DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Dlg5

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	828	Identity:	154/828 - (18%)
Similarity:	260/828 - (31%)	Gaps:	251/828 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 TKKPPSDQNPSTAYQEHND------IELYIDSNSRSSGDLADTELEANL--RRHSRNFTLSPE-- 402
            |.|.||.. |....|:.||      |:|.:.:..|:       ||...|  ..|...|...|.
Mouse   127 TGKAPSPP-PLLTEQQANDTVENLSIQLRLMTRERN-------ELRKRLAFATHGATFDKRPYHR 183

  Fly   403 -TTDYDS---NC----GDLDSLSN----------DINCPTDF-----GKLYTSMPVLEDGLSSGH 444
             ..||:.   .|    .||.||.|          ::...|||     .:|.:....|:|.:....
Mouse   184 LNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTQLKDDVDMLR 248

  Fly   445 ASD----TENNVSVVCDKQQS-------------------SQSQPVHEHNGNGERLENDYNVMSA 486
            ..:    .|.|:     .|||                   :|.|.|.:|||:.|.|...|:....
Mouse   249 RENGKLRRERNL-----LQQSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMD 308

  Fly   487 SLATLTTD-------ASQSALI--SDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDS 542
            .|..:..|       .|:...:  ||.:.|..      .......:...:|.:|...|....| .
Mouse   309 KLEVVKKDYDALRKRYSEKVAMHNSDLSRLEQ------LGEENQRLQKQTEMLTQQRDTAIQL-Q 366

  Fly   543 HYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKF 607
            |..|:........|.|        ::..||...........:|..:.|:||...:...:.||.|
Mouse   367 HQCALSLRRFETIHHE--------LSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYK- 422

  Fly   608 CDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLAD-NN 671
                                           ||.|......:|:..:|        ||.::: :.
Mouse   423 -------------------------------EERDAVYSEYKLIMSER--------DQVISELDK 448

  Fly   672 ANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTS----LTPNSPDICQIVGTT- 731
            .....::|.:...:.||:....:....:..|...|.|:..|....    |......:||.:...
Mouse   449 LQTEVELAESKLKSSTSEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEAL 513

  Fly   732 ----------DISISSPEKLQFTKSPTGSIKSLKDSANSDK-KAKSRNKEGLL---EPKVLIEGV 782
                      |.:....:|:...:.   ||::|.|:...:: :|.|...|.|.   :.:.....|
Mouse   514 QEADVAKCRRDWAFQERDKIVAERD---SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDV 575

  Fly   783 LFRARYLGS----TQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVL 843
            ....:.|.|    .|:.|  |..|..|..|.....|...|:..:.....:..|:....||.|
Mouse   576 SRELKELNSCVHREQMEC--QLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI--- 635

  Fly   844 NTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKE 908
              |||.:..|.|                                         .|:.|.
Mouse   636 --DLKALGFDMA-----------------------------------------EGVNEP------ 651

  Fly   909 PLSKHNRTPKMICHVFESDEAQFIAQ----SIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLN 969
                        |  |..|...|:.:    ||...........|:.|.::..:..|:...:.:||
Mouse   652 ------------C--FPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLN 702

  Fly   970 SQEIFGDELEIFAKKELQKEVVVP---------KAKGEILGVVIVESGWGSMLPTVVIANLMSSG 1025
            .:...  .:.:..:|.|..:||.|         .::.:..|:.: |:|       |..|.::...
Mouse   703 GEGAI--NMVVRRRKSLGGKVVTPLHINLSGQKGSRPQDSGISL-ENG-------VYAAAVVPGS 757

  Fly  1026 AAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVV 1073
            .||:.|.|.:||:::||||::|....|:.|:|.:|:.::...:....|
Mouse   758 PAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKV 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	30/186 (16%)
		PDZ_signaling	988..1065	CDD:238492	23/85 (27%)
		PDZ_signaling	1092..1151	CDD:238492
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141	24/91 (26%)
		Smc	<141..564	CDD:224117	89/492 (18%)
		PDZ_signaling	625..712	CDD:238492	22/154 (14%)
		PDZ_signaling	<741..800	CDD:238492	20/66 (30%)
		PDZ	1357..1439	CDD:214570
		dbPDZ_assoc	1437..1512	CDD:374667
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900