DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and GRID2IP

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	1192	Identity:	225/1192 - (18%)
Similarity:	375/1192 - (31%)	Gaps:	457/1192 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSPDLNGELSYVPLQGLSPSGGGVQG 90
            ::||..|..:..:.:::.||.:...|..:|...|     :.|         |.:..|...||:.|
Human   222 RRAQGAQRLRRSRSEERPERLLVSTRASAPPRRP-----DEP---------PPRRASLLVGGLAG 272

  Fly    91 SGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQGLAS--PGSPTDVGKADGQCLR 153
            .|.              .|..:...:..:|.|  |..|...|..:.|  ||||     ||...|:
Human   273 PGG--------------ARRTVRVYKGNKSFG--FTLRGHGPVWIESVLPGSP-----ADNAALK 316

  Fly   154 DGEIVVF-DDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITMG 217
            .|:.::| :.:|          .|..|::.|:.:.:..|.:|....|.....|.|  :::::...
Human   317 SGDRILFLNGLD----------MRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFAS--DSDSLDSP 369

  Fly   218 GPRKRPPGFPQRVSPTTS---VANNATAAAKASVGNLIDLVDH---EEERSGTLREKTPTFDY-- 274
            .|.          |..||   ||....::.:.........::|   ..||.|..|.....|.:
Human   370 NPS----------SALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRN 424

  Fly   275 -------LYEFSET--RKVLEEF-FKANPEDEKR-----------YTDYTTESGDDV-ASSQPQE 317
                   :|...:|  ::||.:| ::....:|:.           ||..|.|...:: ..|:|
Human   425 IDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEP-- 487

  Fly   318 YPATPMEQAYIGQRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGD-- 380
               ||..|.....|.:.:.:..|    ||...:......||    |..::.|.:....|.:||
Human   488 ---TPEPQPRSSLRASSMCRRSL----RSQGLEAGLSCGPS----ECPEMPLPLIPGERQAGDGT 541

  Fly   381 -LADT-----------ELEANLRRH------------------SRNFTLSPETTDYDSNCGDLDS 415
             |.:|           |||:.|...                  |...|..|.|.
Human   542 SLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTL----------- 595

  Fly   416 LSNDINCPTDFGKLYTS---MPVLEDGLSSGHASDTENNVSVVCDKQQSSQ-------------- 463
              :.::.|::  :|..|   .|:...||:|..:|::....|:...:..|.|
Human   596 --SGVSWPSE--RLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSP 656

  Fly   464 --------------SQPVHEHNGN----------GERL---------ENDYNVMS-----ASLAT 490
                          |.||...:.:          |.|:         ||||..||     .|..|
Human   657 DPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVT 721

  Fly   491 ---------LTTDASQSAL----ISDFASLPMPP-APPPSSPPQIEIADASESMTMVPDADNPLD 541
                     :::....|:|    |||  .:|.|| :|||  ||.:...||..|
Human   722 NERSSASDCISSSEEGSSLTYSSISD--HIPPPPLSPPP--PPPLPFHDAKPS------------ 770

  Fly   542 SHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLK 606
                            .:|:....|          |:||.:         :...|.:...|.
Human   771 ----------------SRSSDGSRG----------PAQALA---------KPLTQLSHPVPP--- 797

  Fly   607 FCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNN 671
                  |..|..|..||.....:|...|....|  .:.:...||..:|..:.:.....|...|::
Human   798 ------PPPPPLPPPVPCAPPMLSRGLGHRRSE--TSHMSVKRLRWEQVENSEGTIWGQLGEDSD 854

  Fly   672 ANEGTDIASNGHLN---GTSDNNNPNPMNN-----------SKPQTYST-----------ATIRQ 711
            .::.:|:.....|.   ||.....|.|...           |..:.|:|           |.:||
Human   855 YDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQ 919

  Fly   712 GIGTSLTP----------------------------------NSPD--ICQIVGTTDISISSPE- 739
             :..|:.|                                  :.||  :.|:       :|.||
Human   920 -VLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQM-------LSVPEY 976

  Fly   740 -----KLQF-------TKSPTGSIKSLKDSA----NSDKKAKSRNKEGLLEPKVLIEGVLFRARY 788
                 .|.|       |:...||::.|:.::    ||.|.||            ::|.||....|
Human   977 KTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAK------------ILEFVLAMGNY 1029

  Fly   789 LGSTQLVCEGQP--TKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTEKIMVLNT---DLK 848
            |.      :|||  .|:|..        :|..|         ||::   ||:.:...:|   .|.
Human  1030 LN------DGQPKTNKTTGF--------KINFL---------TELN---STKTVDGKSTFLHILA 1068

  Fly   849 EIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKH 913
            :.:..|....:.:..|: ..|.|.|:       |...::||.|.|:                  |
Human  1069 KSLSQHFPELLGFAQDL-PTVPLAAK-------VNQRALTSDLADL------------------H 1107

  Fly   914 NRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKA--------NGIENES---LAKEMDY--- 964
            ....::      .|..|.|:.|....|.:....||:.        :|::.|:   |.|.:.:
Human  1108 GTISEI------QDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGE 1166

  Fly   965 -QEVLNSQEIFGDELEIFAKKE 985
             .:...|:..||...|..:|.|
Human  1167 DSKATTSEAFFGIFAEFMSKFE 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	37/191 (19%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		9/56 (16%)
		PDZ_signaling	278..353	CDD:238492	21/91 (23%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		4/44 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		7/53 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		21/106 (20%)
		FH2	820..1188	CDD:280362	82/447 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900