DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	1433	Identity:	273/1433 - (19%)
Similarity:	458/1433 - (31%)	Gaps:	435/1433 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSPDLNG 71
            |.|..||:|..|.........|  ..||:..:::...|....::...:|...|.:.|
Mouse  1514 SSSDPESLVEDPRAAARNNWPA--PPSHESSRKEGSSESEDEQIEICAPGGCPETPV-------- 1568

  Fly    72 ELSYVPLQGLSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQGLA 136
                       |:....|.:|                         |..|..|...|:  |.|.|
Mouse  1569 -----------PAQAPAQAAG-------------------------GAVPSVQQTVRE--PVGDA 1595

  Fly   137 SPGSPTDVGKADGQCLRDGEIVVFDDIDTN------WMN-KASSGQRPGSNEDVLKVT---KMIG 191
            ...:....| |...|: .|....|..:|.:      |.. :.|....||..|:.|.|:   .::|
Mouse  1596 CEKACFMTG-ASNTCI-PGSSQPFSFLDVSSLEHETWAGVQTSRSHMPGCAEETLAVSSTGSVVG 1658

  Fly   192 QLPIAEYEGSPRRFGSQPNTNTITMGGP---RKRP------------PGFPQRVSPTTSVANNAT 241
            .              |||:..|...|.|   .:.|            .|.|.:.:..:.|.::..
Mouse  1659 D--------------SQPSQTTRPCGNPPFVLRNPDMVNGLGQDLLDEGTPDKGADASHVMSSVY 1709

  Fly   242 AAAK---------------ASVGNLIDLVDHEEERSGTLREKTPTFDYLYEF----------SET 281
            |...               |..|||..|:...:..|     :.|...:..:.          |::
Mouse  1710 ALGAEGPKNGEAVLANLHIAKGGNLDGLLQKPKTTS-----RRPIMTWFKDINKDSQGAHLQSKS 1769

  Fly   282 RKVLEEFFKANPEDEKRYTDYTTESGDDVASSQP-----QE----YPATPMEQAYIGQRLARIPK 337
            .|........:|..:....:.:...|..|..|.|     ||    .|.:|:|.....|:....||
Mouse  1770 EKEQPSMLAMSPGSKGNTVNPSHRKGMAVPKSPPPRQKSQENKDLSPKSPVETLSNCQKPKGSPK 1834

  Fly   338 DELYMVH-----------RSPTKKPPSDQ-----NPSTAYQ------EHNDIELYIDSNSRSSGD 380
              |..::           .||.|...:|.     :|..|::      .|   .|:|.........
Mouse  1835 --LKRLNSKSKASPEAPVASPAKGGRTDHRKSLPSPQAAHKMLSKAVSH---RLHIADQEEPKNT 1894

  Fly   381 LADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHA 445
            ..||         |:.....||:....:..|.|.:.::|.:..|....|.:..|:.|.|
Mouse  1895 AGDT---------SKPPQCVPESKPPLAASGSLRTSASDTSIRTITSPLTSPKPLPEQG------ 1944

  Fly   446 SDTENN-----VSVVCDKQQSSQSQP---------VHEHNGNGERLENDYNVMSASLA------- 489
               .||     |.:..|....:.|:|         .|.::|:.....:..|:..|.:.
Mouse  1945 ---ANNRFHMAVYLESDTSCPATSRPPRYGPEGKVPHANSGSVSPSASRTNIALAGVRQSKQFTH 2006

  Fly   490 ----TLTTDASQSALISDFASLPMPPAPPPSSPPQIEIAD-ASESMTMVPDADNPLDSHYGAVYA 549
                .:.|:|:|...||:..:..| .:.|.....|::|.: :||.|......|.|..|.
Mouse  2007 SRVDLVLTEAAQPQGISEKGTEKM-ASDPLERTNQLKIIEISSERMPKNACGDKPPGSD------ 2064

  Fly   550 AALGGTHTEKSAGSGLGVTPVTAGGSL-------PSQAASEIQE-----AMKEIRSALQRAKTQP 602
             ..||..|:.:......|....:..|.       ||||:...||     :|..:.|:...|...|
Mouse  2065 -RKGGFLTQSNCQEKSSVRLRQSAESSPKQPHFPPSQASQGEQEMRWSYSMARLASSSPSAPQLP 2128

  Fly   603 EKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSL 667
            .|:....:...:...:.|.||:.|..:    |.|.:|.|         ....|...:.:......
Mouse  2129 SKMPDYSQGKSSQMPASVGVPKNGVPV----GLAGEEPP---------YFTPRPATRTYSMPAQF 2180

  Fly   668 ADNNANEGTDIASNGH---------LNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPD 723
            :.:...||....|..|         ::|:....:...:.|.: ..||   ::..:.|...|...|
Mouse  2181 SSHFGREGLSPPSPSHSPQDPQVTAMSGSLSEKSAKGVTNEQ-GVYS---VKPLLETLRNPPPVD 2241

  Fly   724 ICQIVGTTDISISSPEKLQFTK-----------------SPTGSIKSLKDSANSDKKAKSRNKEG 771
            :..:....:.|...|:||:.|:                 |....|||.::.||||:.|.......
Mouse  2242 VGDVSAVPEASGLIPDKLKVTRRHYYCEQSWPHESTSFFSVKQRIKSFENLANSDRPAAKSATSP 2306

  Fly   772 LL----EPKVLIEGVLFRARYLGSTQLVCEGQPTKST------RMMQAEEAVSRIKALAPEGESQ 826
            .|    :|.|       ..|..||   :..|:|:..|      .:....|..|...:|.|:....
Mouse  2307 FLSVSSKPPV-------NRRSSGS---ITSGRPSDGTARSLRRSLSSCSENQSEASSLLPQMTKS 2361

  Fly   827 PSTEVDLFISTEKIMVLNT-----DLKEIMMD----------------------HA--------- 855
            ||: |.|.:|.:.....|.     |.|:.::.                      ||
Mouse  2362 PSS-VTLTVSRQNPPETNNKGHSPDPKKSLVPVGIPISTGSPASPIKRNKSSVRHAQPSPVSRSK 2425

  Fly   856 ---LRTIS------------YIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESP 905
               ||.:|            |.|..| .|:...:....|........|||   ..:|..|..:..
Mouse  2426 LQELRALSMPDLDKLCSGEDYSASPG-AVLFRTQLEITPRRSQGSPATSP---ASSPARGHADVN 2486

  Fly   906 PKEPLS-----------KHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLA 959
            ....||           |.|.:|.:.....|..|: ..|...|:::.|...:.|.:.|
Mouse  2487 GSAFLSCPVNGGNRVYPKGNSSPTVPTGSREWGES-LRAMPSGKSWSVNLDQLLASVG------- 2543

  Fly   960 KEMDYQEVLNS-QEIFGDE---LEIFAKKELQKE-------VVVPKAKGEILGVVIVESGWGSML 1013
                ||:.|.: ..:.|.:   |.:..:.:.|.|       :|:.|.:|..||..:  :|...:.
Mouse  2544 ----YQQRLQAVLSLVGSKSPILPLIQEAKAQSENKEDICFIVLNKKEGSGLGFSV--AGGADVE 2602

  Fly  1014 P-TVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTV----- 1072
            | :|::..:.|.|.|::.|.::.||.|:::||.||.||..|.....:..|:....|...:
Mouse  2603 PESVLVHRVFSQGVASQEGTVSQGDFLLSVNGTSLAGLSHSEVTKVLHQAELHKHVLMIIKKGND 2667

  Fly  1073 -----------------------VPCPP----------VVEVKILRPKALFQLGFSVQNG----- 1099
                                   :|..|          .:.|::|:..|  .||.|:..|
Mouse  2668 QPRPSFRQEPPSANGKAPFPRRTLPLEPGAGRNGAAHDALCVEVLKTSA--GLGLSLDGGKSSIA 2730

  Fly  1100 -----VICSLLRGGIAERGG-VRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMF 1158
                 ||..:.:||.||:.| :..|..|:.||.:.:|.:.|.....         :||::|....
Mouse  2731 GDGPLVIKRVYQGGAAEQAGTIEAGDEILAINGKPLVGLVHFDAWN---------IMKSVPEGPV 2786

  Fly  1159 RLL 1161
            :|:
Mouse  2787 QLV 2789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	47/246 (19%)
		PDZ_signaling	988..1065	CDD:238492	24/84 (29%)
		PDZ_signaling	1092..1151	CDD:238492	17/69 (25%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021	11/49 (22%)
		PDZ_signaling	2581..2663	CDD:238492	24/83 (29%)
		PDZ	2709..2791	CDD:214570	24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900