DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment X11L and LNX1

DIOPT Version :9

Sequence 1:NP_001285376.1 Gene:X11L / 252671 FlyBaseID:FBgn0026313 Length:1170 Species:Drosophila melanogaster
Sequence 2:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens


Alignment Length:917 Identity:171/917 - (18%)
Similarity:264/917 - (28%) Gaps:373/917 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 LEANLRRHSRNFTLSPETTDYDSNCG-DLDSLSNDINCPTDFGKLYTSM------------PVLE 437
            ||.|      :|...||..|.|..|. .|.:|.:.::.|.  |..|.::            |:..
Human    23 LEEN------HFYSYPEEVDDDLICHICLQALLDPLDTPC--GHTYCTLCLTNFLVEKDFCPMDR 79

  Fly   438 DGLSSGHASDTE-------NNVSVVCDKQQSSQSQPVHEHNGNG-ERLENDYNVMS----ASLAT 490
            ..|...|...:.       |.:.|.|         |..||.... :|.:.:::..:    ||...
Human    80 KPLVLQHCKKSSILVNKLLNKLLVTC---------PFREHCTQVLQRCDLEHHFQTSCKGASHYG 135

  Fly   491 LTTD---ASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAAL 552
            ||.|   .||.......|||   .|..||  |::..|.....||..|..|||       .|.:  
Human   136 LTKDRKRRSQDGCPDGCASL---TATAPS--PEVSAAATISLMTDEPGLDNP-------AYVS-- 186

  Fly   553 GGTHTEKSAGSGL-GVTPVTAGGS------------LPSQAASEIQEAMKEIRSALQRAKTQPEK 604
                   ||..|. .::||.:|.|            :.|::..:|..|:    |.|:|.|:....
Human   187 -------SAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRAL----SVLRRTKSGSAV 240

  Fly   605 LKFCD------------EVLP----TDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQ 653
            ....|            ||.|    ..||..:      |:|...:     .:|...|.. ||:|.
Human   241 ANHADQGRENSENTTAPEVFPRLYHLIPDGEI------TSIKINR-----VDPSESLSI-RLVGG 293

  Fly   654 QRHD-----EQDFFADQSLA-DNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQG 712
            ....     .|..:.|..:| |.....|..|..   :||...:|        .|..|:...:||.
Human   294 SETPLVHIIIQHIYRDGVIARDGRLLPGDIILK---VNGMDISN--------VPHNYAVRLLRQP 347

  Fly   713 IGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSI----------------KSLKDSANSD 761
                        ||::..|.:     .:.:|.....|..                ||..:.....
Human   348 ------------CQVLWLTVM-----REQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGI 395

  Fly   762 KKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCE--------GQPTKSTRMMQAEEAVSRIKA 818
            |..:..::.|:....||..||.:|...|.....|..        |.|..:..::||.|       
Human   396 KLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE------- 453

  Fly   819 LAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVV 883
                      ..|.|.:|.:                                  .|:|       
Human   454 ----------RRVHLVVSRQ----------------------------------VRQR------- 467

  Fly   884 DPSITSPLG----DVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAY 944
            .|.|....|    ...:||.||..:.|| ||.     |.:.||                      
Human   468 SPDIFQEAGWNSNGSWSPGPGERSNTPK-PLH-----PTITCH---------------------- 504

  Fly   945 MEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESG- 1008
                                                      :|.|.:.|..||.||:.:.... 
Human   505 ------------------------------------------EKVVNIQKDPGESLGMTVAGGAS 527

  Fly  1009 ---WGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKF 1070
               |.  ||..|| ::...|..:|.|::..||.|:.::|:.|..:..|...:.::...:...:| 
Human   528 HREWD--LPIYVI-SVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLK- 588

  Fly  1071 TVVPCPPVVEVK----------------------------------------------ILRPKAL 1089
                   .:|||                                              :||....
Human   589 -------ALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTA 646

  Fly  1090 FQLGFSVQNG----------VICSLLRGGIAERGG-VRVGHRIIEINNQSVVAVPHDTIVKLLSS 1143
            ..|||.:..|          .|.|::.|..|...| :|.|..::.:|.:|...:.|..:.:||..
Human   647 GSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKE 711

  Fly  1144 SVGEILM 1150
            ..|.|.:
Human   712 LKGRITL 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
X11LNP_001285376.1 PTB_X11 775..954 CDD:269919 31/190 (16%)
PDZ_signaling 988..1065 CDD:238492 21/80 (26%)
PDZ_signaling 1092..1151 CDD:238492 18/70 (26%)
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693 8/42 (19%)
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 11/51 (22%)
NPXY motif 181..184 2/9 (22%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 14/70 (20%)
PDZ_signaling 272..355 CDD:238492 22/117 (19%)
PDZ_signaling 380..460 CDD:238492 18/96 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494 5/18 (28%)
PDZ_signaling 505..588 CDD:238492 21/85 (25%)
PDZ_signaling 637..721 CDD:238492 20/82 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.