9

Sequence 1:	XP_016879899.1	Gene:	STXBP4 / 252983	HGNCID:	19694	Length:	571	Species:	Homo sapiens
Sequence 2:	NP_001037969.1	Gene:	stxbp4 / 733742	XenbaseID:	XB-GENE-973737	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	560	Identity:	267/560 - (47%)
Similarity:	362/560 - (64%)	Gaps:	69/560 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESM 78
            |.:||. |:||:.|||.|||.::|||:|.|.||:||::|||||||:||||||.||||||||||.:
Frog     7 LSEDPV-QIITVTKETSLGLSLVGGISRAEEPLIYIKDIIPGGDCHKDGRLKSGDQLVSVNKELL 70

Human    79 IGVSFEEAKSIITGAKLSTRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFS 143
            :|||.|:||.|:..|||  |....||||:|| ..:.:|...|.....::.:.::.|     :..|
Frog    71 VGVSCEQAKCILNRAKL--RKGPVWEIAYIR-PVEELQNHILPADGCVKGAMDFMP-----NRIS 127

Human   144 SPPEILIPKTSSTPKTNNDILSSCELLSHTVRLIPGIQSKKIKTGYNKTVQIPITSENSTVGLSN 208
            ||         |..|.|                   :.|:.||:.:  ..:.|:
Frog   128 SP---------SAAKAN-------------------LSSESIKSQH--AAESPL----------- 151

Human   209 TDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGD 273
                ||.::.||.:|::|||||:|.|.||||||||||||.|.:||.:.::|.::.|:.|||.:||
Frog   152 ----SAASQTYGEEEQLSLNPSIRIKVEKLEMALNYLGIHPNEEQKRLMKQDLKIDANGTVEYGD 212

Human   274 FVQVARNLFCLQLDEVNVGA-------HEISNILDS-----QLLPCDSSEADEMERLKCERDDAL 326
            ||||||.||.||:.|.:...       .:|::::||     .|.|   |.:|:.|:|:.||::|.
Frog   213 FVQVARKLFTLQIKEGDFKQEMTLSEDRDITSLIDSNANKDSLHP---SVSDDPEQLRRERNEAY 274

Human   327 KEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEV 391
            .|:..|||:|.:|:|.|.||:|||:|||||||..:||.||||:||||||.||.||.|||.|||||
Frog   275 AELKKLKERLQKSEKNRSQLSEELENVKQEAKGAIEEARALRNRIHLAEVAQSQASGMETDYEEV 339

Human   392 IRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQ 456
            ||||||::.||||||...|.|.|::|||||:|..||.|||||||||||.||.:||||..|.|.:.
Frog   340 IRLLEAEVAELKAQLLKCSGQTKDNVQDLKRRASVLCCQLRKSEMARKAFEVTTEKLQQFAENVC 404

Human   457 EVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWE 521
            ::.||:|..:.|.||:.:..:|:|.:|.|..:...|.|.:|.|:::|.:|||:::|..|||||.|
Frog   405 DIISDDSANMLNPSEKGSPFSSKTLMTRLKPSRHDIIAAMAAEARDLARSVRSMVDTQCLPYGLE 469

Human   522 EAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEED 561
            ||||||||||:||||||||:|.:||:|.|.....|:.:.|
Frog   470 EAYTADGIKYYINHVTQTTTWTNPVLSTLLSGELEDIQGD 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STXBP4	XP_016879899.1	None
stxbp4	NP_001037969.1	PDZ_signaling	12..86	CDD:238492	48/74 (65%)
		SMC_prok_A	<159..>354	CDD:274009	108/197 (55%)
		COG4372	264..>400	CDD:226809	89/135 (66%)
		WW	464..493	CDD:395320	24/28 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	301	1.000	Domainoid score	I9258
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7963
Inparanoid	1	1.050	468	1.000	Inparanoid score	I8132
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124334at7742
OrthoFinder	1	1.000	-	-		FOG0010801
OrthoInspector	1	1.000	-	-		oto151043
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8334
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160