DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and dlg5a

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	969	Identity:	175/969 - (18%)
Similarity:	315/969 - (32%)	Gaps:	279/969 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 LIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQP 315
            ||:|:    .:||:|.|: ..|:.....|.:.:.:|:..|..   ..:.:|:..|....:..:.|
Zfish    26 LIELL----SKSGSLSEQ-EAFELDQNCSSSAEKVEQLLKML---MNKQSDHFLELCVALEKTYP 82

  Fly   316 QEYPAT------PMEQAYIGQR---LARIPKD-----ELYMVHRSPTKKPPSDQNPSTAYQEHND 366
            ..|.|.      |.:. :.|..   |:.:|.|     .|..|....:..||:
Zfish    83 HLYSALFSNGGGPADH-HSGSTYSVLSTMPSDSESSSSLSSVGTKASSPPPA------------- 133

  Fly   367 IELYIDSNSRSSGDLADTEL---------EANLRRHSRNFTLSPETT------------DYD--- 407
                 .|::|.:.|..||.|         ...||:  |....||.||            ||:
Zfish   134 -----LSDTRPASDSLDTILFQLKQVTRERDELRK--RLALASPGTTFDDCRPNSKPGHDYERLK 191

  Fly   408 SNC----GDLDSLSND-----INC-----PTDF-----GKLYTSMPVLEDGLSSGHASDTE---- 449
            :.|    .||.||.|.     ..|     ..|:     .:|.:....|::.:......:|:
Zfish   192 TQCTKAMADLQSLQNQHTKTLKRCEEAVKEADYYHIQHSRLLSEQTQLKEEMEVLKRENTKLTRE 256

  Fly   450 -NNVSVVCDK-------------QQSSQSQPVHEHNGNGERL--------------ENDYNVM-- 484
             |::...|::             ....|.|.|...||:.|.|              :.:|:|:
Zfish   257 HNHLKQSCEELRRLHSEDQREVADMRLQQQQVIRENGSSEVLNKLYDTAMDKLEGVKKEYDVLSK 321

  Fly   485 --SASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAV 547
              |..:::..||.|:.                    .|:|    .|:..:....|..|.....|:
Zfish   322 RYSEKVSSHNTDLSRL--------------------EQVE----EENRRLQKQIDALLKQRDTAI 362

  Fly   548 YAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVL 612
                   .:.::.:.|......|....:..|....|:|..|:.::|.:.|.|....|
Zfish   363 -------QYQQQWSTSMRRFDSVQQELNKASAQNKELQREMERLQSEVTRYKNFQLK-------- 412

  Fly   613 PTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTD 677
                             :...|....||.|:.....||:..:|        ||.:.:.:..:...
Zfish   413 -----------------AVKDGEKYKEERDSVFNEYRLIMSER--------DQVIKEVDKLQTEL 452

  Fly   678 IASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTD-ISISSPEKL 741
            .|:...|..||...    |..|:    ....:||.:.:||......||:.....: ......:|.
Zfish   453 EAAEARLKNTSSER----MVASE----ELEALRQELNSSLVDRDRAICERNELLEKYCHEVKDKA 509

  Fly   742 QFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRM 806
            :..|..:.:.|.::........|:....|.:::...|:. ..::||....:..:...:..|...:
Zfish   510 EAQKELSQACKDIETVREERDVARKERTEAIIQRDQLLR-EYYQARQKQDSATLDMERANKEIDI 573

  Fly   807 MQAE-EAVSR-IKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLV 869
            ::.: ||:|: :|....|.|.........|...:||:.....::.:..:........::|:.|.:
Zfish   574 LRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSDLADAL 638

  Fly   870 VLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQ 934
            ..:...|...|.....             :.|.:...:..|.|..|..:::.|  .|.::.....
Zfish   639 RNLDDMRKQRNDAARE-------------LKELKEKMESQLDKEARFCQLMAH--SSHDSAIDTD 688

  Fly   935 SIGQAFQVAYMEF--------LKANGIENESLAKEMDYQEVLNSQEIFGD--------------- 976
            |:  .::...:||        |||.|         .|..|.:|...:.||
Zfish   689 SL--EWETEVVEFEKDRDDMDLKAMG---------FDIAEGVNDPYLPGDCGIFVSRVDKGSIAD 742

  Fly   977 -------------ELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPT------------- 1015
                         ::::..|...|....|....|.|..||......|..|.|
Zfish   743 GRLRVNDWLLKINDVDLTNKDRKQVIKAVLNGGGLINMVVRRRKSLGGRLVTSVHINLIGHKDAG 807

  Fly  1016 ------VVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAV 1068
                  |.:|.:.....|||.|.|.|||:||||||::|....||.|::.:|..::..|:
Zfish   808 IALEGGVFVAGIAPGSPAAREGSLTIGDRLIAINGIALDNKSLSECEALLRGGRDSLAL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	30/188 (16%)
		PDZ_signaling	988..1065	CDD:238492	29/95 (31%)
		PDZ_signaling	1092..1151	CDD:238492
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018	15/69 (22%)
		Takusan	128..211	CDD:282652	23/102 (23%)
		Taxilin	295..627	CDD:286771	63/404 (16%)
		RILP-like	338..460	CDD:304877	26/165 (16%)
		SH3BP5	444..648	CDD:283045	33/212 (16%)
		PDZ_signaling	696..783	CDD:238492	17/95 (18%)
		PDZ_signaling	793..866	CDD:238492	22/72 (31%)
		PDZ	1381..1463	CDD:214570
		dbPDZ_assoc	1461..1541	CDD:293216
		PDZ	1541..1623	CDD:214570
		SH3_DLG5	1639..1701	CDD:212794
		Guanylate_kin	1780..1949	CDD:279019
		NK	1794..1950	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900