DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and dysc

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1224	Identity:	239/1224 - (19%)
Similarity:	363/1224 - (29%)	Gaps:	461/1224 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 WEMRTRSPNVTPASTVLNSPDLNGELSYVPLQGLSPSGGGVQGSGSY--GSNAGRDSGSYYYQRP 110
            |..|....|.|.|:..          |:    ||.||.||.|.|.|.  |.:||. ||
  Fly    35 WSARPYGYNATAAAAA----------SF----GLGPSMGGTQSSSSVPTGGSAGL-SG------- 77

  Fly   111 QLHQIRLGRSPG-SQFETRDV-LPQGLAS--PGSPTDVGKADGQCLRDGEIVVFDDIDTNWMNKA 171
              |.:|...:|| |.||..|: :..|:.|  |||...||.                      :.|
  Fly    78 --HHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGS----------------------SAA 118

  Fly   172 SSGQRPGSNEDVLK--------------VTKMIGQLPIAEY-----EGSPRRFGSQPNTNTITMG 217
            :.|.|.|::...|:              .:..|.:.|.:.:     .|.|.:.||.|...:..:.
  Fly   119 AGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLS 183

  Fly   218 GPRKRPPGFPQRVSPTTSVA-------NNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYL 275
            .            ||.:.:|       ..:|||:..|:|      .|........|..:|
  Fly   184 S------------SPASHMAAGTAGTLPTSTAASGRSMG------QHASSNGNKKRPISP----- 225

  Fly   276 YEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQPQEYPATPMEQAYIGQRLARIPKDEL 340
                  .:||..|                      .::|....|.:....:..|.|      |..
  Fly   226 ------EQVLRMF----------------------GATQSSSVPTSSYHYSNGGTR------DRD 256

  Fly   341 YMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTD 405
            ....|||...|     |||.:|.:.|.|...|   ||..::.:               |:..|.
  Fly   257 RTGRRSPASSP-----PSTTHQIYRDRERERD---RSVPNIHE---------------LTTRTV- 297

  Fly   406 YDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSG---HASDTENNVSVVCDKQQSSQSQPV 467
                     |:|.|......||      ..::.|..||   :.|..|.|  .|.::........:
  Fly   298 ---------SMSRDQQIDHGFG------ICVKGGKDSGLGVYISRIEEN--SVAERAGLRPGDTI 345

  Fly   468 HEHNG-------NGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIAD 525
            .|.||       :.|.|:....::.:|.....|..:...|.|   :.|:....|||..|..
  Fly   346 LEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNS---TAPLHGFGPPSRDPMY---- 403

  Fly   526 ASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKE 590
                .:|.|    ||.....|..|||       .:|.||.|         ||.:
  Fly   404 ----ASMAP----PLHPQNQAAAAAA-------AAAASGAG---------LPFR----------- 433

  Fly   591 IRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQ--GAAADEEPDTDLETDRLL-- 651
                           :.|.           |:.|.|...|...  |....|..|.....:.|:
  Fly   434 ---------------QTCS-----------WMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEP 472

  Fly   652 GQQ-----------------RHDEQDFFADQSLADNNANEGTDIASNGHLNGTS--DNNNPNPMN 697
            ||.                 ...::|..||:|    ....|.:|.   .:||.|  |..:...:.
  Fly   473 GQSLGLMIRGGVEYGLGIFVTGVDKDSVADRS----GLMIGDEIL---EVNGQSFLDVTHDEAVG 530

  Fly   698 NSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQF-TKSPTGSIKSLKDSANSD 761
            ..|.....:..||.                ||....|.:|.|...: ..||||:....|....:.
  Fly   531 QLKYHKRMSLVIRD----------------VGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATM 579

  Fly   762 KKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKST---------RMMQAEE---AVS 814
            .:.|:|:             :|.|..:...:..:.|......|         .|:...|   .|:
  Fly   580 VEEKARS-------------LLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVT 631

  Fly   815 RIKALA-PEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFV 878
            .|:.|. ||..    |..|..:...:....:.|......|.| |.:...||  ||.::.|..|
  Fly   632 EIRELVFPEDR----TRYDELVYRRERDPYSVDRHRRKGDPA-RDLPVTAD--DLEIIAATGR-- 687

  Fly   879 PNSVVDPSITSPLGDVPT-----PGI------------------------GEEE-----SPPKE- 908
                 .||..|.||...|     |.:                        |..:     |||::
  Fly   688 -----SPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQ 747

  Fly   909 --------------------------------PL---------SKHNRTPKMICH---------- 922
                                            ||         :|.|:..:..|.
  Fly   748 QQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSET 812

  Fly   923 ---VFESDEAQFIAQSIGQAFQVAYMEFLKANG---IENESLAKEMDYQEVLNSQEIFGDELEIF 981
               .:|.|..|.:|..:.::|.      :|..|   :.::.:.:....|. |::::..|...|
  Fly   813 LLPEYEPDAEQELATKLSRSFD------MKEEGGTLLGDKGVRRHQSMQR-LSAEQNGGSTTE-- 868

  Fly   982 AKKELQKEVVVPKAKGE----------ILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIG 1036
             :.......|||..:|.          |||:.| |.|..:..|...|.|:..:|||...|.|.:|
  Fly   869 -QTHEHNPNVVPDHRGNLHITVKKTKPILGIAI-EGGANTKHPLPRIINIHENGAAFEAGGLEVG 931

  Fly  1037 DQLIAINGMSLVGLPLSTCQSYIRNA-KNQTAVKFTVVPCPPVVEVK--ILRPK 1087
            ..::.::|..:.||........|... .|:...:.|.:    |||.|  .|.||
  Fly   932 QLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFL----VVEAKKSNLEPK 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	46/283 (16%)
		PDZ_signaling	988..1065	CDD:238492	23/87 (26%)
		PDZ_signaling	1092..1151	CDD:238492
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	20/103 (19%)
		PDZ_signaling	466..543	CDD:238492	14/83 (17%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	16/96 (17%)
		PDZ_signaling	886..971	CDD:238492	21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900