DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Pard3b

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	657	Identity:	122/657 - (18%)
Similarity:	216/657 - (32%)	Gaps:	214/657 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 SLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTD-PDSPVWVPRKGTTISTAQGAAAD 638
            ||..|..|.::||:.::......|:.....:...||..|.. .:||             .|..||
Mouse    81 SLRKQVTSPLEEAVLQVSFLHSLAEAVLMLIAVFDEQEPLQKTESP-------------GGNPAD 132

  Fly   639 EEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLN-GT------SDNNNPNPM 696
            .:.....||:              ....||......|..:.:...|. ||      |.:..|.|.
Mouse   133 RQSPDAFETE--------------VAAQLAAFKPVGGEIVVTPSALKLGTPLLVRRSSDPAPGPH 183

  Fly   697 NNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSD 761
            .:::|.|.|.:      |.||.|...|..|       ::.:.|.:...::...|:...||..:..
Mouse   184 ADAQPSTASLS------GQSLKPVVLDSTQ-------NVENKEAMNGEQAGLLSLHRPKDELSDM 235

  Fly   762 KKAKSRNKEG------------LLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVS 814
            .:|...:.||            .|..::|  |:..|.        :.|....|...:.|..|.:.
Mouse   236 TRAVEISGEGDPLGIHVVPFFSSLSGRIL--GLFIRG--------IEENSRCKQEGLFQENECIV 290

  Fly   815 RIKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVP 879
            :|            ..|:|.   :|......|    :...|:::.|.|     |.||:.:.|
Mouse   291 KI------------NNVELL---DKTFAQAQD----VFRQAMKSPSVI-----LHVLLPQNR--- 328

  Fly   880 NSVVDPSITSPL-------GDVPT---------PGI------------GEEESPPKEPLSKHNRT 916
             ...:.|:..||       |...|         ||:            |||.:.|::  ||..|.
Mouse   329 -EQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLTRASSPEGEEPASPQQ--SKSPRV 390

  Fly   917 PKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIF 981
            |::                              .....:.||:..|.                 |
Mouse   391 PRL------------------------------GRKPSSPSLSPLMG-----------------F 408

  Fly   982 AKKELQKEVVVPKAKG-EILGVVIVESGWGSMLP-TVVIANLMSSGAAARCGQLNIGDQLIAING 1044
            ..|:..|::.:...|| |.||..:|........| .:.:.|::..|||.:.|:|..||:::.:||
Mouse   409 GSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNG 473

  Fly  1045 MSLVGLPLSTCQSYIRNAKNQTAVKFTVV---------------PCPPV---------VEVKILR 1085
            ..:.|.......:.:|:.|....|...:.               .|..:         :|:. |.
Mouse   474 RDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIP-LN 537

  Fly  1086 PKALFQLGFSVQN----------GV-ICSLLRGGIAERGG-VRVGHRIIEINNQSVVAVPHDTIV 1138
            ......||.|::.          |: |.|::.||.|.:.| :|:..::|.:|.::::...:...:
Mouse   538 DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAM 602

  Fly  1139 KLLSSSV 1145
            :.|..|:
Mouse   603 ETLRRSM 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	34/206 (17%)
		PDZ_signaling	988..1065	CDD:238492	21/78 (27%)
		PDZ_signaling	1092..1151	CDD:238492	15/66 (23%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492	20/120 (17%)
		PDZ	415..504	CDD:214570	22/88 (25%)
		PDZ_signaling	536..624	CDD:238492	16/74 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900