DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and si:ch73-40i7.5

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_003199465.1	Gene:	si:ch73-40i7.5 / 449850	ZFINID:	ZDB-GENE-041008-110	Length:	742	Species:	Danio rerio

Alignment Length:	831	Identity:	300/831 - (36%)
Similarity:	432/831 - (51%)	Gaps:	143/831 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 SNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSN-----CGDLDSLSNDINCP--------- 423
            |||::...:.|..|..|:..:|.|.   ||.|::..|     ..||||. |.|..|
Zfish    22 SNSQAEASVHDAHLTPNVCGYSTNV---PEFTNHRENLQSPELEDLDSY-NLIEPPPLDWRSDSS 82

  Fly   424 TDFGKLYTSMPVLEDGLSSGHAS-DTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSAS 487
            :|.|.: ..:.:...|....|.| :||.|..|:                    ..|.|:.....|
Zfish    83 SDAGSV-AELEICSVGDFEAHESFNTELNEDVL--------------------SAEFDHGAQHLS 126

  Fly   488 LATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAAL 552
            .|   .|.::..|:.:...:          .|:|.:..:.         |.|.::|..  ||.
Zfish   127 EA---PDKTEDLLVQEMCEI----------RPEISVCQSQ---------DAPQETHKS--YAG-- 165

  Fly   553 GGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEI-RSALQRAKTQPEKLKFCDEVLP-TD 615
               ..::|..:             |.....:|:|...:| .|.:|...||....|      | |.
Zfish   166 ---DRDRSCLN-------------PEMKIGKIREKENDIDHSHIQSLLTQLHLFK------PSTS 208

  Fly   616 PDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIAS 680
            .|:.........|:.|...:.|....:.:|.......   |.::|  |.::|..::..: .|:..
Zfish   209 FDNAAAFTLDHETLHTTAESTASSSQELELSAQSACA---HSDRD--APEALLFSHEYQ-KDLLQ 267

  Fly   681 NGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQ--F 743
                  ..:...|..:..: |:...|..:.....:||...|.|..:::..:....:..:.||  |
Zfish   268 ------LLEEPEPEELRTA-PEFVHTRLVTPEHQSSLRRQSSDADEVISMSQSQDAWHKHLQDEF 325

  Fly   744 TKS----------PTGSIKSLKDSANSDKKAKS----RNKEGLLEPKVLIEGVLFRARYLGSTQL 794
            ..|          ..|...:...|.|:|..|::    :|..|..:|:.|::||:|.|:|||||||
Zfish   326 LVSGVAEDDQWMQSEGLSANQSVSPNNDLDAETQPPYKNVPGPCDPEDLLDGVIFGAKYLGSTQL 390

  Fly   795 VCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTI 859
            ..|..|:.:.||.||:|||.|||  ||||||||.|||||||||::|.||:||.:|.||||:|:.|
Zfish   391 QSEKNPSTNARMAQAQEAVDRIK--APEGESQPMTEVDLFISTQRIKVLSTDTQEAMMDHSLQMI 453

  Fly   860 SYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVF 924
            |||||||:::||||||:             |.|...........:|||:..        ||||||
Zfish   454 SYIADIGNILVLMARRK-------------PAGRKSADSTDSSAAPPKKCW--------MICHVF 497

  Fly   925 ESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKE 989
            .|::||.|||:|||||.|||.:||..|||:...| |..:|.:.|.:||::..:|..|::.|..:|
Zfish   498 SSEDAQIIAQAIGQAFGVAYQQFLYTNGIKACDL-KPGEYSDYLGTQELYNGDLVHFSRSENIRE 561

  Fly   990 VVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLST 1054
            |.:.|..|||||:.||||||||:|||||:|||:..|.|.|.|:|:|||:::::||.||||||::|
Zfish   562 VCITKKAGEILGLAIVESGWGSILPTVVVANLLHGGPAERSGELSIGDRIMSVNGTSLVGLPIAT 626

  Fly  1055 CQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGH 1119
            |||.||:.||.:.:|.::|.||||....|.||...:||||||::|:||||:|||||||||:||||
Zfish   627 CQSIIRDLKNLSMIKLSIVHCPPVTMAIIKRPDPKYQLGFSVEDGIICSLMRGGIAERGGIRVGH 691

  Fly  1120 RIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            ||||||.|||||.||:.|:.:||::||||.:||||||.:|||||.:.|:::
Zfish   692 RIIEINGQSVVATPHEKIINILSNAVGEIHLKTMPTSTYRLLTGLDQPVFL 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	96/178 (54%)
		PDZ_signaling	988..1065	CDD:238492	47/76 (62%)
		PDZ_signaling	1092..1151	CDD:238492	43/58 (74%)
si:ch73-40i7.5	XP_003199465.1	PTB_X11	371..527	CDD:269919	96/178 (54%)
		PDZ_signaling	559..636	CDD:238492	46/76 (61%)
		PDZ_signaling	649..723	CDD:238492	49/73 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6013
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm6563
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.900