DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment X11L and APBA1

DIOPT Version :9

Sequence 1:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001154.2	Gene:	APBA1 / 320	HGNCID:	578	Length:	837	Species:	Homo sapiens

Alignment Length:	1013	Identity:	358/1013 - (35%)
Similarity:	474/1013 - (46%)	Gaps:	275/1013 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RKRPP------GFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEF 278
            :::||      |..||        ..|....:|.:|      ..||||...|.....|....:..
Human    38 QQQPPQQQHYVGRHQR--------GRALEDLRAQLG------QEEEERGECLARSASTESGFHNH 88

  Fly   279 SETRK-----VLEEFFKA----NPEDEKRY-TDYTTESGDDVASSQPQEYPAT------------ 321
            ::|.:     ...:.:.|    :||||..| ..|..|:.:....::.:...||
Human    89 TDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFH 153

  Fly   322 ------PMEQAYIG----QRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSR 376
                  .|..||.|    .||....:||       |..:|.:|..   ..|||...|:
Human   154 SLEHEEAMNAAYSGYVYTHRLFHRGEDE-------PYSEPYADYG---GLQEHVYEEI------- 201

  Fly   377 SSGDLADTELEANLRRHS---------RNFTLSPETTDYDSNC-GDLDSLSNDINCPTDFGKLYT 431
              ||..:.:....||.:.         |...|......||... |:.||...:    .:|.. |.
Human   202 --GDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDERSDGESDSPEKE----AEFAP-YP 259

  Fly   432 SMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDAS 496
            .|...|         ..|:...:|.:.:||..||.:.:...:....|.|
Human   260 RMDSYE---------QEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQD---------------- 299

  Fly   497 QSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSA 561
                      |..||.|....|                  |:|                ..:..|
Human   300 ----------LERPPTPAGGRP------------------DSP----------------GLQAPA 320

  Fly   562 GSGLGVTPVTAGGSLPSQAASE-----IQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVW 621
            |....|.|  |||....|..|:     |..|:|:|:.|::..||:..:..:    .|.:|..|:|
Human   321 GQQRAVGP--AGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPY----TPDEPKEPIW 379

  Fly   622 VPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNG 686
            |.|:            |..|..|.:..|.:
Human   380 VMRQ------------DISPTRDCDDQRPM----------------------------------- 397

  Fly   687 TSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSI 751
              |.::|:|.::|.....|::       |||.|:.|        .:.|.:...:......||
Human   398 --DGDSPSPGSSSPLGAESSS-------TSLHPSDP--------VEASTNKESRKSLASFPT--- 442

  Fly   752 KSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRI 816
                          .....|..:|:.||:|::|.|.|||||||:.:..|:|:.|||||:||||||
Human   443 --------------YVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRI 493

  Fly   817 KAL---------APEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLM 872
            |..         ||||||||.|||||||||::|.|||.|.:|.||||.|||||||||||::||||
Human   494 KMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLM 558

  Fly   873 ARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIG 937
            |||| :|.|                 ..:|......|.....|..|||||||||::||.||||||
Human   559 ARRR-MPRS-----------------NSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIG 605

  Fly   938 QAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGV 1002
            |||.|||.|||:||||..|.|::: :|.::||:|:::.|:|..|:|.|..|:|.:.|.|||||||
Human   606 QAFSVAYQEFLRANGINPEDLSQK-EYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGV 669

  Fly  1003 VIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTA 1067
            |||||||||:||||:|||:|..|.|.:.|:||||||:::|||.||||||||||||.|:..|||:.
Human   670 VIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSR 734

  Fly  1068 VKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAV 1132
            ||..:|.||||..|.|.||...:|||||||||:||||:||||||||||||||||||||.|||||.
Human   735 VKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVAT 799

  Fly  1133 PHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            ||:.||.:||::||||.|||||.:|:||||.||.|:||
Human   800 PHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	107/187 (57%)
		PDZ_signaling	988..1065	CDD:238492	53/76 (70%)
		PDZ_signaling	1092..1151	CDD:238492	47/58 (81%)
APBA1	NP_001154.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		15/68 (22%)
		Munc-18-1 binding	226..314		25/145 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..342		33/179 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..435		23/144 (16%)
		LIN-2/CASK binding	373..436		20/126 (16%)
		PTB_X11	452..623	CDD:269919	108/188 (57%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	626..641		5/15 (33%)
		PDZ	656..739	CDD:278991	56/82 (68%)
		PDZ_signaling	745..818	CDD:238492	53/72 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3726
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8492
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	1	1.000	-	-		X1305
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750