DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Grip1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	942	Identity:	184/942 - (19%)
Similarity:	307/942 - (32%)	Gaps:	323/942 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 QRLARIPKDEL-YMVHRSPTKKP-----------PSDQNPSTAYQ----EHNDIELYID------ 372
            |.|.|:.|||. |....|.||.|           |.:...||..:    |...:.|.:.
Mouse    68 QILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKD 132

  Fly   373 -----SNSRSSGDLADTE-------LEA----NLR--RHSRNFTLSPETTDYDSNCGDLDSLSND 419
                 ||.|..|..|.::       ::|    ||.  ||....:|.       .|.|:...|..:
Mouse   133 GKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLL-------KNVGERVVLEVE 190

  Fly   420 INCPTDFGKLYTSMPVLEDGLS---------------------SGHASDTENN---VSVVCDK-- 458
            ...|          ||...|.|                     .|.|.|..|.   |.:.|.:
Mouse   191 YELP----------PVSVQGSSVMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPG 245

  Fly   459 ---QQSSQSQPVHEHNGNGERLENDYNVM------SASLATLTTDASQSALISDFASLPMPPAPP 514
               .:....:|       |:||.:...:.      :.:::.|.....::.|:.::....|.....
Mouse   246 GPADREGTIKP-------GDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVAT 303

  Fly   515 PSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQ 579
            .|.|..:|:|                                  |:.|:.|||...|      |.
Mouse   304 ASGPLLVEVA----------------------------------KTPGASLGVALTT------SV 328

  Fly   580 AASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTD 644
            ..::....:.:|:||  ....:...|...|.:|..|          ||::.....|.|.:
Mouse   329 CCNKQVIVIDKIKSA--SIADRCGALHVGDHILSID----------GTSMEYCTLAEATQ----- 376

  Fly   645 LETDRLLGQQRHDEQDFFA---DQSLADNNANEGTDIASNG--HLN-GTSDNNNPNPMNNSKPQT 703
                            |.|   ||...:...:..|.:|..|  |:. ..||..:|         .
Mouse   377 ----------------FLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQHP---------W 416

  Fly   704 YSTATIRQGIGTSLTPNS--PDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKS 766
            .:.|:.:.|:.|:...|:  ||.|::.     :::.|:.|. ..||...:.|...::.|.....|
Mouse   417 DAWASNQCGVHTNHHHNTYHPDHCRVP-----ALTFPKALP-PNSPPAMVPSSSPTSMSAYSLSS 475

  Fly   767 RNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEV 831
            .|.           |.|.|:.|..|.      :.|...|.::.::..|.:        |..|:.|
Mouse   476 LNM-----------GTLPRSLYSTSP------RGTMMRRRLKKKDFKSSL--------SLASSTV 515

  Fly   832 DLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPT 896
            .|     ...|::|:..|:::     |...:...|   :.:....|...::..|.:.|.:
Mouse   516 GL-----AGQVVHTETTEVVL-----TADPVTGFG---IQLQGSVFATETLSSPPLISYI----- 562

  Fly   897 PGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKE 961
                |.:||.:.            |.|.:          ||.       ..:..|||..|....|
Mouse   563 ----EADSPAER------------CGVLQ----------IGD-------RVMAINGIPTEDSTFE 594

  Fly   962 MDYQEVLNSQ-------EIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLP--TVV 1017
            ...|.:.:|.       ||..|..|..........|.:||.....||:.|  |...|..|  .:|
Mouse   595 EANQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHSVELGITI--SSPSSRKPGDPLV 657

  Fly  1018 IANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVK 1082
            |:::.....|.|.|.|.:||:|:||:.:.|            .|...:.||:. :..|..:|::|
Mouse   658 ISDIKKGSVAHRTGTLELGDKLLAIDNIRL------------DNCSMEDAVQI-LQQCEDLVKLK 709

  Fly  1083 ILRPK----------ALF----------QLGFSVQNG-------VICSLLRGGIAER-GGVRVGH 1119
            |.:.:          |:.          .||.::...       :|.||.:||:||| |.:.:|.
Mouse   710 IRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGD 774

  Fly  1120 RIIEINNQSVVAVPHDTIVKLLSSSVGEILMK 1151
            ||:.||:.|:...|....:.||..:...:.:|
Mouse   775 RILAINSSSLKGKPLSEAIHLLQMAGETVTLK 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	29/178 (16%)
		PDZ_signaling	988..1065	CDD:238492	22/78 (28%)
		PDZ_signaling	1092..1151	CDD:238492	20/66 (30%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492	16/86 (19%)
		PDZ_signaling	209..292	CDD:238492	12/89 (13%)
		PDZ_signaling	307..390	CDD:238492	25/155 (16%)
		PDZ_signaling	526..614	CDD:238492	21/133 (16%)
		PDZ_signaling	627..711	CDD:238492	27/98 (28%)
		PDZ_signaling	727..808	CDD:238492	21/80 (26%)
		PDZ_signaling	1058..1138	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900