DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and baz

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	189/992 - (19%)
Similarity:	306/992 - (30%)	Gaps:	363/992 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 AEYEGSPRRFGSQPNTNTITMGGPRKRPPGFPQRVSPTT--SVANNATAAAKASVGNLIDLVDHE 258
            |:.||.|.  |....:.::|:   .||||      ||:|  .|..::...           |.|.
  Fly    29 AKQEGIPH--GQLHKSYSLTL---PKRPP------SPSTYSCVKPDSWVT-----------VTHL 71

  Fly   259 EERSGTLREKTPTFDYLYEFSETR-KVLEEFFKANPEDEKRYTDYTTESGDDVASSQPQEYPATP 322
            :.:||.|...    |.:.:.::.| ::|..|....|:..      ..:.|.|.||........:|
  Fly    72 QTQSGILDPD----DCVRDVADDREQILAHFDDPGPDPG------VPQGGGDGASGSSSVGTGSP 126

  Fly   323 MEQAYIGQRLARIPKDELYMVHRSP--TKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLA--- 382
                               .:.|.|  |:.|...::.||.         :|:..|.:||.:|
  Fly   127 -------------------DIFRDPTNTEAPTCPRDLSTP---------HIEVTSTTSGPMAGLG 163

  Fly   383 ---------DTELEANLRRHSRNFTLSPETTDYDSNCGD------LDSLSNDINCPTDFGKLYTS 432
                     |..|.|:|:....|...|.....|..  ||      ||.....::
  Fly   164 VGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAG--GDSPERLFLDKAGGQLS----------- 215

  Fly   433 MPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGE-----------RLE-------N 479
             |..|:.....|..           |:|....|..|..||...           ||.       |
  Fly   216 -PQWEEDDDPSHQL-----------KEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGN 268

  Fly   480 DYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEI------ADASESMTMVPDADN 538
            .|..|.|:      :..|:          .|||...........      |.:|:|:........
  Fly   269 GYKWMEAA------EKLQN----------QPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKE 317

  Fly   539 PLDSHYGAV-------------YAAALGGTH-TEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMK 589
            ||...|.::             |.:.||.|. .:|..|.||.|..|..|
  Fly   318 PLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPG---------------- 366

  Fly   590 EIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQ 654
                    ::.:..:|:..|.:|..:     .:...|.|.|..|.........::|....|.|.:
  Fly   367 --------SRAERGRLRRDDRILEIN-----GIKLIGLTESQVQEQLRRALESSELRVRVLRGDR 418

  Fly   655 RHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTP 719
            ...:|        .|:...|..::|:      .|....|    ::.|           :||||
  Fly   419 NRRQQ--------RDSKVAEMVEVAT------VSPTRKP----HAAP-----------VGTSL-- 452

  Fly   720 NSPDICQIVGTTDIS-------ISSPEKLQFT----KSPTGS-----IKSL--KDSANSDKKAKS 766
                  |:..|..:.       ...|..|.|:    .:|.|.     ||::  :.:|..|.:.|.
  Fly   453 ------QVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKP 511

  Fly   767 RNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEV 831
            .::  |||    ::|.....:.......:..|.|..:|    ....|||.:.||.:.: ||:
  Fly   512 GDR--LLE----VDGTPMTGKTQTDVVAILRGMPAGAT----VRIVVSRQQELAEQAD-QPA--- 562

  Fly   832 DLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPT 896
                  ||                      .|.:.           |..||..|::  |....|.
  Fly   563 ------EK----------------------SAGVA-----------VAPSVAPPAV--PAAAAPA 586

  Fly   897 PGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKE 961
            |.|..::|.....|..|.:..::       :|:|               .|:.|.   :||.|..
  Fly   587 PPIPVQKSSSARSLFTHQQQSQL-------NESQ---------------HFIDAG---SESAASN 626

  Fly   962 MDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVI--------------VESGWGSM 1012
            .......||..         :::||...:.|...:...|||.:              ..||...:
  Fly   627 DSLPPSSNSWH---------SREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGL 682

  Fly  1013 LP-----TVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTV 1072
            :.     .:.:.|::..|||:|.|:|.:.|||:::||:||.|...:.....:|.|...|..|.
  Fly   683 MKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKH-- 745

  Fly  1073 VPCPPVVEV----KILR 1085
               |..:.:    ||||
  Fly   746 ---PGTITLLVGRKILR 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	29/178 (16%)
		PDZ_signaling	988..1065	CDD:238492	23/95 (24%)
		PDZ_signaling	1092..1151	CDD:238492
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	26/160 (16%)
		PDZ_signaling	341..412	CDD:238492	18/99 (18%)
		CRS1_YhbY	<390..>436	CDD:294440	10/53 (19%)
		PDZ_signaling	462..548	CDD:238492	17/95 (18%)
		PDZ_signaling	<686..753	CDD:238492	20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900