DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smo and fz2

DIOPT Version :9

Sequence 1:	NP_036939.1	Gene:	Smo / 25273	RGDID:	3726	Length:	793	Species:	Rattus norvegicus
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	193/753 - (25%)
Similarity:	308/753 - (40%)	Gaps:	200/753 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat    16 RLLQLLL-LVLL-----------------GGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSPPP 62
            ||..|:| ||||                 ||.|.|.  .|....|.|       ....||....|
  Fly     5 RLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGG--HGLDASPAP-------GYGVPVIPKDP 60

  Rat    63 PLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQ 127
            .|        .||.:...:|.|  :.|..|:.....:.::|:||        || ...:.|.:::
  Fly    61 NL--------RCEEITIPMCRG--IGYNMTSFPNEMNHETQDEA--------GL-EVHQFWPLVE 106

  Rat   128 ----P----LLCAVYMPKC-ENDRVELP-SRTLCQATRGPCAIVERERG--WPDFLRCTPDHFP- 179
                |    .||::|.|.| |:....|| .|::|:..|..||.:.::..  ||:.:.|  :|.|
  Fly   107 IKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMAC--EHLPL 169

  Rat   180 EGCPNEV---------------------------------------------------------- 186
            .|.|:.:
  Fly   170 HGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRG 234

  Rat   187 QNIK--FNSSGQ----------CEAPLV---------------RTDNPKSWYED--------VEG 216
            :|.|  .|..|:          |.:||:               ...:|..||.:        |..
  Fly   235 RNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPN 299

  Rat   217 CGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAVILFYVNACF 278
            |||.|:.|.|:..|......:||.:   :|||   ||.||.||:.|.... :||...:.:::||:
  Fly   300 CGIPCKGPFFSNDEKDFAGLWIALW---SGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACY 360

  Rat   279 FVGSIGWLAQ-FMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYA 342
            |:.::|:|:: |:.  ..||.|  ||.:.  ..:|:...||.::|::.|:..||..:|:|:|::.
  Fly   361 FMVAVGYLSRNFLQ--NEEIAC--DGLLL--RESSTGPHSCTLVFLLTYFFGMASSIWWVILSFT 419

  Rat   343 WHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRA 405
            |   |.|.|..:  :.::..:.||||..|.:|.|.:||:|.::.||||.:.|||:||..|..:..
  Fly   420 W---FLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLK 481

  Rat   406 GFVLAPIGLVLIVGGYFLIRGVMTLFSIKS---NHPGLLSEKAASKINETMLRLGIFGFLAFGFV 467
            .|||||:.:.|::|..||:.|.::||.|:|   ...|:.:...|.|:.:.|:|:|||..|.....
  Fly   482 TFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPA 546

  Rat   468 LITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGT 532
            .|...|:.|:.....:|.::    :.|......| |.|||:        .|:|:  :..|.....
  Fly   547 TIVIGCYLYEAAYFEDWIKA----LACPCAQVKG-PGKKPL--------YSVLM--LKYFMALAV 596

  Rat   533 GIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHT 597
            ||....|:|:..||..|||.|.||.|    .|.|...:    :|..|:|..:.:|.......|..
  Fly   597 GITSGVWIWSGKTLESWRRFWRRLLG----APDRTGAN----QALIKQRPPIPHPYAGSGMGMPV 653

  Rat   598 VSHDGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGA 635
            .|..|.:....: .....|.|:|....|:...|.::.|
  Fly   654 GSAAGSLLATPY-TQAGGASVASTSHHHLHHHVLKQPA 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smo	NP_036939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..61		5/25 (20%)
		CRD_SMO	70..200	CDD:143560	38/212 (18%)
		Frizzled	225..554	CDD:279827	106/337 (31%)
		Interaction with BBS5 and BBS7. /evidence=ECO:0000250\|UniProtKB:P56726	542..573		11/30 (37%)
		Interaction with DLG5. /evidence=ECO:0000250\|UniProtKB:P56726	585..597		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..702
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	33/131 (25%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	106/337 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820