DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adcy6 and Ac78C

DIOPT Version :9

Sequence 1:	NP_001257714.1	Gene:	Adcy6 / 25289	RGDID:	2035	Length:	1180	Species:	Rattus norvegicus
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	1304	Identity:	386/1304 - (29%)
Similarity:	608/1304 - (46%)	Gaps:	300/1304 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat   140 SKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTF------------HAAPALPQPAY 192
            :..|:.:.|||.|..|..:..|.|| :::.|:..::.::|.|            .:.........
  Fly   304 TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATA 367

  Rat   193 VALLTCASVLFVVLMVVCNRHSFRQDSM-W--VVSYVVLGILAAVQVGGALAANPRSPSAGLWCP 254
            :....|..:..:.:..:.....|..:.: |  |.::|:..|...|..|...|.....    :|..
  Fly   368 ITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYL----VWYI 428

  Rat   255 VFFVYITYTLLPIRMRAAVLSGLGLSTLHL--ILAWHLNNGDPFL-----WKQLGANVVLFLCTN 312
            :|.:::.|.:||:.::..|:.|...::.||  |....|.:|:..:     ..|:.||.:|:...|
  Fly   429 LFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAIN 493

  Rat   313 AIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 375
            ..|:.|.|..:..||.||.||...::.:...:.|.::.::||.|:||..|..:::.::....:
  Fly   494 VAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPT 558

  Rat   376 -DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 439
             :..|:|:|:...||||||||||:|||.|||:.:||:||..||:||||||::|.:|||||:|:||
  Fly   559 VETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLG 623

  Rat   440 DCYYCVSGLP----EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 500
            |||||||...    :.|.|||.|.||.|:.||:||..||..|.|::|||:|||||.|.|||||.:
  Fly   624 DCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNK 688

  Rat   501 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLIL 565
            ||.||||||||.:|||||:||..||:||:.|||:.||..||||||.||.|:.:||...::|:||.
  Fly   689 KWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIK 753

  Rat   566 GASQKRKEEK------------------------AMLVKLQRTRANSMEGL-------------- 592
            .....|.:.:                        |:...:..:.:.|:.|:
  Fly   754 RTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRS 818

  Rat   593 --------MPRWVPDRAFSRTK------------------DSKAFRQ----MG------------ 615
                    :|...|.:...:.:                  ||:..|.    ||
  Fly   819 LEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGP 883

  Rat   616 -------------------------------------------IDDSS----------KENRGAQ 627
                                                       |:|.|          |.....:
  Fly   884 CGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPE 948

  Rat   628 DALNPED-------------------EVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKY 673
            |.||..|                   |:|||:.:.|...|..::|::::..:.|.|:.:..|:|:
  Fly   949 DGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKF 1013

  Rat   674 SRKVDPRFGAYVACALLVFCFICFIQFLVFPH-SALILGIYAGIFLLLLVTVLICAVCSCGSFFP 737
            .:..:..|.:.:.|..:::.|:...|.::.|. :.||:.:..|..:|....||:.|....|  .|
  Fly  1014 CQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPG--LP 1076

  Rat   738 NALQRLSRSIVRSRVHST--------------AVGV--------------FSVLLVFISAIANM- 773
            ..|:..|..:|..|...|              |:|:              .|..|..:|..:|:
  Fly  1077 RCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNIS 1141

  Rat   774 -------------FTCSH------------TPL--------------RTCAARMLNLTP------ 793
                         .|..|            |||              .|..|..|||||
  Fly  1142 MTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSH 1206

  Rat   794 ------SDVTACHLRQLNYSLGLEAPLCEGTAPT---CSFPEYFVGSVLLSLLASSVFLHISSIG 849
                  ::..:..|..|:||   :|.:.:.::..   |:.|||.|.:.:|.|::.:..|.:..:.
  Fly  1207 RPYTLTTNGHSVSLSNLSYS---DASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLV 1268

  Rat   850 KLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVIL 914
            |.:|...:...|..|:::                  ...|.::|..::...:| :.|.....::|
  Fly  1269 KALMALAMVAFYTTLIMM------------------KFGSGDSFSLVELSRLG-MPLGVQMLILL 1314

  Rat   915 LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRN 979
            :.|.:.:..||:.||.|:||||:||.||..|...|:..:|.|..|:.||||..||.::|:.| ..
  Fly  1315 ISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HT 1378

  Rat   980 DELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1044
            ||||.:......||||||.||.:||.| :.:| |..|:|:|||||.||||::.|.||..:|||||
  Fly  1379 DELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKT 1441

  Rat  1045 IGSTYMAASGLN---ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVA 1106
            :|:|||||:|||   .....:.....:..|.::|..:.::::.||..:|||||:::|:..||:|:
  Fly  1442 VGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVS 1506

  Rat  1107 GVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTT 1171
            ||||||||.||||||||||:|||||||...|:||..:..::|.::||....||.:.|||||.|||
  Fly  1507 GVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTT 1571

  Rat  1172 YFLN 1175
            ::::
  Fly  1572 FYVH 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	54/264 (20%)
		CYCc	346..541	CDD:214485	110/201 (55%)
		Guanylate_cyc	382..566	CDD:278633	115/187 (61%)
		DUF1053	594..680	CDD:283888	26/191 (14%)
		CYCc	956..1157	CDD:214485	99/203 (49%)
		Guanylate_cyc	982..1176	CDD:278633	97/197 (49%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	54/251 (22%)
		CYCc	526..729	CDD:214485	110/202 (54%)
		Guanylate_cyc	566..753	CDD:278633	114/186 (61%)
		DUF1053	929..1020	CDD:283888	18/90 (20%)
		CYCc	1353..1554	CDD:214485	99/203 (49%)
		Guanylate_cyc	1381..1576	CDD:278633	97/197 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810