DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp24a1 and Cyp12a4

DIOPT Version :9

Sequence 1:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus
Sequence 2:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	151/548 - (27%)
Similarity:	255/548 - (46%)	Gaps:	71/548 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 LRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGE---TRNVTSLPGPTNWPLLGSLLEIFWK 76
            :|....|.|..::..|.|:..|....|.......|.|   .:....:|....|.|   .:::...
  Fly     4 VRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWAL---SMKMSMP 65

  Rat    77 GGLKKQHDTLAEY---HKKYGQIFRMK--LGS--FDSVHLGSPSLLEALYRTESAHPQRLEIKPW 134
            ||..|..:.:..:   .:.||.||.|.  :|:  |.|.|  :|...|.::|.|...|.|......
  Fly    66 GGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTH--NPQDFEVVFRNEGVWPNRPGNYTL 128

  Rat   135 KAYR-DHRNEAY----GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELC 194
            ..:| ::|.:.|    |::..:|:.|...|:.....||:|..:....||:::|..:|::|:.||.
  Fly   129 LYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELR 193

  Rat   195 D-ERGRIPDLYSE-LNKWSFESICLVLYEKRFGLLQKETEE-EALT--------FITAIKTMMST 248
            | :....||.:.: :|:|:.||:.:|..:|:.|||:...:| |||.        ||.:|...|..
  Fly   194 DPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP 258

  Rat   249 FGKMMVTPVELHKRLNTKV--WQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHL 311
            .....:...:| |||...:  .|..|||:          :|..::|..::.....:....:|..|
  Fly   259 SPWRYIKTPKL-KRLMRALDGIQEVTLAY----------VDEAIERLDKEAKEGVVRPENEQSVL 312

  Rat   312 SK------KELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAE- 369
            .|      |.......::.:|.|:||:::...:|..|::||:.|.||.:||..|||:..:...|
  Fly   313 EKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEA 377

  Rat   370 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGT---VLTLNTQVLGSSEDNFED 431
            .::|:|||:||:|||.||.|.:....|.|.:..||..|.:|.||   ::.||..   :.::.|..
  Fly   378 SMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNAL---TRDEYFPQ 439

  Rat   432 SHKFRPERWLQKE------------KKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484
            :.:|.|||||:..            |..|||..||||.|.|||:|:|:.|::|.|....:|:.::
  Fly   440 ASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFN 504

  Rat   485 IVATDNEPVEMLHLGILVPSRELPIAFR 512
            :  ..|.|.|......|:....:|:.|:
  Fly   505 V--EFNYPTENAFRSALINLPNIPLKFK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	134/461 (29%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	136/477 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.770