Protein Alignment STXBP4 and Patj

DIOPT Version :9

• Sequence 1: XP_016879899.1
• Gene: STXBP4 / 252983
• HGNCID: 19694
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_477342.1
• Gene: Patj / 44100
• FlyBaseID: FBgn0067864
• Length: 871
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 127/626 - (20%)
• Similarity: 220/626 - (35%)
• Gaps: 171/626 - (27%)

Human    21 QMITIAKE-TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFE 84
            |.|.:..: ||||..::|.  ||.|  |.::.|:|||...|||||:.||.::.:...::..:..|
  Fly   148 QAIELVNDGTGLGFGIIGA--RNSG--VIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSE 208

Human    85 EAKSIITGAKLSTRLESAWEIAFIRQKSDNIQPENLSC---TSLIEASGEYGPQASTLSLFSSP- 145
            :..:::..:....||..|      |....::.....:.   |:::.......|......|.|:.
  Fly   209 QVAAVLRQSGTHVRLVVA------RPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGY 267

Human   146 PEIL-IPKTSSTPKTN------------------NDILSSCELLSHTVRLIPGIQSKKIKTGYNK 191
            |||. ...|:|||:|.                  |..|.....|..|.:|  .::.||...|...
  Fly   268 PEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKL--QVELKKDANGLGI 330

Human   192 TVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPS-VRFKAEKLEMALNYLGIQPTKEQHQ 255
            |:...:..:....|:....|:.....:  |..:|.:|.. :....:.|:...|:..::..|:..|
  Fly   331 TIAGYVCEKEELSGIFVKSVSPGSAAD--LSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQ 393

Human   256 A----------------LRQQVQADSK------GTVSFGDF-----------VQVARNLFCLQLD 287
            .                |:|.:.|:.|      ||.|....           ...:|:: ..:|:
  Fly   394 VVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSI-TRELE 457

Human   288 EVNVGAHEI-----------------------------------SNILDSQLLP-CDSSEADEME 316
            |..:.|.|.                                   :.|:.::::| .|.:||....
  Fly   458 EEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSG 522

Human   317 RLKCER--------DDALKEVNTLKEKLLESD-----KQRKQLTEELQNVKQEAKAVVEETR--- 365
            .:...:        |||..|:....:|::.||     .|.|:.......:..|....||..|
  Fly   523 VITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVR 587

Human   366 ------------------ALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQ 412
                              .|||...|.|....:..|  |::.||:.:|:    ||...:.....:
  Fly   588 PHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLG--MNHLEVVAILK----ELPLDVRMVCGR 646

Human   413 NKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNS-TPLSNLSERRAVL 476
            |:.|            ..|..|:...|....:.|.||...:.:.:..||.| ....::::..:|.
  Fly   647 NRNS------------SLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVA 699

Human   477 ASQTSLTPLGRNGRSI-PAT-LALESK-----ELVKSVRAL 510
            |:..|.:.|  ..||: |.| ||:.|.     ||||..|.|
  Fly   700 AAAASFSKL--KSRSLEPLTGLAMWSSQPQIIELVKGDRGL 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STXBP4	XP_016879899.1	None
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	23/75 (31%)
		PDZ_signaling	318..400	CDD:238492	13/83 (16%)
		PDZ_signaling	557..643	CDD:238492	18/91 (20%)
		PDZ_signaling	726..807	CDD:238492	6/13 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010