DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Apba1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_113967.2	Gene:	Apba1 / 83589	RGDID:	620844	Length:	841	Species:	Rattus norvegicus

Alignment Length:	976	Identity:	351/976 - (35%)
Similarity:	466/976 - (47%)	Gaps:	264/976 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 DHEEERSGTLREKTPTFDYLYEFSETRK-----VLEEFFKA----NPEDEKRYT--------DYT 303
            :.||||...|.....|....:..::|.:     ...:.::|    :.:||..|.        :||
  Rat    69 EEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYT 133

  Fly   304 TES-GDDVASSQPQEYP----------ATPMEQAYIG----QRLARIPKDELYMVHRSPTKKPPS 353
            .:: .:...::|.:..|          ...|..||.|    .||....:||       |..:|.:
  Rat   134 EQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDE-------PYAEPYA 191

  Fly   354 DQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHS---------RNFTLSPETTDYDSN 409
            |..   ..|||...|:         ||..:.|....||.:.         |...|......||..
  Rat   192 DYG---GLQEHVYEEI---------GDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDER 244

  Fly   410 C-GDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGN 473
            . |:.||...:    .:|.. |..|...|         ..|:...:|.:.:||..||.:.:
  Rat   245 SDGESDSPEKE----AEFAP-YPRMDSYE---------QEEDIDQIVAEVKQSMSSQSLDK---- 291

  Fly   474 GERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADN 538
                                                                |:|.|   |:|:.
  Rat   292 ----------------------------------------------------AAEDM---PEAEQ 301

  Fly   539 PLDSHYGAVYAAALGGTHTEK-----SAGSGLGVTPVTAGGSLPSQAASE-----IQEAMKEIRS 593
            .|:.      |...||.|.:.     .||....|.. |.|||...|..|:     |..|:|:|:.
  Rat   302 DLER------APTPGGGHPDSPGLPAPAGQQQRVVG-TPGGSEVGQRYSKEKRDAISLAIKDIKE 359

  Fly   594 ALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDE 658
            |::..||:..:..:    .|.:|..|:||.|:            |..|..|.:..|.:
  Rat   360 AIEEVKTRTIRSPY----TPDEPKEPIWVMRQ------------DISPTRDCDDQRPV------- 401

  Fly   659 QDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPD 723
                                          |.::|:| .:|.|         .|..:|:||..|.
  Rat   402 ------------------------------DGDSPSP-GSSSP---------LGAESSITPLHPG 426

  Fly   724 ICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARY 788
                 ..|:.|.:...:......||                 .....|..:|:.||:|::|.|.|
  Rat   427 -----DPTEASTNKESRKSLASFPT-----------------YVEVPGPCDPEDLIDGIIFAANY 469

  Fly   789 LGSTQLVCEGQPTKSTRMMQAEEAVSRIKAL---------APEGESQPSTEVDLFISTEKIMVLN 844
            ||||||:.:..|:|:.|||||:|||||||..         ||||||||.|||||||||::|.|||
  Rat   470 LGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLN 534

  Fly   845 TDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEP 909
            .|.:|.||||.|||||||||||::|||||||| :|.|                 ..:|......|
  Rat   535 ADTQEPMMDHPLRTISYIADIGNIVVLMARRR-MPRS-----------------NSQENVEASHP 581

  Fly   910 LSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIF 974
            .....|..|||||||||::||.|||||||||.|||.|||:||||..|.|::: :|.::||:|:::
  Rat   582 SQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQK-EYSDLLNTQDMY 645

  Fly   975 GDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQL 1039
            .|:|..|:|.|..|:|.:.|.||||||||||||||||:||||:|||:|..|.|.:.|:||||||:
  Rat   646 NDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQI 710

  Fly  1040 IAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSL 1104
            ::|||.||||||||||||.|:..|||:.||..:|.||||..|.|.||...:|||||||||:||||
  Rat   711 MSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSL 775

  Fly  1105 LRGGIAERGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIY 1169
            :||||||||||||||||||||.|||||.||:.||.:||::||||.|||||.:|:||||.||.|:|
  Rat   776 MRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVY 840

  Fly  1170 I 1170
            |
  Rat   841 I 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	107/187 (57%)
		PDZ_signaling	988..1065	CDD:238492	53/76 (70%)
		PDZ_signaling	1092..1151	CDD:238492	47/58 (81%)
Apba1	NP_113967.2	Munc-18-1 binding	229..317		27/166 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..348		34/190 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..439		24/142 (17%)
		LIN-2/CASK binding	377..440		21/126 (17%)
		PTB_X11	456..627	CDD:269919	108/188 (57%)
		Autoinhibitory helix linker	630..645		5/15 (33%)
		PDZ	660..743	CDD:395476	56/82 (68%)
		PDZ_signaling	749..822	CDD:238492	53/72 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3621
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1292
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8963
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820