DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and ush1c

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_009296312.1	Gene:	ush1c / 564412	ZFINID:	ZDB-GENE-060312-41	Length:	586	Species:	Danio rerio

Alignment Length:	679	Identity:	131/679 - (19%)
Similarity:	237/679 - (34%)	Gaps:	204/679 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 END--YNVM-----SASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPD 535
            |.|  |:|:     |..|..|..|.  ..:|::...||:..|..|..|.:.::    :...:.|.
Zfish    22 EKDYLYDVLRMYHQSMDLPVLVGDL--KLVINEPKRLPLFDAIRPLIPLKHQV----QYDQLTPK 80

  Fly   536 ADNPLDSHYGAVYAAALGGTHTE---------KSAGSGLGVTPVT---AGGSLPSQAASEIQE-- 586
            ....|..       ..|..||.|         ...||||.::.:.   ..|::..|...||..
Zfish    81 RSRKLKE-------VRLDRTHPEGLGLSVRGGLEFGSGLFISQIVKDGQAGNVGLQVGDEIVRIN 138

  Fly   587 -------AMKEIRSALQRAKTQPEKLKFCDEV-LPTDPDSPV-W------VPRKGTTISTAQGAA 636
                   ..:|:.:.::..||...|::....: :.:..|.|: |      |...|...::..|.|
Zfish   139 GYSISSCIHEEVINLIKTKKTVSLKVRHVGMIPVKSSSDEPLKWQFVDQFVSESGEKSNSIAGLA 203

  Fly   637 ADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNP-----M 696
            :             :|.....|:..|.  ||          :.:.|  .|.|.::.|..     :
Zfish   204 S-------------IGGNEIKEKKVFL--SL----------VGTKG--MGISISSGPTKKPGIYV 241

  Fly   697 NNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSP----------TGSI 751
            :|.||.:.| |.:...:|       ..|.::.|....::|..|.::..||.          .||.
Zfish   242 SNVKPGSLS-AEVGLQVG-------DQIVEVNGVEFTNLSHQEAVRVLKSSRSLTITVLTGAGSE 298

  Fly   752 KSLKDSANSDKKAKSR--NKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVS 814
            ..:.|......:|:..  .:|.:.:.||.:|          :.::|.|.|..:..|.|:
Zfish   299 LFMTDEERLAVEARHELDRQELMHQKKVALE----------TNKIVKEQQEKERQRKME------ 347

  Fly   815 RIKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVP 879
             |...|.|.|.:...|::...:.||     ...||...|...:.                    .
Zfish   348 -ISQKAAEEEERYRKEMERIEAAEK-----KHHKEWEDDWGSKE--------------------K 386

  Fly   880 NSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAY 944
            ...|.|: .||             |||  |.::...:||.     ::..|....:..|:.|| .|
Zfish   387 KKSVSPA-ASP-------------SPP--PPTRLAPSPKP-----KTSTADSYEEETGEGFQ-KY 429

  Fly   945 MEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIF-AKKELQKEVVVPKAKGEILGVVIVESG 1008
            ::              :.|...:..:::|.|.::.:. .|||.:.::.             :|.|
Zfish   430 VD--------------DFDPHSMFTAEQIAGRDVRLLRIKKEGKLDLA-------------IEGG 467

  Fly  1009 WGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA--VKFT 1071
            ..|.|..:|::::...|||.:.|.:..||:::|:||..|..:.|:..|:.:..|.|...  :...
Zfish   468 IDSPLGKIVVSSIYEGGAADKHGGVVSGDEIMAVNGKILTDVTLAEGQTSMAQAWNSGGDWIDLV 532

  Fly  1072 VVPCPP------VVEVKILRP---KALFQ 1091
            :...||      |.:...:||   |.:||
Zfish   533 IAVSPPKEYEDEVPKAASVRPTAKKTVFQ 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	33/178 (19%)
		PDZ_signaling	988..1065	CDD:238492	18/76 (24%)
		PDZ_signaling	1092..1151	CDD:238492	131/679 (19%)
ush1c	XP_009296312.1	harmonin_N	2..80	CDD:259819	14/63 (22%)
		PDZ_signaling	85..165	CDD:238492	17/86 (20%)
		PDZ_signaling	212..292	CDD:238492	20/101 (20%)
		RILP-like	317..>379	CDD:304877	18/83 (22%)
		PDZ_signaling	447..534	CDD:238492	22/99 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900