DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment X11L and slc9a3r1a

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_997872.2	Gene:	slc9a3r1a / 327272	ZFINID:	ZDB-GENE-031006-7	Length:	384	Species:	Danio rerio

Alignment Length:	382	Identity:	77/382 - (20%)
Similarity:	141/382 - (36%)	Gaps:	122/382 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GPRKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHE-------EERSGTLREKTPTFDYL 275
            |.:.:|..|.:.|.|     ::..|||....|:.:.||:.|       ::....:|:.....:.:
Zfish    25 GEKNKPGQFIRHVEP-----DSPAAAAGLLAGDKLALVNGENVEDEKHQQVVSRIRDTVGKLELV 84

  Fly   276 YEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQPQE--------YPATPMEQAYIGQRL 332
            ...:||.::|   .|.|.:.:|   :|.|:.....|.|:|::        ..:||:.:.....|:
Zfish    85 VLNAETAELL---LKHNLKCQK---EYVTDGIPIPAGSEPEDEVKNGTSSRESTPVPETNGDMRI 143

  Fly   333 ARI------PKDEL---------------YMVHRSPTK----------KPPSDQN---PSTAYQE 363
            .|:      .|:||               :.:|...||          ..|::::   |.....:
Zfish   144 DRLSVSSKDSKNELRPRLCHIKKGATGYGFNLHTEKTKPGQYIRAVDEDSPAEKSGLRPQDKIVQ 208

  Fly   364 HNDIELYIDSNS------RSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINC 422
            .|.|.::...:|      ::.||  :|:|          ..:.||...:..:|..|
Zfish   209 VNGISVHTMQHSEVVAAIKAGGD--ETKL----------LVVDPEADAFFMSCEIL--------- 252

  Fly   423 PTD---FGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVM 484
            ||:   .|.|...:|..|        ::.:.|..||      .:.:|         ::|...:..
Zfish   253 PTEEHLTGPLPEPIPRRE--------AEEQVNGKVV------QEEKP---------KVEMSLSSS 294

  Fly   485 SASLATLTTDASQSALISDFASLPMP---PAPPPSSPPQIEI------ADASESMTM 532
            |.|..|.|:.|...|.....||.|.|   |||..::.||.::      |||..::.|
Zfish   295 STSSNTSTSAAPAPASAPAPASAPAPASAPAPAMAAAPQEKVKEKASSADAGLALNM 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
slc9a3r1a	NP_997872.2	PDZ_signaling	7..86	CDD:238492	13/65 (20%)
		PDZ_signaling	159..238	CDD:238492	12/90 (13%)
		EBP50_C	242..384	CDD:312529	32/142 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900