DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and Grip

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	1347	Identity:	256/1347 - (19%)
Similarity:	407/1347 - (30%)	Gaps:	532/1347 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GQQAQQQQSHQHQQQQQQQERYVWEMRTRSPN---VTPASTVLNSPDLNGELSYVPLQ----GLS 82
            |:.|..:|..|.||||||      |....|.|   ..|..|.| :|.|:.:.:..|.|    ||:
  Fly    16 GKSAALKQDQQQQQQQQQ------ESHNNSFNGHHHPPTDTAL-APMLSVDRAMSPAQSEDSGLA 73

  Fly    83 PSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQGLASP---GSPTDV 144
            |..|....:.:...||             ||.       ...|..|:    .|:.|   ||...|
  Fly    74 PERGTTYATITLPRNA-------------LHL-------AITFAERN----DLSYPPVVGSLNPV 114

  Fly   145 GKADGQCLRDGEIVVFDDIDT------NWMNKASSGQRPGS------------------NEDVLK 185
            |.|.........:...|.|.|      ..||...:|   ||                  :::.|.
  Fly   115 GHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAG---GSDACPAIVEIEYSLPECTVSQNSLC 176

  Fly   186 VTKMIGQLPIAEYEGSPRRFGSQPNTNTITMGGPRKRP-------PGFP----QRVSPTTSVANN 239
            ||..:.|:.:....|.   .|       :|:.|....|       |..|    .|:.|
  Fly   177 VTSKLAQITVERESGC---LG-------LTLRGGADYPLIVTHVRPHGPVYKTGRIKP------- 224

  Fly   240 ATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTT 304
                     |:.:..||:......||.|                 .::..|.... ...||:.|.
  Fly   225 ---------GDRLLRVDNVSLIGKTLAE-----------------AQQIIKCGGH-VSGYTNLTI 262

  Fly   305 ESGDDVASSQPQEYPATPMEQAYIGQRLARIPK---DELYMVHRSPTKKPPSDQNPSTAYQEHND 366
            |.  ||:..|..|:...|:        |..|.:   |:|.:|..:.|...|:..:.|:.......
  Fly   263 EY--DVSVVQSVEFSMGPL--------LIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEK 317

  Fly   367 IELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSND---INCPTDFGK 428
            ||       .|:|....:.|.|::.......::..:....|....:..:.|.|   ....|..|:
  Fly   318 IE-------ESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGR 375

  Fly   429 LYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTT 493
            .||.|.::     ..||.....:.::...|                      |:..:......:|
  Fly   376 GYTQMQIM-----PAHALARRGHTTLGSPK----------------------YSFSTLESRKSST 413

  Fly   494 DASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAA-ALGGTHT 557
            ...|....:..:|||:                           :||.....|:...: ..||.|.
  Fly   414 AGRQRQRFARKSSLPL---------------------------ENPACGTPGSTGGSMGTGGIHG 451

  Fly   558 EKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDE----VLPTDPDS 618
            ..|.|.|||                            |.||::.|..|. |..    :|
  Fly   452 SSSLGMGLG----------------------------LCRAESFPVLLD-CSHGAGIIL------ 481

  Fly   619 PVWVPRKGTTISTAQG----AAADEEPDTDLET-------DRLLGQQRHDEQDFFADQSLADNNA 672
                   ..|:|.:.|    |.|...||:..:.       ||::...:....|..|.:.|.:..:
  Fly   482 -------SETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGS 539

  Fly   673 NEGTDIASNGHLNGTSDNNNPNPMNNSKPQ-------TYSTATIRQ---GIGTSLTPNSPDICQI 727
            :.      ||..|||..|.....:....|.       .:|...:|.   |:|.|::.:|.....|
  Fly   540 SR------NGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVI 598

  Fly   728 VGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGST 792
               :|:.:.||      ...:||::|                                    |..
  Fly   599 ---SDVKMGSP------AHRSGSLRS------------------------------------GDI 618

  Fly   793 QLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQ-PS-TEVDLFISTEKIMVL------------ 843
            .|..:..|.:...:    :|:     |..||.|| || :..|....|.|.:||
  Fly   619 LLAVDQHPVQHFNV----DAL-----LKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYS 674

  Fly   844 NTDLKEIMM----------DHALRTISYI--ADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPT 896
            |.....|.:          ||.|.:.:|:  ....|.|.|.:|                   .|.
  Fly   675 NCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSR-------------------TPQ 720

  Fly   897 PGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSI-----------GQAFQVAYMEFLKA 950
            |              .:.|.|.|       |:|..  ||:           .||          |
  Fly   721 P--------------DYFRVPSM-------DDASL--QSVQLRSGSGSNGGNQA----------A 752

  Fly   951 N----GIEN---------ESLAKEMDYQEVLNSQEIFGDELEIFAKKE-------LQKEV----- 990
            |    |:.:         :||..|:..:|....|...|.||..:|..:       ::.:|
  Fly   753 NSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAA 817

  Fly   991 -----------------VVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQ 1038
                             |..:.||.:||:.:  :|...:..::.|:.|:..|.|.:.||:::|||
  Fly   818 SSSSKSSGSSLHQIIFTVRLEPKGGLLGITL--AGSEDITKSITISGLVEGGIAHKNGQIHVGDQ 880

  Fly  1039 LIAINGMSLVGLPLSTCQSYIRNAKN-------------------QTAVKFTVV------PC--- 1075
            |:||:..|:.|:|||...|.::|..:                   ||...:..|      |.
  Fly   881 LLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANT 945

  Fly  1076 -------------------------PPVVEVKILRPKALFQLGFSV-----QNGVICSLLR-GGI 1109
                                     |.|..|.:.:.|.....||||     :.||..:.:| ||.
  Fly   946 EASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGP 1010

  Fly  1110 AERGG-VRVGHRIIEINNQS-----------VVAVPHDTIVKLLSSS 1144
            |:..| ::...||:::|...           ::|...|.|..::..|
  Fly  1011 ADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	40/219 (18%)
		PDZ_signaling	988..1065	CDD:238492	26/117 (22%)
		PDZ_signaling	1092..1151	CDD:238492	18/71 (25%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	18/88 (20%)
		PDZ_signaling	183..254	CDD:238492	17/114 (15%)
		PDZ_signaling	278..375	CDD:238492	19/111 (17%)
		PDZ	496..>521	CDD:294084	5/24 (21%)
		PDZ_signaling	571..658	CDD:238492	26/140 (19%)
		PDZ_signaling	832..913	CDD:238492	25/82 (30%)
		PDZ_signaling	973..1055	CDD:238492	20/81 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900