DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and CG15803

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	806	Identity:	156/806 - (19%)
Similarity:	259/806 - (32%)	Gaps:	291/806 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 SALISDFASLPMPP---------------------------------APPPSSPPQIEIADASES 529
            |.|..|.|..|:||                                 :|||.  |.:::......
  Fly   196 SELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPR--PALQMLPLETQ 258

  Fly   530 MTMVPDADNPLDSHYGAVYAAAL--------GGTHTEKSAGS----------------------G 564
            ...|.|.:.    |...|.|.:.        ||:.:...:||                      |
  Fly   259 WRCVQDQNR----HIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYG 319

  Fly   565 LGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPE-KLKFCDEVLPTDPDSPVWVPRKGTT 628
            ||:|  .||.....:..|.|     .::|.::.:..:.. :::..|.::..|..|     ..|.|
  Fly   320 LGIT--VAGYVCEEEDLSGI-----FVKSIIEGSAAETSGQIQINDRIVAVDGRS-----LSGVT 372

  Fly   629 ISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNP 693
            ...|.....:.:....|..:|.|..::::.......:.       :||...|.  |:.:.|.:..
  Fly   373 NHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEI-------KGTSAPSG--LDRSQDKDQD 428

  Fly   694 NPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTD-------ISISSPEKLQFTKSPTGSI 751
            .....|.|.:.|.||:     :.|.|.|.|...|....|       :.||..|. :|.:.|:
  Fly   429 QESQLSMPGSPSIATL-----SWLPPKSLDADSIATEGDEAVDAEYVGISGAED-EFIELPS--- 484

  Fly   752 KSLKDSANSDKK---AKSRNKEGLLE---PKVLIEGVLFRARYL-------GSTQLVCEGQPTKS 803
               :|:..|:..   .:|.:..||.:   |::.....|...|.|       ..|...| .:|...
  Fly   485 ---RDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQC-AEPETE 545

  Fly   804 TRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDL 868
            |             |.|.:| |:|.||                              .:.|:||
  Fly   546 T-------------AQARKG-SKPETE------------------------------RVKDLGD- 565

  Fly   869 VVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPK--EPLSKHNRTPKMICHVFESDEAQF 931
                .:....|:..:||      |.:|||   ..|:|.|  .|.:...|
  Fly   566 ----TKTDTDPDPDLDP------GQMPTP---TNEAPVKAASPTAASLR---------------- 601

  Fly   932 IA-QSIGQAFQVA-------------YMEFLKANG-IENESLAKEMDYQEVLNSQEIFG-DELEI 980
            :| :|:|.:.:..             |:..:.|:| :..:.:.:..|....:|..::.| ..:|:
  Fly   602 VAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEV 666

  Fly   981 F-AKKELQKEVVVPKAKGEILGVVIVES------GWGSMLP--------------------TVVI 1018
            . ..|||...|.:..|:|..:..||..|      ...|:||                    |...
  Fly   667 VKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSST 731

  Fly  1019 ANLMSSGAAA--RCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEV 1081
            |.|..:||||  ..|....|.:..::..:|  ||.|.:|:                     |..|
  Fly   732 ATLTDAGAAAGGSGGTAGGGARSKSLENVS--GLALWSCE---------------------VTAV 773

  Fly  1082 KILRPKALFQLGFSV--------QNG---VICSLLRGGIAE-RGGVRVGHRIIEINNQSVVAVPH 1134
            .|.:.:..|  |||:        ..|   ||..|:|||.|| ...:..|.|::.:.::.:..:..
  Fly   774 DIEKTEQGF--GFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLEL 836

  Fly  1135 DTIVKLLSSSVGEILMKTMPTSMFRL 1160
            |..|.:|         |.||..:.||
  Fly   837 DEAVSIL---------KAMPPGLTRL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	36/202 (18%)
		PDZ_signaling	988..1065	CDD:238492	23/104 (22%)
		PDZ_signaling	1092..1151	CDD:238492	17/70 (24%)
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	16/97 (16%)
		PDZ_signaling	605..680	CDD:238492	13/74 (18%)
		PDZ	773..858	CDD:214570	25/92 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900