DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and lnx2b

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	796	Identity:	166/796 - (20%)
Similarity:	269/796 - (33%)	Gaps:	242/796 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 DSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGD---LDSLSNDIN----CPTDFGKL 429
            ||:.....|..|.||..::       .|.|.....|:.||.   ...|||.::    ||.|..::
Zfish    30 DSHLFEYQDEVDDELVCHI-------CLQPLLQPMDTPCGHTYCFQCLSNFLHDQDFCPVDRQRI 87

  Fly   430 YTSMPVLEDGLSSGHASDTENNVSVVCD-------KQQSSQSQPVHEHN---------GNGERLE 478
                .:.:...||....:..:.::|:|.       ..|..:.|| |.||         ...||.:
Zfish    88 ----QLQQCRASSLLVRNLLDKLAVLCPFRSECELSMQRCELQP-HLHNRCPAFKRLREEAERKK 147

  Fly   479 N-DYNVMSAS-----LATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDAD 537
            . .:|.:..|     ||    ||..:..|...|.|..|..|...:|...|..|           |
Zfish   148 RPSWNELKGSKSDGDLA----DAKSAQTIGRTAQLSAPSEPGLVNPAFEEGED-----------D 197

  Fly   538 NPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQP 602
            .||..   ::.|.|.......:..|..||:..|  ||.........|||.:::...|      :.
Zfish   198 TPLRC---SLVAEATVVELFREDPGEDLGLRIV--GGKDTPLGNIVIQEIVRDSLVA------RD 251

  Fly   603 EKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSL 667
            .||...|.:|..:..|.       .:||.::..|...:|.:.|   ||...|   |:.|
Zfish   252 GKLAPGDHILEVNDVSL-------ASISHSRAIAVIRQPCSRL---RLTVMQ---EKGF------ 297

  Fly   668 ADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTP--NSPDICQIVGT 730
                                    .|.|.::::|              |.:|  .||...|..||
Zfish   298 ------------------------KPRPEHHTQP--------------SASPPTQSPSTNQNHGT 324

  Fly   731 T-DISISSPEK--------LQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVL-IEGVLFR 785
            . .:::...|:        ::.::.|...|..|.....:.|..|.||.:     ||| |.|
Zfish   325 VIQVTLVKHERSEALGIKLIRKSEEPGVFILDLLPGGLAAKDGKLRNND-----KVLGING---- 380

  Fly   786 ARYLGSTQLVCEGQPTKSTRMMQAEE-----AVSRIKALAP---EGESQPSTEVDL--------- 833
                   |.:..|.|..:.:::||.|     .|.|::.::.   ||:|:.:..|..
Zfish   381 -------QDLRHGTPESAAQIIQASEMRVNFVVMRLQDVSEEGGEGQSRGARRVPEPQYFRRHSE 438

  Fly   834 --------FISTEKIMVLNTDLKEIM-------MDHALRTISYIADIGDLVVLMARRRFVPNSVV 883
                    |.|.||.:.|..:.::.:       .|...|...||..:            .|...:
Zfish   439 YMKEPPGGFSSQEKTVTLKKEPRQSLGITIAGGRDCRSRLPVYITSV------------QPVGCL 491

  Fly   884 DPSITSPLGDV--PTPGI-------GEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQA 939
            ....|...|||  ...||       .|..:..|...::...|.::| ..|..||.|
Zfish   492 HRDGTVKTGDVLLSINGIDLTHLTYNEAVTVLKTQTAQSTVTLRVI-QTFADDEEQ--------- 546

  Fly   940 FQVAYMEFLKANGIENESLAKE-MDYQE-----VLNSQEIFGDELEIFAKKELQKEVVVPKAKGE 998
                          :.||.::| ||..|     .:|...::...|.:.:.....:::::.|...|
Zfish   547 --------------DGESGSREDMDTMEGPKDDDINWVPLWTRWLGLPSCIHWCRDIMLMKTNSE 597

  Fly   999 ILGVVIV---ESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIR 1060
            ..|..||   |...|..  ...|..::....|...|:|..||:::|:||::.||:..|:....::
Zfish   598 SWGFSIVGGYEESRGQQ--PFFIKTIVPGTPAYFDGRLKCGDEIVAVNGVTTVGMNNSSLIPMLK 660

  Fly  1061 NAKNQTAVKFTVVPCP 1076
            ..||:  |..|||..|
Zfish   661 LQKNK--VTLTVVSWP 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	41/220 (19%)
		PDZ_signaling	988..1065	CDD:238492	20/79 (25%)
		PDZ_signaling	1092..1151	CDD:238492
lnx2b	NP_998105.2	RING	46..82	CDD:214546	9/42 (21%)
		PDZ_signaling	210..291	CDD:238492	22/98 (22%)
		PDZ_signaling	325..406	CDD:238492	19/96 (20%)
		PDZ_signaling	451..537	CDD:238492	17/97 (18%)
		PDZ_signaling	587..671	CDD:238492	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900