DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and grip1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	966	Identity:	174/966 - (18%)
Similarity:	300/966 - (31%)	Gaps:	343/966 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 VHRSPTKKPPSDQNPSTAYQE-HNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDY 406
            :.||..:| .....|...|.| :.|:..|...:....|...         :|| |.:..|:
Zfish    11 IRRSRRRK-GKKYRPEEDYHEGYEDVYYYASEHLHHEGPYT---------KHS-NPSRPPD---- 60

  Fly   407 DSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDG------LSSGHASDTENNVS------VVCDKQ 459
                |.|......|  |.:|....|...:.::|      :|.|...|.:..||      :.....
Zfish    61 ----GALAIRRQSI--PDEFKGTSTVELIKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSD 119

  Fly   460 QSSQSQPVHEHNG-NGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSP---PQ 520
            |.:....:...|| |..:..:|      .:.:|..:..:..::.  ....:||.....|.   ..
Zfish   120 QLNVGDYIKSVNGINLTKFRHD------EIISLLKNVGERVVLE--VEYELPPVSVQGSGVMFKN 176

  Fly   521 IEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQ 585
            :|:....|..|            :|.|..   ||.|.:::....:.:|.:..||  |:.....|:
Zfish   177 VEVTLHKEGNT------------FGFVIR---GGAHEDRNKSRPVTITTIRPGG--PADREGTIK 224

  Fly   586 -------------------EAMKEIRSALQR--------------------------AKTQPEKL 605
                               |||..::...|.                          ||:....|
Zfish   225 PGDRLLSIDGIRLHGASHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKSMGSSL 289

  Fly   606 -------KFCD-EVLPTDPDSPVWVPRK------GTTISTAQGAAADEEPDTDLETDRLLGQ-QR 655
                   .:|: :|:..|...|..:..:      |..|.:..|.:.  |..|..|..:||.. ..
Zfish   290 GLALSTSMYCNKQVIIIDKVKPASIADRCGALHAGDHILSVDGTSM--EYCTLAEATQLLASASE 352

  Fly   656 HDEQDFFADQSLADNNANEGTDIASNG--HL------------NGTSDNNNPNPM--------NN 698
            |.:.:..         .:..|.:|..|  |:            :||::|:|..|.        :.
Zfish   353 HVKMEIL---------PHHQTRLALKGPEHVKVQRSTRPLPWESGTNNNSNFLPYQHYNTYHPDQ 408

  Fly   699 SKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKK 763
            |..|...|:.....:|:|.:|.|.....:   :.:::::..:..:..||.|::          .:
Zfish   409 SHSQAKKTSPSNPPLGSSFSPTSMSAYSL---SSLNMNTLPRTMYPTSPRGTM----------MR 460

  Fly   764 AKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPS 828
            .|.:.|:                 |..|..|                  .|....||.:.....:
Zfish   461 RKLKKKD-----------------YKSSMSL------------------ASSTVGLAGQVVHTET 490

  Fly   829 TEVDLFISTEKIMVLNTDLK-EIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLG 892
            |||.|.  ::.||.....|: .:.....|.:...||                  .:||
Zfish   491 TEVTLI--SDSIMGFGIQLQGGVFATETLSSPPLIA------------------YIDP------- 528

  Fly   893 DVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENES 957
                      :||.:.            |.:.:          ||.       ..|..|||..|.
Zfish   529 ----------DSPAER------------CGILQ----------IGD-------RILSINGIPTED 554

  Fly   958 LAKEMDYQEVLNSQ-------EIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLP- 1014
            ...|...|.:.:|.       ||..|..|..........|.:||..|..||:.|  |...|..|
Zfish   555 STLEETNQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKPGVELGITI--SSPSSRKPG 617

  Fly  1015 -TVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPV 1078
             .::|:::.....|.|.|.|.:||:|:||:.:.|            .|...:.||:. :..|..:
Zfish   618 DALIISDIKKGSVAHRTGTLELGDKLLAIDNIRL------------DNCSMEDAVQI-LQQCEDL 669

  Fly  1079 VEVKI---------LRPKALFQ-------------------------------LGFSVQNG---- 1099
            |::||         ||..::.:                               ||.::...
Zfish   670 VKLKIRKDEDNSGVLRAGSVDRNARVLLACVADEQETSGAIIYTVELKRYGGPLGITISGTEEPF 734

  Fly  1100 ---VICSLLRGGIAER-GGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMK 1151
               :|.||.:||:||| |.:.:|.||:.||:.|:...|....:.||..:...:.:|
Zfish   735 DPIIISSLTKGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGESVTLK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	26/179 (15%)
		PDZ_signaling	988..1065	CDD:238492	22/78 (28%)
		PDZ_signaling	1092..1151	CDD:238492	20/66 (30%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	13/87 (15%)
		PDZ_signaling	178..261	CDD:238492	17/99 (17%)
		PDZ_signaling	276..359	CDD:238492	16/84 (19%)
		PDZ_signaling	490..578	CDD:238492	26/153 (17%)
		PDZ_signaling	591..675	CDD:238492	27/98 (28%)
		PDZ_signaling	711..792	CDD:238492	21/80 (26%)
		PDZ_signaling	1053..1133	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900