DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Pdzph1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	1139	Identity:	205/1139 - (17%)
Similarity:	357/1139 - (31%)	Gaps:	391/1139 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 EEERSGTLREKTPTFDYLYEFSETR-KVLEEFFKANPEDEKRYTDYTT-----------ESGDD- 309
            :::|.||              |:|. :|..:..|...||.|.:|..|.           |:||:
Mouse     2 QKKRMGT--------------SQTSGQVCPQNVKDLEEDIKGHTSETVFHQTRTLGKLKENGDEN 52

  Fly   310 -VASSQPQEYPATPMEQAYIGQRLARIPKDELYMVHRSPTK--KPPSDQNPSTAYQEHNDIELYI 371
             .||...::      ..:::.:...:.|.|.  .:|:|...  .||:   .|...:|...:.::.
Mouse    53 ITASINGKQ------NSSFLVKNEKQAPSDS--TIHKSMENGYTPPA---ISPQLEEVLPVAMFN 106

  Fly   372 DSNSRSSGDLADTELEANLRRHSRNFTLSPETTDY--DSNCGDLD---SLSNDINCPTDFGKL-- 429
            |......|.:...:....:.      .|.|....:  :..||..:   ..:..|.|.|....|
Mouse   107 DREKSLPGKITTEDFPNTVE------VLKPAKGKFIREVKCGAFNVHVETTKSIFCKTGAQNLTK 165

  Fly   430 ---------YTSMPVLEDGLSSGHASDTEN--------------------------NVSVV---- 455
                     |:...|.....|.||.|....                          |:|:|
Mouse   166 RRCPTCHQHYSVQQVWRGSKSRGHFSKHRTVLAEEFKRRVPSTYRRGVSRSEVPSVNISIVGKEI 230

  Fly   456 ---------------C--------------------DKQQSSQSQPVHEHNGNGERLENDYNVMS 485
                           |                    |:...|.|||...|..| :||||.:....
Mouse   231 MVEYISKKQNTFINICHPNSIGKLTKHRRGPLKHTTDEPCESASQPGINHPEN-QRLENQHQSSD 294

  Fly   486 A------SLATLTTDASQSALISDFASLPMPPAPP-------PSSPPQIEIADASESMTMVPD-- 535
            |      |:..:..:.|.:.::    ||..||...       ||:|...|..:::.|...|..
Mouse   295 AFHDAPCSVNAVQKENSDTIVV----SLSSPPRREKEKPNTLPSAPDDSEEGESATSPQKVLQIT 355

  Fly   536 ADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEI---RSALQR 597
            .|.||:.|.                         .||...||:.:.:....::..:   :.:|:.
Mouse   356 QDKPLEQHC-------------------------FTADSCLPTSSETLRTTSLNNVDLSKMSLED 395

  Fly   598 AKTQPEKLKFCDEVLPT-DPDSPVWVPRKGT--------TISTAQGAAADEEPDTDLETDRLLGQ 653
            ::...|:.|...:|... .|||.|.....||        :|...|.|:..|.......|.:|||.
Mouse   396 SRDVDEERKNSSDVRENITPDSQVQPCTAGTNGPLSAVNSIIPIQDASGSEFSPLSFLTLQLLGA 460

  Fly   654 QRHDEQDFFADQSLADNNANEGTD-IASNGHLNGTS-------DNNNPNPMNN--------SKP- 701
            :             |||....|.: :...||.:..|       ....|:|:.:        |:|
Mouse   461 K-------------ADNMGCRGEETLPGEGHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPV 512

  Fly   702 -QTYSTATIRQGIG---------------TSLTPNSPDICQIVGTTD-----ISISSPEKLQFTK 745
             .|.:|.:..|.||               .||..:|....|.:...|     ::|:|...| ..|
Mouse   513 ETTGNTFSFSQYIGVEREQEKVHYRLINKASLHNDSSSNIQPLERKDPQSPAVTIASCSIL-VPK 576

  Fly   746 SPT-GSIKSLKDSANSDKKAKSRNKEGL--LEPKVL------IEGVLFRARYLGST----QLVCE 797
            ||. |:|.|..:...::..|....:.||  :|..|:      :|..|....|..||    ..:..
Mouse   577 SPLHGNIHSSVEWNQTEDHANHAERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAI 641

  Fly   798 GQPTKSTRMMQ-----AEEAVSRIK--------ALAPEGESQPSTEVD-LFISTEKIMVLNTDLK 848
            ..|.:||..::     |.:|:..:|        .|..|.:::..:::| |..|:|...|.:|..|
Mouse   642 RNPRESTSYLENVGDDASQALPVVKNMCHRNFEDLTRENQNEICSQMDFLQNSSESTSVGHTTEK 706

  Fly   849 EIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKH 913
            ..::|..|.:                         |....|. .|..|.|:...:   :||....
Mouse   707 LFLIDKTLAS-------------------------DDDSNSN-RDHKTCGLNNFQ---QEPAECQ 742

  Fly   914 NRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDEL 978
            ..|.::.|.  ||...::..:             :..:.::   :......|:.|..|     .|
Mouse   743 RTTSRVYCE--ESGNQRYPTE-------------VSCHPVD---ILLSPQKQKALKDQ-----NL 784

  Fly   979 EIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGA--------AARCGQLNI 1035
            ||...::|.:|:.:...:.                         |.|:        |.|..|...
Mouse   785 EINNPRKLSQELALRGGRA-------------------------SDGSQEEAIEQWARRRQQFKD 824

  Fly  1036 GDQLIAINGMSLVG--------------------LPLSTCQSYIRNAKNQTAVKF---------- 1070
            |.:..:..|.|::.                    :.:.....|..|. :.||..|
Mouse   825 GKRCSSAGGSSVISNFTEGSITSDDVHSVDFGFRVDIEEKGFYTENF-HSTAWVFRGDDGNPEDS 888

  Fly  1071 ----TVVPCPPVVE---VKILRPKALFQLGFSVQNG---VICSLLRGGIAERGGVRVGHRIIEIN 1125
                :..|.|..|.   |::.:....:..||.:|..   |:..:.....||..|:::|..::.:|
Mouse   889 PRCLSKKPRPVAVRERTVRLFKGTGDYPWGFRIQFSKPIVVTEVDTNSAAEEAGLQIGDVVLSVN 953

  Fly  1126 NQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFR 1159
            ...|.:|.|...|.|....: :||...:.:.:.|
Mouse   954 GTEVTSVEHAEAVHLAKKGL-DILTMVVASDISR 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	34/202 (17%)
		PDZ_signaling	988..1065	CDD:238492	11/104 (11%)
		PDZ_signaling	1092..1151	CDD:238492	16/61 (26%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	17/78 (22%)
		PH-like	986..1093	CDD:302622	1/1 (100%)
		PH	993..1094	CDD:278594
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900