DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and PDZD7

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	1154	Identity:	209/1154 - (18%)
Similarity:	351/1154 - (30%)	Gaps:	441/1154 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTP----AST----- 62
            |..|..|:.:..|:..:.|..|               .||:...:.|..|..|    ||:
Human    18 SSGSLSSLSSRGHLGSDSGSTA---------------TRYLLRKQQRLLNGPPRGIRASSPMGRV 67

  Fly    63 -VLNSP------------DLNGELSYVPLQGLSPSGGGVQGSGSY------GSNAGR-------- 100
             ::|||            .:..|.|.....|.|..||...|.|.:      ||:|.|
Human    68 ILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDK 132

  Fly   101 ------------DSGS---YYYQRPQLHQI--RLGRSPGSQFETR-----DVLPQGLA---SPGS 140
                        ..||   ......:||.:  |:||.||.:|...     ||:.:.|.   ...:
Human   133 ITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGST 197

  Fly   141 PTDVGKADGQ-------------CL----RDGEI------------------------------- 157
            |:|....||.             ||    |.|:.
Human   198 PSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAAN 262

  Fly   158 -VVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLP-----IAEY------------------ 198
             |.||||..:...:...||     ..::...|..|:.|     ::||
Human   263 GVRFDDISHSQAVEVLKGQ-----THIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPAS 322

  Fly   199 ----------EGSPRRFGSQPNTN-TITMG--GPRKRPPGFPQ-------------------RVS 231
                      ..:|...||.|:.. .|.:|  .|..|.||:.:                   .|.
Human   323 ESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQTEPDAGGRVETWCSVR 387

  Fly   232 PTTSVANNATAAAKASVGNLIDLVDHEEERSGTL----REKTP-----TFDYLYEFSETRK---- 283
            ||..:.:.|..:.....|..:|....|..::..|    |.:.|     ::..|:|..:.||
Human   388 PTVILRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYLTLWEEKQQRKKEKS 452

  Fly   284 --------------VLEEFFKANPED----EKRYTDYTTESGDDVASSQPQEYPATPMEQA---- 326
                          ::..|||...:.    :.|...:|.:||     |..:.||...:|:|
Human   453 GSPGEKGALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDSG-----SLAKTYPRLDIEKAGGVG 512

  Fly   327 ----YIGQRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLA----- 382
                ::..||.|  ..|......|.....||.|.|:...|    ::.: :|......|||
Human   513 PVQKFVTWRLRR--DQERGRALLSARSGSPSSQLPNVDEQ----VQAW-ESRRPLIQDLAQRLLT 570

  Fly   383 DTELEANLRRHSRNFTLSPETTDYDSNCGDLDS-------------LSNDIN---CPTDFGKLYT 431
            |.|:.| :.||...:.       ::....||..             |..||.   .|||.|: :.
Human   571 DDEVLA-VTRHCSRYV-------HEGGIEDLVRPLLAILDRPEKLLLLQDIRSVVAPTDLGR-FD 626

  Fly   432 SMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDAS 496
            ||.:|                 |..:..::.:|:.|.
Human   627 SMVML-----------------VELEAFEALKSRAVR---------------------------- 646

  Fly   497 QSALISDFASLPMPPAPPPS---SPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTE 558
                         |||..|:   :||:..:      :|.|||:       .|..|...:.|...|
Human   647 -------------PPALRPARQDTPPKRHL------ITPVPDS-------RGGFYLLPVNGFPEE 685

  Fly   559 KSAG------SGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPD 617
            :..|      ..|.|:|..:....|.:....:|:...:..:.|:.|.|.|.:|   ..|.|. |.
Human   686 EDNGELRERLGALKVSPSASAPRHPHKGIPPLQDVPVDAFTPLRIACTPPPQL---PPVAPR-PL 746

  Fly   618 SPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNG 682
            .|.|                       |.|:.|  .:.|..|.....::.:.:.:...:...|:.
Human   747 RPNW-----------------------LLTEPL--SREHPPQSQIRGRAQSRSRSRSRSRSRSSR 786

  Fly   683 HLNGTSDNNNPNPMNNSKP-----QTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQ 742
            ....:....:|:|:....|     :.:.....|..:...|...:..:....|.::.......|..
Human   787 GQGKSPGRRSPSPVPTPAPSMTNGRYHKPRKARPPLPRPLDGEAAKVGAKQGPSESGTEGTAKEA 851

  Fly   743 FTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMM 807
            ..|:|:|.:|::  :.:..|::...:..|.:|.||                     ||
Human   852 AMKNPSGELKTV--TLSKMKQSLGISISGGIESKV---------------------QP------- 886

  Fly   808 QAEEAVSRIKALAPEGESQPSTEVDLFIS------TEKIMVLNTDLKEIMMDHALRTI-----SY 861
                 :.:|:.:.|.|.:        |:|      .|.:.|...:|:::....|:.||     :.
Human   887 -----MVKIEKIFPGGAA--------FLSGALQAGFELVAVDGENLEQVTHQRAVDTIRRAYRNK 938

  Fly   862 IADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPL 910
            ..:..:|||.:..    |:....||.:|.|.|   .|:..:..|..:||
Human   939 AREPMELVVRVPG----PSPRPSPSDSSALTD---GGLPADHLPAHQPL 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	28/147 (19%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492	16/79 (20%)
		PDZ_signaling	209..289	CDD:238492	11/84 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		2/19 (11%)
		HN_PDZD7_like	554..630	CDD:259824	20/85 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864		15/113 (13%)
		PDZ_signaling	860..948	CDD:238492	21/130 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033		13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810