DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and bbg

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster

Alignment Length:	1314	Identity:	257/1314 - (19%)
Similarity:	447/1314 - (34%)	Gaps:	374/1314 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QQQQSHQHQQQQQQQERYVWEMRTRS----------------PNVTPAS---TVLNSPDLNGELS 74
            |::.|.:..|..:..||.:..:..|.                |||.|.|   ||..:|.:  |:.
  Fly  1372 QRRGSLETAQPPKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNSKQATVETTPVV--EMP 1434

  Fly    75 YVPLQGLSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQ----IRLGRSPGSQFETRDVLPQGL 135
            ...||              :.|:...|.|.   :...|||    :..|.|..|  .|..:....|
  Fly  1435 PDELQ--------------FESHQLPDDGE---KEKDLHQESNDLLSGSSSSS--VTTPITTPIL 1480

  Fly   136 ASPGSPTD-----VGKADGQCLRDGEIVVFDDID-----TNWMNKASSGQRPGSNEDVLKVTKMI 190
            .|..|..|     :...:|..:...:....||||     .:.|:..:.|     .:||..|.::.
  Fly  1481 VSATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAAYDDGMHLEAEG-----TKDVRPVQEVT 1540

  Fly   191 GQLPIAEYEGSPRRFGSQPN--TNTITMGGPRKRPPGFPQRVSPTTSVANNATAAA--KASVGNL 251
            ......|:|..   .|:..|  :|..::.| .......|.....::|:...:|.||  |.:...:
  Fly  1541 TLTLDREHESD---LGTLSNHHSNISSISG-INASSNIPAATLISSSIKKTSTEAATTKPAAPQI 1601

  Fly   252 IDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQP- 315
            ...::.....:||....|....:|::.:.|:::|.:             ||.:.:.....|..|
  Fly  1602 PGKMELLSSNTGTTTTTTTATHHLHQATTTKQLLVQ-------------DYLSYASPPTYSRLPP 1653

  Fly   316 --QEYPATPMEQAYIGQRLARIPKDELYMVHRS----------PTKKPPSDQNPSTAYQEHNDIE 368
              .|:|....|...:.....::..:..|.:.:.          |...||:.. |...|::    :
  Fly  1654 DGHEFPPNFSEPLIMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPATV-PRKVYRQ----D 1713

  Fly   369 LYIDSNSRSSGDLADTELEANLRRHSRNFTLSPE-TTDYDSNCGDLDSLSNDI-NCPTDFGKLYT 431
            |.|                        |...:|. |.||..      |||... ..|:|:.|...
  Fly  1714 LVI------------------------NVEPAPSLTRDYQR------SLSGGTPRKPSDWRKDEK 1748

  Fly   432 SMPVLEDGL---SSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTT 493
            |...:.|.:   ||.:..|.............|...:|:   |.:.|.|.:  :..|:|..:|.|
  Fly  1749 SEKSVRDKIAMFSSNNELDAIPPAPATAPISSSFTRKPL---NRSSENLLD--SCSSSSAPSLKT 1808

  Fly   494 DASQSALISDFASLPMPPAPPPSSPPQIEIADASESM---TMVPD-ADNPLDSHYGAVYAAALGG 554
            .|.....::|.    ..........||:.:||:..|:   |..|. |..|..||         ||
  Fly  1809 RAMSVENLNDV----QRQYQLAKQLPQLHVADSMYSLNTATPTPSYASLPRRSH---------GG 1860

  Fly   555 THTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQ--RAKTQPEKLKFCDEVLPTDPD 617
            ::   |:|....::....||...::.|: |...:::.|.:|.  |....||:.:..:.:|    |
  Fly  1861 SY---SSGVERRISFSGEGGDAANRKAA-ITNILEQRRRSLSKLRGLVIPERPQLLEPIL----D 1917

  Fly   618 SPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNG 682
            .|        .|.:...||:.|:     .||..||:         :.:|..:.|...|...|:|.
  Fly  1918 LP--------EIKSQVKAASGED-----STDSGLGE---------SHRSTVNRNCQLGAGGAANN 1960

  Fly   683 HLNGTSDNNNPNPMNN------SKPQTYSTATIRQGIGTSLTPNSP----------------DIC 725
            : ....:.|...|:..      :||..           |||||..|                |..
  Fly  1961 Y-RSILNTNQRRPLEQQLSQPPAKPPR-----------TSLTPLQPRSMMIPPPPPPLDQESDTD 2013

  Fly   726 QIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLG 790
            .:...|....:.|||...|::.:....:...|:|:.......:           .|.......||
  Fly  2014 SVFSHTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSS-----------AGSQASCSSLG 2067

  Fly   791 STQLVCEGQPTKSTRMMQAE----EAV---SRIKALAP----------EGESQPSTEVDLF---- 834
            ||..|     ..:.|:::::    |||   ||...||.          :.|...||:.:..
  Fly  2068 STPAV-----DLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLAN 2127

  Fly   835 -----ISTEKIMVLNTDL-KEIMMDHALRTISYI---ADIGDLVVLMARRRFVPNSV-------- 882
                 ||:.|:......| |::::|..:...:|:   :|..|    .:||...|..:
  Fly  2128 RRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDD----SSRRSDTPAKISAMFIDEE 2188

  Fly   883 -------------------VDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFE-SD 927
                               |.|.:...|  :|        |..:|||.:  :|...:...|| |.
  Fly  2189 RKASFKGDPNQQAKVKVEQVKPMVLPML--LP--------SAKREPLKQ--QTTAELREKFERSA 2241

  Fly   928 EAQFIAQS----IGQAFQVAYME-FLKANGIENESLAKEMDYQEVLNSQEI---------FGDEL 978
            .||...|:    |.:..|..:.| |...:.:.:.|.......|.|..:||.         .|...
  Fly  2242 AAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQ 2306

  Fly   979 EIFAKKELQK--EVVVPKAKGEILGVVIV-----ESGWGSML--------PTVVIANLMSSGAAA 1028
            .:...:::|:  |...|..|.....::::     ||..|..|        ..:.|..::|:..||
  Fly  2307 SLITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAA 2371

  Fly  1029 RCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLG 1093
            :.|:|..||:::|:||||:.||            .::.::.....|.|.||.| :.|.::|....
  Fly  2372 KDGRLKKGDRILAVNGMSMRGL------------THRESISVLKTPRPEVVLV-VTRSESLVVKA 2423

  Fly  1094 FSVQNGVICSLLRGGIAERGGVRVGHRIIEIN-----NQSVVAVPHDTIVKLLSSSVGEILMKTM 1153
            .:.:...:.||          ..:..:..|::     |....:...|..:.|:|:..||..:.|.
  Fly  2424 LTKKRSSLGSL----------SSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATT 2478

  Fly  1154 PTSMFRLLTGQETP 1167
            |:      ||..:|
  Fly  2479 PS------TGSVSP 2486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	48/241 (20%)
		PDZ_signaling	988..1065	CDD:238492	22/91 (24%)
		PDZ_signaling	1092..1151	CDD:238492	9/63 (14%)
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	24/94 (26%)
		PDZ_signaling	2553..2634	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900