DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and APBA2

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001340717.1	Gene:	APBA2 / 321	HGNCID:	579	Length:	749	Species:	Homo sapiens

Alignment Length:	904	Identity:	332/904 - (36%)
Similarity:	435/904 - (48%)	Gaps:	247/904 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 HRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDS 408
            ||......|..|.|     |..|:||.::.......:||....|:.          :||..:..:
Human    16 HRVRPGPVPHSQEP-----ESEDMELPLEGYVPEGLELAALRPESP----------APEEQECHN 65

  Fly   409 NCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLS--------------------------SGHASD 447
            :..|.||.|:.:|..::.......:|..|:|::                          |.|..|
Human    66 HSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSAHPVD 130

  Fly   448 TENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPA 512
            |:.....|.:...|:...| |.|...|.:   ||                     ....||:
Human   131 TDECQEAVEEWTDSAGPHP-HGHEAEGSQ---DY---------------------PDGQLPI--- 167

  Fly   513 PPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGG--THTEKSAGSGLGVTPV---TA 572
             |...|..:|..|..|            |.|    |.|:..|  .:..:.|....|.:|.   ..
Human   168 -PEDEPSVLEAHDQEE------------DGH----YCASKEGYQDYYPEEANGNTGASPYRLRRG 215

  Fly   573 GGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAA 637
            .|.|..| ..:|.:.:.||:.:|..                             |:|::|..|:.
Human   216 DGDLEDQ-EEDIDQIVAEIKMSLSM-----------------------------TSITSASEASP 250

  Fly   638 DEEPDTDLETD-----------------------RLLGQQRH--DEQDFFADQSLADN------- 670
            :..|:...|..                       .||.:.:|  |.|..|..::....
Human   251 EHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPH 315

  Fly   671 ----NANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTT 731
                |..|.........|||..||||       .|:|...|
Human   316 EQVCNGLEQPRKQQRSDLNGPVDNNN-------IPETKKVA------------------------ 349

  Fly   732 DISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVC 796
                |.|   .|...|                       |..||:.||:|::|.|.|||||||:.
Human   350 ----SFP---SFVAVP-----------------------GPCEPEDLIDGIIFAANYLGSTQLLS 384

  Fly   797 EGQPTKSTRMMQAEEAVSRIKALA----------PEGESQPSTEVDLFISTEKIMVLNTDLKEIM 851
            |..|:|:.|||||:|||||:|.:.          .||::|..|||||||||::|.|||.|.:|.|
Human   385 ERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETM 449

  Fly   852 MDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRT 916
            |||||||||||||||::|||||||| :|.|.....|.:      |||..|.:           :.
Human   450 MDHALRTISYIADIGNIVVLMARRR-MPRSASQDCIET------TPGAQEGK-----------KQ 496

  Fly   917 PKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIF 981
            .|||||||||::||.|||||||||.|||.|||:||||..|.|::: :|.:::|:||::.|:|..|
Human   497 YKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQK-EYSDIINTQEMYNDDLIHF 560

  Fly   982 AKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMS 1046
            :..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:||||:::|||.|
Human   561 SNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTS 625

  Fly  1047 LVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAE 1111
            ||||||:|||..|:..||||.||..:|.||||..|.|.||...:|||||||||:||||:||||||
Human   626 LVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAE 690

  Fly  1112 RGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            ||||||||||||||.|||||..|:.||:.||:|||||.|||||.:|||||||||||:||
Human   691 RGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	105/188 (56%)
		PDZ_signaling	988..1065	CDD:238492	50/76 (66%)
		PDZ_signaling	1092..1151	CDD:238492	47/58 (81%)
APBA2	NP_001340717.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		20/92 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..220		26/134 (19%)
		STXBP1-binding	185..270		20/118 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..344		21/141 (15%)
		PTB_X11	363..535	CDD:269919	106/189 (56%)
		PDZ	568..651	CDD:395476	54/82 (66%)
		PDZ_signaling	657..730	CDD:238492	53/72 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3726
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8492
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.800