DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and lnx1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	958	Identity:	172/958 - (17%)
Similarity:	282/958 - (29%)	Gaps:	372/958 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 SPTKKPP-----------SDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTL 399
            :||..||           .::|....|:|..|.:|..                        :..|
Zfish    21 TPTAPPPDLCHICGQRHLQEENHEYTYKEDVDDDLMC------------------------HICL 61

  Fly   400 SPETTDYDSNCGDL---DSLSNDI----NCPTD-------------------FGKLYTSMP---- 434
            .|.....|:.||..   :.|:|.:    .||.|                   ..||..|.|
Zfish    62 QPLIRPLDTPCGHTYCQECLTNFLLESDFCPVDRTPLMLQKCRKSSLLVHKLLDKLMVSCPFADH 126

  Fly   435 ---VLEDGLSSGH---ASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTT 493
               |:..|...||   .....::..:..::::.||         .|:..::...:..|:|.....
Zfish   127 CTEVMPRGEMEGHIRCRCKGASHYGLSAERKRRSQ---------EGDCTDSTSELTLAALPGEGC 182

  Fly   494 DASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTE 558
            .:|..||:||     .|....|:..|.:|....|.|.|.:........|.|......:: .:.:.
Zfish   183 PSSAIALLSD-----EPGLVNPAYEPSVEDNSQSGSTTSLAARSGSRKSEYRNFDRTSV-RSRSF 241

  Fly   559 KSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLP---------- 613
            :.......|...|..|   :..|::..|....:|:|...|:.:...|.....::|
Zfish   242 RRLNRAFSVLRRTKSG---TAVANDTTEERDNLRNANIPAEGELFALPQLHHLIPDGEVTSIKIT 303

  Fly   614 -TDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTD 677
             .||..|:       .||...|   :|.|     ..|:|      .||.:          .||.
Zfish   304 RADPCEPL-------AISIVGG---NETP-----LVRIL------IQDIY----------REGV- 336

  Fly   678 IASNGHL---------NGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDI 733
            ||.:|.|         ||...:|        .|..|:.|.::|.            |.::..|.:
Zfish   337 IARDGRLLPGDMILKVNGIDISN--------VPHCYAVAALKQP------------CTLLRLTVL 381

  Fly   734 SISSPEKLQFTKSPTGS-----------------IKSLKDSANSDKKAKSRNKEGLLEPKVLIEG 781
            ............|||.:                 :|...|.....|..:..::.|:.... |:||
Zfish   382 REQRHRYRSHHHSPTEAFPAHTATIRDDSLHVVLVKRAPDEQLGIKLVRRPDEHGVFIFH-LLEG 445

  Fly   782 VLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVLN-T 845
                            |...:..|:                       .||     ::::.:| .
Zfish   446 ----------------GLAARDGRL-----------------------RVD-----DRVLAINGH 466

  Fly   846 DLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEE-----ESP 905
            ||:....:||...|....|         |..|         |.|....:|.|.|.:|     |.|
Zfish   467 DLRYGAPEHAALLIQASED---------RVHF---------IVSRQTHIPAPDILQEAPWNMEGP 513

  Fly   906 PKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNS 970
            |  |.|     |..|.|..                              .:|..|...|
Zfish   514 P--PYS-----PVDIEHTL------------------------------LDSCQKPACY------ 535

  Fly   971 QEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIV----ESGWGSMLPTVVIANLMSSGAAARCG 1031
                            :|.|.:.|...:.||:.:.    ..||.  || |.:.|:..:|...:.|
Zfish   536 ----------------EKTVTLLKEPHDSLGMTVAGGMSSRGWD--LP-VYVTNVDPNGVVGQEG 581

  Fly  1032 QLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKF--------TVVPCPPVV--------- 1079
            .:..||.|:.:||:.|.|:..|...:.::|..:...::.        :.:.|.|.:
Zfish   582 SIRKGDILLNVNGVDLTGVTRSEAVANLKNTSSPVVLQVLEMRPPNESSLDCMPPLHSPCALSPS 646

  Fly  1080 ---EVK----------------------------ILRPKALFQLGFSVQNG----------VICS 1103
               :||                            :||......||||:..|          .|.|
Zfish   647 SPGDVKLPPPNDDYAPLWVSWLQLPRHLYCCKDIVLRRSTSGSLGFSIVGGQEELNCNQSFFIRS 711

  Fly  1104 LLRGGIAERGG-VRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILM 1150
            ::.|..|...| :|.|..::|:|.:|...:.|..:|:||....|.|.:
Zfish   712 IVEGTPAYNDGRIRCGDILLEVNGKSTWGMTHTALVRLLKELRGRITL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	30/184 (16%)
		PDZ_signaling	988..1065	CDD:238492	22/80 (28%)
		PDZ_signaling	1092..1151	CDD:238492	21/70 (30%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546	8/59 (14%)
		PDZ_signaling	297..381	CDD:238492	27/135 (20%)
		PDZ_signaling	411..491	CDD:238492	20/142 (14%)
		PDZ_signaling	536..621	CDD:238492	22/87 (25%)
		DegQ	<548..621	CDD:223343	19/75 (25%)
		PDZ_signaling	678..762	CDD:238492	23/82 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900