Protein Alignment X11L and APBA3

DIOPT Version :10

• Sequence 1: NP_001285376.1
• Gene: X11L / 252671
• FlyBaseID: FBgn0026313
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_006723013.1
• Gene: APBA3 / 9546
• HGNCID: 580
• Length: 650
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 225/684 - (32%)
• Similarity: 309/684 - (45%)
• Gaps: 197/684 - (28%)

  Fly   434 PVLEDGLSSGHASDTENNVSVVC---DKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDA 495
            |.:....|...|.|.|....::.   |....||..|:....|:..|:|.|             ::
Human     4 PTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELD-------------ES 55

  Fly   496 SQSALISDFASLP---MPPAPPPSSPPQIEIAD----ASESMTMVPDADNPLDSHYGAVYAAA-- 551
            |...|:..|.:||   :.|: |..:|..:.||.    ||:.:.         |:| |.:.|.|
Human    56 SLQELVQQFEALPGDLVGPS-PGGAPCPLHIATGHGLASQEIA---------DAH-GLLSAEAGR 109

  Fly   552 ---LGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLP 613
               ||..|.|:..               |||...|  |.::.....||..:...|
Human   110 DDLLGLLHCEECP---------------PSQTGPE--EPLEPAPRLLQPPEDPDE---------- 147

  Fly   614 TDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDI 678
             |.|||.||          :||:|::|
Human   148 -DSDSPEWV----------EGASAEQE-------------------------------------- 163

  Fly   679 ASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQF 743
                  ...|.:::|.|...:.|              .:||..|         .....|||.|..
Human   164 ------GSRSSSSSPEPWLETVP--------------LVTPEEP---------PAGAQSPETLAS 199

  Fly   744 TKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQ 808
            ..:|                   :...|..:.:.|::||:|.||||||||||.|..|..||||.|
Human   200 YPAP-------------------QEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQ 245

  Fly   809 AEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMA 873
            |.||:.|:|  ||:||:||.||||||:||::|.||..|.:|.||||||.||||.||||.::||||
Human   246 AREAMDRVK--APDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADIGCVLVLMA 308

  Fly   874 RRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKH-NRTPKMICHVFESDEAQFIAQSIG 937
            |||              |...|.|             ..| .|..||:||||.:::||.|||:||
Human   309 RRR--------------LARRPAP-------------QDHGRRLYKMLCHVFYAEDAQLIAQAIG 346

  Fly   938 QAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGV 1002
            |||..||.:||:.:||:    ..::.......:..:...:|:.|:..:..:||.:.|.:||.|||
Human   347 QAFAAAYSQFLRESGID----PSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGV 407

  Fly  1003 VIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA 1067
            .:|||||||:|||.|||||:..|.|.|.|.|:|||:|.||||.|||||||:.||:.:|..|:||:
Human   408 ALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTS 472

  Fly  1068 VKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVI 1101
            |..::|.||||....|.||.|..||||.|::|::
Human   473 VTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIV 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	92/179 (51%)
		PDZ1_APBA1_3-like	988..1071	CDD:467203	50/82 (61%)
		PDZ2_APBA1_3-like	1082..1154	CDD:467255	10/20 (50%)
APBA3	XP_006723013.1	PTB_X11	212..364	CDD:269919	93/184 (51%)
		PDZ1_APBA1_3-like	393..478	CDD:467203	50/84 (60%)
		PDZ_canonical	482..>506	CDD:483948	12/23 (52%)